Opportunistic mycosis

This Phase 2 trial tests whether a new drug called EL219 (Turletricin) is safe and effective for early treatment of invasive mould infections in people with weakened immune systems, such as those who have had a bone marrow transplant. About 60 participants will receive either EL2…

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

This study tests whether custom 3D-printed titanium implants can safely and effectively rebuild facial bones in 30 adults with defects from injury, cancer surgery, or birth conditions. Each implant is designed from CT scans to match the patient's unique anatomy. Researchers will …

This study tests a new gel called OCF001 for treating acute yeast infections in women. About 36 women with a confirmed yeast infection will use the gel or a placebo for 7 days. Researchers will check if the infection clears up and if the gel is safe and well-tolerated.

This Phase 3 trial tests a new drug called fosmanogepix against standard treatments for life-threatening Candida bloodstream or organ infections. About 450 adults will be randomly assigned to receive either fosmanogepix (first by IV, then as a pill) or the usual IV caspofungin fo…

This study tests a new medicine called fosmanogepix for adults with serious mold infections that are hard to treat. About 234 people will join, receiving either the new drug or standard care. The main goal is to see if fewer people die by day 42. The study is currently recruiting…

This study tests whether boric acid vaginal inserts (600 mg) taken for 7 or 14 days can safely and effectively treat yeast infections. About 400 women aged 12 and older with active symptoms will participate. The goal is to see if all signs and symptoms disappear without needing m…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This study tests whether adding one dose of a stronger antifungal drug (liposomal amphotericin) to the standard treatment (fluconazole) can prevent cryptococcal meningitis in HIV-positive adults who test positive for the fungus but have no symptoms. About 356 participants in Ugan…

This study tests a drug called benralizumab (Fasenra) in 20 adults with severe asthma and a fungal allergy called ABPA. The goal is to see if it can reduce asthma flare-ups that need steroids and improve quality of life. Participants receive the drug as a shot under the skin, and…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study compares a 7-day course of antifungal therapy to the standard 14-day course for children with uncomplicated candidemia (a blood infection caused by Candida fungus). About 420 children who have already received 7 days of treatment will be randomly assigned to stop or co…

This study looks at whether adding a biologic drug to standard treatment can reduce flare-ups in people with allergic bronchopulmonary aspergillosis (ABPA) and severe asthma. About 50 adults will receive a biologic for at least 4 months while continuing their usual asthma medicat…

This study looks at people with a mix of two lung conditions caused by the fungus Aspergillus: chronic pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Researchers want to see if adding steroid pills to the standard antifungal drug itraconazole works better th…

This early study tests whether a lactic acid gel (Phexxi) used twice weekly can change the vaginal microbiome to help prevent recurrent bacterial vaginosis and yeast infections. 22 premenopausal women with a history of these infections will use the gel for 4 weeks. Researchers wi…

This study is for people with a weakened immune system who have a serious lung infection called PCP. The standard treatment often causes bad side effects. Researchers want to see if a lower dose of the antibiotic TMP-SMX works just as well but with fewer side effects. About 416 a…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study is testing a new cooling device placed in the vagina to treat yeast infections. Researchers want to see if it can relieve symptoms and clear the infection within 7 days. The study involves 55 women aged 22-49 with uncomplicated yeast infections. It is an early-stage tr…

This study is for people with allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by an allergic reaction to a fungus. The treatment involves using a bronchoscope (a thin tube inserted into the airways) to clear mucus plugs and spray an antifungal drug (amphot…

This study looks at whether a single surgery to replace an infected hip or knee joint can work as well as the usual two-step process for Candida infections. Researchers will review records of 16 patients treated between 2013 and 2021. The goal is to see if the infection clears up…

This study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study tests whether a genetic test can help decide which leukemia patients need a strong antifungal drug (posaconazole) to prevent serious mold infections during chemotherapy. About 410 adults with acute myeloid leukemia will be randomly assigned to receive the drug or a pla…

This study tests a gel device called Multi-Gyn FemiTotal in 80 women with bacterial vaginosis or vaginal yeast infections. Participants use the gel for 7 days, and if symptoms clear, they are followed for 4 months to see if the infection returns. The goal is to see if the gel can…

This study tests whether a 5-day course of a nasal antiseptic (povidone iodine) can reduce or eliminate Candida auris, a drug-resistant fungus, from the nose of colonized patients. Researchers will enroll 120 adults with a history of C. auris colonization or infection. The goal i…

