One-Shot flu prevention? new drug aims to protect High-Risk groups all season

NCT ID NCT07159763

Ongoing Prevention Sponsor: Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether a single dose of CD388, a long-acting antiviral injection, can prevent the flu in 10,000 adults and teens at higher risk of complications. Participants receive either CD388 or a placebo and are monitored for flu-like illness over 24 weeks. The study is fully enrolled but not yet reporting results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

CD388 (a long-acting antiviral injection)

What this could lead to

If successful, this could provide a new way to prevent influenza with a single dose, especially for people at higher risk of complications.

What could go wrong

This is a large phase 3 trial, but results are not yet available. The drug may not prove effective or could have side effects not seen in earlier studies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA

Contacts and locations

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Locations

AIM Research

Merewether, New South Wales, 2291, Australia
AMR Clinical

Newton, Kansas, 67114, United States
Aberdeen Royal Infirmary

Aberdeen, Scotland, AB25 2ZD, United Kingdom
Acclaim Clinical Research

San Diego, California, 92120, United States
Agile Clinical Research Trials, LLC

Atlanta, Georgia, 30328, United States
Altoona Center for Clinical Research

Duncansville, Pennsylvania, 16635, United States
Annapolis Internal Medicine / Avacare

Annapolis, Maryland, 21401, United States
Arizona Clinical Trials

Tucson, Arizona, 85711, United States
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Australian Clinical Research Network Pty Ltd

Maroubra, New South Wales, 2035, Australia
Brooklyn Clinical Research

Brooklyn, New York, 11226, United States
CAPRISA eThekwini Clinical Research Site

Durban, 4001, South Africa
CEMER Centro Médico Enfermedades Respiratorias

Buenos Aires, B1602DQD, Argentina
CHEAR Center, LLC

The Bronx, New York, 10455, United States
CINME - Centro de Investigaciones Metabolicas

Buenos Aires, C1027AAP, Argentina
Cardiff and Vale UHB - University Hospital of Wales

Cardiff, Wales, CF14 4XW, United Kingdom
Central Erie Primary Care

Erie, Pennsylvania, 16508, United States
Centricity Research Columbus Ohio Multispecialty

Columbus, Ohio, 43213, United States
Centro de Estudios Infectológicos

Buenos Aires, C1002ABJ, Argentina
Charlottesville Medical Research Center, LLC

Charlottesville, Virginia, 22911, United States
Clay Platte Family Medicine, PC / Avacare

Kansas City, Missouri, 64151, United States
Clinical Neuroscience Solutions, Inc.

Orlando, Florida, 32806, United States
Clinical Research Atlanta

Stockbridge, Georgia, 30281, United States
Clinical Research Partners, LLC

Richmond, Virginia, 23226, United States
Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, 32789, United States
Clinical Trials of Texas, LLC dba Flourish Research

San Antonio, Texas, 78229, United States
Columbus Clinical Services, LLC

Miami, Florida, 33125, United States
Cope Family Medicine / Avacare

Bountiful, Utah, 84010, United States
Core Research Group Pty Ltd

Milton, Queensland, 4064, Australia
Critical Care, Pulmonary and Sleep Associates PLLP / Avacare

Lakewood, Colorado, 80228, United States
Cullman Clinical Trials

Cullman, Alabama, 35055, United States
DCT-HCWC, LLC dba Discovery Clinical Trials

Dallas, Texas, 75230, United States
DM Clinical Research

Philadelphia, Pennsylvania, 19107, United States
DM Clinical Research

Tomball, Texas, 77375, United States
Del Sol Research Management, LLC

Tucson, Arizona, 85715, United States
DelRicht Research

Atlanta, Georgia, 30329, United States
DelRicht Research

Louisville, Kentucky, 40205, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DelRicht Research

Prairieville, Louisiana, 70769, United States
DelRicht Research

Gulfport, Mississippi, 39503, United States
DelRicht Research

Springfield, Missouri, 65807, United States
DelRicht Research

Charlotte, North Carolina, 28205, United States
DelRicht Research

Tulsa, Oklahoma, 74133, United States
DelRicht Research

Charleston, South Carolina, 29407, United States
DelRicht Research

Hendersonville, Tennessee, 37075, United States
Desert Clinical Research, LLC / Avacare

Mesa, Arizona, 85213, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
Drug Trials America

Hartsdale, New York, 10530, United States
Elevate Clinical Research

Lake Charles, Louisiana, 70605, United States
Elevate Clinical Research

McAllen, Texas, 78504, United States
Elevate Clinical Research

Seabrook, Texas, 77586, United States
Emeritus Research Camberwell

Camberwell, Victoria, 3124, Australia
Emeritus Research Sydney

Botany, New South Wales, 2019, Australia
Emerson Clinical Research Institute

Washington D.C., District of Columbia, 20009, United States
Emmed Research

Pretoria, 0002, South Africa
Epic Clinical Research

Lewisville, Texas, 75057, United States
Equipo Ciencia

Buenos Aires, C1428BNF, Argentina
Excel Clinical Research

Las Vegas, Nevada, 89109, United States
Eximia EquiHealth Research, LLC

Durham, North Carolina, 27704, United States
Eximia Research-CA, LLC

La Mesa, California, 91942, United States
Eynsham Medical Centre

Eynsham, England, OX29 4QB, United Kingdom
Fiel Family and Sports Medicine / Avacare

