Leishmaniasis

This study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…

This study tests whether using a device that heats skin lesions to 50°C for 30 seconds can effectively treat cutaneous leishmaniasis in primary health centers in Ethiopia. 103 patients aged 12 to 60 with up to four lesions will receive thermotherapy and be monitored for 90 days. …

This phase 3 trial tests whether a plant-based tincture made from arnica flowers can safely and effectively heal skin ulcers caused by cutaneous leishmaniasis, a parasitic disease spread by sandflies. About 96 people aged 12 and older with confirmed infection will receive either …

This study tests whether injecting the antibiotic ciprofloxacin directly into skin sores caused by leishmaniasis works as well as the standard treatment, sodium stibogluconate. Eighty people with one to seven sores will be randomly assigned to receive weekly injections of one dru…

This study tests whether injecting the antibiotic levofloxacin directly into skin sores caused by leishmaniasis can cure them. Forty adults with up to seven sores will receive weekly injections for up to six weeks and be monitored for 90 days. The goal is to see if the sores heal…

This study aims to see if a new PCR-based test can diagnose malaria, leishmania, and pneumocystis infections faster and more accurately than current methods. Researchers will analyze about 200 stored samples from patients. The goal is to improve diagnosis and species identificati…

This study looks at how leishmaniasis infections progress and respond to treatment. It involves up to 289 people aged 3 to 100 with known or suspected leishmaniasis. Researchers will collect blood and tissue samples to learn more about the disease and test different treatments. T…

This study tracks 200 children in Italy with leishmaniasis, a parasitic infection that can affect the skin or internal organs. Researchers will look at how quickly the disease is diagnosed and treated, and how that affects recovery, relapse, and death rates. The goal is to identi…

This study looks at 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to find out why the parasite keeps coming back in some patients and how to better monitor treatment. Participants provide samples and attend foll…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…