Opportunistic mycosis

This study tests a new vaccine called Candi5V in 251 women who get frequent yeast infections (at least 3 per year). The vaccine is designed to train the body's immune system to fight Candida fungus. Researchers will check if it's safe and if it reduces future infections.

This study tests a drug called rezafungin for people with a long-term lung infection caused by a fungus (chronic pulmonary aspergillosis) who have few other treatment choices. About 60 adults will receive the drug once a week for 6 months. Researchers will check if the treatment …

This study compares a shortened steroid regimen (8 days for moderate, 14 days for severe pneumonia) against the standard 21-day course in 196 HIV patients with Pneumocystis pneumonia. The goal is to see if the shorter treatment is non-inferior in preventing death and complication…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This study tests a new drug called olorofim against a standard treatment (AmBisome followed by usual care) for a serious lung infection caused by Aspergillus fungus. About 225 adults with proven or probable infection will take part. The main goal is to see if olorofim reduces dea…

This study tests a product called pHyph for treating thrush (a vaginal yeast infection) in adult women. The goal is to see if pHyph reduces symptoms like itching, burning, and irritation. 48 women will either use pHyph daily for 6 days or receive no treatment, and researchers wil…

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study looks at 120 Canadian women to understand why some get repeated yeast infections while others don't. Researchers will compare the vaginal yeast and bacteria of women with their first infection, those with recurrent infections, and those with yeast but no symptoms. Part…

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study looks at why people with severe liver disease who are in the intensive care unit (ICU) are at risk for a dangerous fungal lung infection called invasive pulmonary aspergillosis. Researchers will study 450 patients to find better ways to predict, diagnose, and treat thi…

This study was designed to learn more about different types of Candida fungus that cause serious bloodstream infections, and how they become resistant to medicines. The researchers planned to study samples from adult patients to track which species were most common and how they r…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study looks back at medical records of 150 people treated for mucormycosis, a rare but serious fungal infection. Researchers compare two drugs—amphotericin B and isavuconazole—to see which leads to better survival and fewer side effects. The goal is to help doctors choose th…