Tempe, Arizona, 85283, United States
Finger Lakes Medical Research, PLLC dba Certified Research Associates

Cortland, New York, 13045, United States
Floridian Clinical Research, LLC

Miami Lakes, Florida, 33016, United States
Flourish Research - Miami, LLC DBA Flourish Research

Miami, Florida, 33135, United States
Foothills Research Center / Avacare

Phoenix, Arizona, 85044, United States
Fylde Coast Clinical Research at Layton Medical Centre

Blackpool, England, FY3 7EN, United Kingdom
Global Clinical Professionals

St. Petersburg, Florida, 33705, United States
Global Clinical Trials (Pty) Ltd

Pretoria, 0157, South Africa
Great Lakes Clinical Trials, LLC dba Flourish Research

Chicago, Illinois, 60640, United States
HMC Health, The Meadows Centre for Health, The Great West Surgery

Hounslow, England, TW4 7NR, United Kingdom
HOPE Research Institute

Glendale, Arizona, 85308, United States
HOPE Research Institute

Tempe, Arizona, 85284, United States
Hatboro Medical Associates / Avacare

Horsham, Pennsylvania, 19044, United States
Health Awareness, Inc.

Jupiter, Florida, 33458, United States
Health Awareness, Inc.

Port Saint Lucie, Florida, 34952, United States
Healthcare Clinical Data, Inc.

North Miami, Florida, 33161, United States
Henderson Clinical Trials

Henderson, Nevada, 89052, United States
Hillcrest Medical Research, LLC

DeLand, Florida, 32720, United States
IMA Clinical Research

Warren Township, New Jersey, 07059, United States
Imagine Research - Palm Beach County

Boynton Beach, Florida, 33435, United States
Innovative Research of West Florida, Inc.

Clearwater, Florida, 33756, United States
Instituto IBAMEDICA

Santa Fe, S3000ASF, Argentina
Integrated Clinical Trial Services, LLC

West Des Moines, Iowa, 50265, United States
Isango Lethemba TB Research Unit

Port Elizabeth, 6003, South Africa
Jadestone Clinical Research, LLC

Silver Spring, Maryland, 20904, United States
Javara, Inc.

Mankato, Minnesota, 56001, United States
Javara, Inc.

Stephenville, Texas, 76401, United States
Johnson County Clin-Trials, LLC

Lenexa, Kansas, 66219, United States
Jongaie Research

Pretoria, 0183, South Africa
Josha Research

Bloemfontein, Free State, 9300, South Africa
Kinetic Clinical Research, LLC dba Long Beach Clinical Trials

Long Beach, California, 90806, United States
Laguna Clinical Research Associates, LLC

Laredo, Texas, 78041, United States
Las Vegas Clinical Trials, LLC

North Las Vegas, Nevada, 89030, United States
Leeds Teaching Hospitals NHS Trust - St. James's University Hospital

Leeds, England, LS9 7TF, United Kingdom
Lonestar Clinical Research, LLC

Dallas, Texas, 75243, United States
Lynn Health Science Institute East

Oklahoma City, Oklahoma, 73111, United States
Madibeng Centre for Research

Brits, North West, 0250, South Africa
Methodist Physicians Clinic / Avacare

Fremont, Nebraska, 68025, United States
Midwest Regional Health Services, LLC / Avacare

Omaha, Nebraska, 68144, United States
Momentum Clinical Research St Leonards

Saint Leonards, New South Wales, 2065, Australia
Momentum Clinical Research Taringa

Taringa, Queensland, 4062, Australia
Monroe Biomedical Research

Monroe, North Carolina, 28112, United States
Montana Medical Research, Inc.

Missoula, Montana, 59808, United States
NHS Lothian - Western General Hospital

Edinburgh, Scotland, EH4 2XU, United Kingdom
National Institute of Clinical Research, Inc.

Garden Grove, California, 92844, United States
New England Research Associates

Bridgeport, Connecticut, 06606, United States
Newtown Clinical Research Centre

Johannesburg, 2001, South Africa
North Manchester General Hospital

Manchester, England, M8 5RB, United Kingdom
Olympus Family Medicine / Avacare

Salt Lake City, Utah, 84117, United States
OnSite Clinical Solutions, LLC

Salisbury, North Carolina, 28144, United States
Paarl Research Centre

Cape Town, 7646, South Africa
Panthera Enfield

London, England, EN3 4GS, United Kingdom
Panthera Preston

Preston, England, PR2 9QB, United Kingdom
Panthera Rochdale

Rochdale, England, OL11 4AU, United Kingdom
Panthera Sheffield

Sheffield, England, S2 5FX, United Kingdom
Panthera York

York, England, YO24 4LJ, United Kingdom
Paradigm Clinical Research

Redding, California, 96001, United States
Paradigm Clinical Research

Boise, Idaho, 83709, United States
Pearland Physicians

Pearland, Texas, 77581, United States
Pinnacle Research Group, LLC

Anniston, Alabama, 36207, United States
PriMed Clinical Research

Dayton, Ohio, 45429, United States
Profound Research, LLC

Pasadena, California, 91105, United States
Profound Research, LLC

Clarkston, Michigan, 48346, United States
Profound Research, LLC

Dearborn, Michigan, 48126, United States
Profound Research, LLC

Farmington Hills, Michigan, 48334, United States
Progressive Medical Research

Port Orange, Florida, 32127, United States
Qhakaza Mbokodo Research Clinic

Ladysmith, KwaZulu-Natal, 3370, South Africa
Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust

Birmingham, England, B15 2TH, United Kingdom
Queen Elizabeth University Hospital, Glasgow Clinical Research Facility

Glasgow, Scotland, G51 4TF, United Kingdom
Rainier Clinical Research Center

Renton, Washington, 98057, United States
Research Your Health

Plano, Texas, 75093, United States
Rochester Clinical Research

Rochester, New York, 14609, United States
Royal Cornwall Hospitals NHS Trust

Truro, England, TR1 3LJ, United Kingdom
Salford Royal Hospital

Salford, England, M6 8HD, United Kingdom
Sanatorio Mayo Privado S.A.

Córdoba, X5000FAL, Argentina
Santa Rosa Medical Centers of Nevada / Avacare

Las Vegas, Nevada, 89119, United States
Seaside Medical Group

Oceanside, California, 92058, United States
Skylight Health Research

Burlington, Massachusetts, 01803, United States
South Florida Research Center, Inc.

Miami, Florida, 33135, United States
Southmead Hospital, North Bristol NHS Trust - Clinical Research Centre

Bristol, England, BS10 5NB, United Kingdom
Spartanburg Medical Research

Spartanburg, South Carolina, 29303, United States
Stamford Therapeutics Consortium

Stamford, Connecticut, 06905, United States
Sundance Clinical Research, LLC

St Louis, Missouri, 63141, United States
Synergy Biomed Research Institute

East London, 5201, South Africa
TASK Applied Science, Central

Cape Town, 7530, South Africa
TREAD Research (Pty) Ltd

Bellville, 7530, South Africa
Tekton Research, LLC

Denver, Colorado, 80238, United States
Tekton Research, LLC

Fort Collins, Colorado, 80525, United States
Tekton Research, LLC

Longmont, Colorado, 80501, United States
Tekton Research, LLC

Edmond, Oklahoma, 73013, United States
Tekton Research, LLC

Yukon, Oklahoma, 73099, United States
The Aurum Institute

Rustenburg, 0299, South Africa
The University of Nottingham Health Service

Nottingham, England, NG7 2QW, United Kingdom
Tiervlei Trial Centre

Bellville, 7530, South Africa
Triallogix Medical Corporation

Fullerton, California, 92835, United States
Tribe Clinical Research, LLC

Greenville, South Carolina, 29607, United States
Ubuntu Clinical Research

Lenasia, Gauteng, 1827, South Africa
University Hospital Southampton NHS Foundation Trust, NIHR Southampton Clinical Research Facility

Southampton, England, SO16 6YD, United Kingdom
University Hospitals Plymouth NHS Trust

Plymouth, England, PL6 8DH, United Kingdom
University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary

Leicester, England, LE1 5WW, United Kingdom
University of Witwatersrand, Clinical HIV Research Unit (CHRU), Helen Joseph Hospital

Johannesburg, Gauteng, 2092, South Africa
Velocity Clinical Research - Boise

Meridian, Idaho, 83642, United States
Velocity Clinical Research - Bristol

Bristol, England, BS8 2RA, United Kingdom
Velocity Clinical Research - Cleveland

Beachwood, Ohio, 44122, United States
Velocity Clinical Research - High Wycombe

High Wycombe, England, HP11 2QW, United Kingdom
Velocity Clinical Research - North London

London, England, N12 8BU, United Kingdom
Velocity Clinical Research - Omaha

Omaha, Nebraska, 68134, United States
Velocity Clinical Research - Romford

Romford, England, RM1 3PJ, United Kingdom
Velocity Clinical Research - Spartanburg

Spartanburg, South Carolina, 29303, United States
Velocity Clinical Research - Springdale

Cincinnati, Ohio, 45246, United States
Velocity Clinical Research - Valparaiso

Valparaiso, Indiana, 46383, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Wansford Research LTD

Peterborough, England, PE8 6PL, United Kingdom
Warrington and Halton Teaching Hospitals NHS Foundation Trust

Runcorn, England, WA7 2DA, United Kingdom
Welkom Clinical Trial Centre

Welkom, 9460, South Africa
West Clinical Research, Inc.

Morehead City, North Carolina, 28557, United States
Wilmington Health

Wilmington, North Carolina, 28412, United States
Windrush Medical Practice

Witney, England, OX28 6JS, United Kingdom
Zenos Clinical Research

Dallas, Texas, 75230, United States
hVIVO Services Limited

London, England, E1 1EQ, United Kingdom