Gram-positive bacterial infections

This early-stage study is testing a new vaccine called V118E to see if it is safe and well-tolerated in healthy adults. The vaccine aims to protect against infections caused by Streptococcus pneumoniae bacteria, which can cause pneumonia and other serious illnesses. Around 126 he…

This study tests a new pneumococcal vaccine (PG4) in healthy children aged 15 months to 18 years. About 1,200 participants will receive either the new vaccine or the current Prevnar 20. Researchers will compare safety and immune response over 6 months. The goal is to see if the n…

This study tests a vaccine given to pregnant women to see if it can protect their babies from group B streptococcus (GBS) infection, a serious illness in newborns. Healthy pregnant women aged 49 or younger, between 24 and 36 weeks of pregnancy, can join. Participants receive one …

This early-stage trial tests a new vaccine called VAX-A1 in 80 healthy adults aged 18-40. The vaccine aims to prevent infections caused by Group A Streptococcus bacteria, which can cause strep throat and more serious illnesses. The study focuses on safety and immune response, wit…

This study tests a new pneumococcal vaccine in healthy infants to see if it is safe and works better than the current vaccine. About 3,230 babies will receive either the new vaccine or the existing one at routine checkups. Researchers will compare side effects and immune response…

This study tests a new pneumococcal vaccine in about 2400 healthy infants starting at 2 months old. The goal is to see if the new vaccine is as safe as the current vaccine, Prevnar 20, and if it can protect against more types of bacteria that cause pneumonia, meningitis, and ear …

This study tests whether two different pneumococcal vaccines can create antibodies that kill newly discovered types of pneumonia bacteria. Researchers will give healthy adults one of the vaccines and measure how well their immune system fights these bacteria. The goal is to see i…

This early-stage trial is testing a new vaccine called V118C to prevent pneumococcal disease, which can cause serious lung and other infections. About 210 toddlers and infants will receive either V118C or an existing vaccine to compare safety and immune response. The study is cur…

This study tests a new 21-valent pneumococcal vaccine (PCV21) in 100 children and teens with sickle cell disease, aged 2 to 17. The goal is to see if it's safe and helps the body make antibodies better than the current 20-valent vaccine. Participants get one shot and are monitore…

This study tests whether a two-shot pneumonia vaccine series (PCV20 and PPSV23) can help people with chronic lymphocytic leukemia (CLL) build a stronger immune defense against pneumococcal infections. About 61 adults with CLL who have not yet had treatment, or who are on a specif…

This study looks at whether giving the 20-valent pneumococcal vaccine (PCV-20) to adults while they have a fever is as effective and safe as waiting until they are well. About 1052 adults with certain health risks (like heart or lung disease) will take part. The goal is to see if…

This study is checking how safe the Prevenar 20 vaccine is once it's used in Korea. About 660 people aged 6 weeks and older who are prescribed the vaccine will get one dose. Researchers will track any side effects for 28 days after vaccination.

This study tests a new vaccine to protect babies against pneumococcal infections, which can cause pneumonia and meningitis. About 600 healthy infants in Thailand will receive either the new or a standard vaccine at 2, 4, and 12-15 months old. Researchers will check how well the v…

This Phase 3 trial is testing a new 13-valent pneumococcal conjugate vaccine (PCV13) in over 3,000 healthy infants and children aged 6 weeks to 5 years. The goal is to see if the vaccine is safe and triggers a strong immune response compared to an existing vaccine. If it works, i…

This study tests a new vaccine (PCV24) designed to protect children aged 2 to 23 months against 24 types of pneumococcal bacteria, which can cause serious infections like pneumonia and meningitis. Around 180 healthy children will receive either the new vaccine or an existing one …

This study tests a new vaccine (RZ700) designed to protect infants and young children against 24 types of pneumococcal bacteria, which can cause pneumonia, meningitis, and ear infections. About 480 healthy children aged 6 weeks to 71 months will receive the vaccine to see if it t…