This study tests a combination of two antifungal drugs—liposomal amphotericin B plus either posaconazole or isavuconazole—in 60 adults with blood cancers who also have a serious fungal infection called mucormycosis. The goal is to see if the combo can clear the infection better a…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study evaluates a rapid diagnostic test that can detect Candida auris, a drug-resistant fungus, in about 15 minutes. Researchers will compare the test's accuracy against standard lab methods using samples from 554 patients. The goal is to help hospitals quickly identify and …

Mucormycosis is a serious fungal infection with a high death rate, and early treatment is critical. This study is testing a new blood test that looks for a unique sugar marker from the fungus. Researchers will compare results from 100 people—those with the infection, those at hig…

This study is testing whether a mouthwash or a nasal swab can accurately detect pneumocystis pneumonia (PcP) in immunocompromised patients. Currently, diagnosis often requires a bronchoscopy, which is invasive and uncomfortable. Researchers will compare the new non-invasive metho…

This study aims to see if a new PCR-based test can diagnose malaria, leishmania, and pneumocystis infections faster and more accurately than current methods. Researchers will analyze about 200 stored samples from patients. The goal is to improve diagnosis and species identificati…

This study tests a new type of PET scan that uses a radioactive fungal component to see if it can light up areas of Aspergillus infection in the body. Ten adults with suspected invasive fungal infections will receive the scan. The goal is to see if this method can accurately loca…

This study tests whether adding a probiotic supplement (Bioithas WOMAN®) to standard antifungal medicine helps relieve symptoms of vaginal yeast infections faster. About 60 women with suspected yeast infections will take either antifungal treatment alone or with the probiotic for…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study looks at whether a common yeast infection in babies' mouths, called oral thrush, is linked to severe cavities in early childhood. Researchers will follow 70 children, half with a history of thrush and half without, for two years. They will regularly check teeth and tak…

This study looks at 800 healthy adults who have cryptococcosis, a fungal infection that usually only harms people with weak immune systems. Researchers want to learn why these otherwise healthy people get sick, how their immune system responds, and how the disease progresses over…

This study aims to understand why some people get severe or unusual fungal infections due to immune system problems. Researchers will collect blood, tissue, and other samples from up to 1,200 participants over 25 years. No new treatments are being tested; the goal is to learn mor…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study is developing a machine learning model to predict the risk of relapse within one year for people with allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by an allergic reaction to a fungus. Researchers will collect data from 300 patients across mul…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at how the antifungal drug rezafungin moves into the abdominal fluid of critically ill patients with a serious fungal infection after abdominal surgery. Researchers will measure drug levels in the blood and belly fluid of 20 patients. The goal is to see if enough…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at how a common fungus called Aspergillus spreads in hospital wards and affects blood cancer patients. Researchers will take nasal swabs from 193 adults when they enter and leave the hospital, and also test the air in the ward. The goal is to find links between f…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study looks at how the immune system responds in critically ill patients with severe abdominal infections. Researchers want to understand why some patients develop a serious fungal infection while others do not. They will measure a specific immune marker (HLA-DR) in 100 adul…

This study examines whether chest CT scans can help predict how patients with a rare but severe lung fungal infection called pulmonary mucormycosis will fare. Researchers will review scans from 80 patients treated at a French hospital to identify imaging patterns linked to better…

This study looks at whether measuring Aspergillus fumigatus DNA in blood or lung fluid can help predict outcomes in patients with invasive aspergillosis, a serious fungal lung infection. Researchers will track 100 adults to see if changes in PCR levels during treatment relate to …

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18–80 and follow them for 6 months. The goal …

This study is creating a data bank to better understand vaginal conditions like vulvodynia, yeast infections, bacterial vaginosis, and preterm labor. Researchers will look at proteins, immune markers, and vaginal bacteria in 550 women, including healthy volunteers and those with …

This study aims to better understand bronchiectasis, a chronic lung disease, in Chinese patients. Researchers will collect data from 1500 adults to identify different disease types and their underlying causes. The goal is to improve diagnosis and tailor treatments for each patien…

This study monitors the immune system of 20 adults with serious mold infections (like Aspergillus) to see how their T cells respond. The goal is to find out which patients might benefit from adding immunotherapy to standard antifungal drugs. Researchers will measure immune checkp…

This study is trying to understand why some people with severe flu in the ICU develop a dangerous fungal lung infection called aspergillosis. Researchers will compare the immune systems of 45 flu patients and non-flu pneumonia patients in the ICU. They hope to find differences in…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…