This early-stage trial is testing a new vaccine that combines protection against several serious childhood diseases: diphtheria, tetanus, whooping cough, meningitis, and Hib. The study involves 260 children aged 2 months to 6 years to check the vaccine's safety and immune respons…

This study tests a new vaccine called PCV24 in 420 healthy children aged 2 months to 5 years. The vaccine targets 24 types of pneumococcal bacteria, which can cause pneumonia, meningitis, and ear infections. Researchers will compare it to an existing vaccine to see if it is safe …

This early-stage study will give 12 healthy adults a killed whole-cell pneumococcal vaccine called Gamma-PN. The main goal is to collect blood samples to help develop and validate lab tests that measure immune responses. The study does not aim to prove the vaccine works in people…

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug tw…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This study tests whether fecal microbiota transplantation (FMT) capsules, made from healthy donor stool, can prevent C. diff infection from coming back better than standard antibiotics. About 100 adults with a first or first-recurrent C. diff infection will get either antibiotics…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This study compares two pneumococcal vaccination strategies in 160 adults with lymphoma who have had chemotherapy. One group gets two vaccines (Prevenar 13 followed by Pneumovax 23), while the other gets a single newer vaccine (Prevenar 20). Researchers will measure immune respon…

This study tests whether taking capsules made from healthy donor stool (fecal microbiota transplantation, or FMT) can prevent another bout of C. diff infection in people who have had it come back at least twice. 76 adults will receive either active FMT capsules or placebo, and re…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study provides a fecal transplant product made from healthy donor stool to treat people with recurrent Clostridium difficile infection or multidrug-resistant urinary tract infections. The product is delivered by courier or FedEx after a contract is signed. The goal is to res…

This study is testing whether transplanting stool from a healthy donor into the colon can prevent recurrent C. diff infections. The procedure, done via colonoscopy, aims to restore good bacteria that keep C. diff in check. Researchers are tracking 500 people to see if this stops …

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This pilot study is testing whether giving activated charcoal within 6 hours of swallowing a poisonous substance can prevent the poison from getting worse and shorten hospital stays. About 100 adults and children who have ingested a substance that charcoal can absorb will be rand…

This study looks at whether the antibiotic clindamycin works as well as other drugs for treating Streptococcus infections in artificial joints. Researchers will compare success rates in 260 adults who had surgery for this infection. The goal is to see if clindamycin can be a good…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

People without a working spleen are at high risk of severe infections from pneumococcus bacteria. This study looks at how well the pneumococcal vaccine works in adults aged 18-65 who have a spleen injury and are treated with monitoring, embolization, or spleen removal. Researcher…

This study tests a new device that uses artificial intelligence to help diagnose ear infections, strep throat, and asthma flare-ups in children. About 84 kids aged 3 to 17 will either use the device at home with a doctor's video visit or receive standard in-person care. The goal …

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests whether a specific diet can change gut bacteria and help prevent another C. difficile infection in adults who have had one. Twenty participants will receive prepared meals and health counseling, then follow a similar diet for 6 more weeks. Researchers will track …

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause pneumonia and other serious infections. About 2,200 healthy infants will receive four doses of either the new vaccine or an existing one starting at 2 mont…

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This study tests an experimental drug called LMN-201 to see if it can prevent C. difficile infection from coming back after standard antibiotic treatment. About 375 adults with a recent C. diff infection will receive either LMN-201 or a placebo. The main goal is to see if more pe…

This large real-world study is testing an injection called siltartoxatug (Sintetol®) to prevent tetanus in people who have been injured. Researchers will follow 10,000 participants for 90 days to see if the shot prevents tetanus and to track any side effects. The goal is to learn…

This study tests whether giving a daily dose of oral vancomycin can prevent Clostridioides difficile (C. diff) infection in critically ill adults who are already on other antibiotics in the hospital. About 176 high-risk patients will receive either vancomycin or a placebo while t…

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study tests whether a rapid lab test can help doctors choose the right antibiotic sooner for patients with bloodstream infections. About 400 adults with positive blood cultures will be randomly assigned to either the rapid test or standard testing. The goal is to see if the …

This study looks at bile acid profiles in children with ulcerative colitis (UC) who also have a C. difficile infection. Researchers want to see if changes in bile acids and gut bacteria make these children more vulnerable. They will compare three groups: children with UC flare-up…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study follows 60 adults who have had a C. diff infection return after standard antibiotic treatment. Researchers want to see how often the infection comes back within 8 weeks and whether measuring toxin levels in stool can predict that risk. Participants provide stool sample…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at whether charcoal-filtered cigarettes change how people smoke and how much harmful chemicals they breathe in. About 252 adult smokers who smoke at least 5 cigarettes a day will be randomly assigned to smoke either charcoal-filtered or regular cigarettes for 4 w…

This study follows people who have or had anthrax, those exposed, and healthy vaccinated volunteers to learn how the body fights the disease. Researchers will track symptoms, immune responses, and long-term health for up to 2 years. The goal is to better understand anthrax and im…

This study looks at three different scoring systems to see which one best predicts the risk of death in patients with severe tetanus in the intensive care unit. Researchers will follow 115 adults with tetanus for up to 90 days. The goal is to find the most accurate tool to help d…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study prepares medical sites in Kenya, Malawi, Mozambique, and Uganda for future trials of a vaccine against Group B Streptococcus (GBS), a leading cause of serious infections in newborns. Researchers will track pregnancy and infant health data and monitor GBS cases in babie…

This study tests whether a web-based educational program can improve pregnant women's knowledge about influenza and Tdap vaccines and increase their intention to get vaccinated. Researchers will compare the program to standard antenatal care in 351 pregnant women in Malaysia. Par…

This study collects blood from 50 women in Uganda who previously received an experimental group B strep (GBS) vaccine during pregnancy. The blood is used to create quality control panels that help labs accurately measure vaccine-induced antibodies. The goal is to improve testing …

This study is observing 2,500 children in France to understand how pneumococcal vaccines have changed the severity and types of pneumococcal infections. Researchers will look at which bacterial strains cause disease, how severe the infections are, and whether children were vaccin…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at how a type of immune cell called neutrophils affects the body's response to the pneumococcal vaccine in young (21-40) and older (65+) adults. Researchers will measure how well neutrophils kill pneumonia bacteria after vaccination. The goal is to understand why…

This early-stage study is testing whether a single dose of an experimental antibiotic combination (sulopenem etzadroxil plus probenecid) is safe and tolerable in 12 adolescents already receiving standard antibiotics for a bacterial infection. Researchers will measure how the drug…

This study tracks how fecal microbiota transplantation (FMT) alters the gut microbiome in 20 adults with recurrent Clostridioides difficile infection. Researchers will analyze stool samples before and up to 90 days after FMT to see which bacteria take hold. The goal is to underst…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study follows 100 hospitalized patients with Clostridioides difficile infection to track how quickly the bacteria clears from the gut during and after standard antibiotic treatment. Researchers will also analyze gut bacteria and immune responses in stool samples to identify …

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study looks at children ages 5 to 15 who test positive for strep throat to understand why some become carriers—meaning they have the bacteria but no symptoms. Researchers will collect throat samples and analyze gene activity to compare carriers with those who have active inf…

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study watches 200 adults with C. diff infection to see how standard antibiotics and fecal microbiota transplantation (FMT) help people recover. Researchers will collect stool, blood, and urine samples over up to 5 years to understand why some treatments succeed and others fa…

This study is a national registry that will follow up to 4,000 people who receive a fecal microbiota transplant (FMT) for C. diff infection or other gut conditions. Researchers will track side effects, infections, and whether the disease comes back. The goal is to better understa…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study is looking back at medical records of 400 adults hospitalized with a serious strep blood infection (Streptococcus anginosus group). The goal is to find out which factors are linked to a higher chance of dying within 28 days. By understanding these risk factors, doctors…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…