Could 7 days of antifungals be enough for kids with blood infections?
NCT ID NCT05763251
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a 7-day course of antifungal therapy to the standard 14-day course for children with uncomplicated candidemia (a blood infection caused by Candida fungus). About 420 children who have already received 7 days of treatment will be randomly assigned to stop or continue for another week. The goal is to see if the shorter treatment is just as effective, which could mean fewer side effects and less time in the hospital.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antifungal therapy (echinocandin)
What this could lead to
If successful, this could show that a shorter course of antifungal treatment is just as effective as the standard longer course for children with uncomplicated candidemia, potentially reducing side effects and hospital stays.
What could go wrong
This is a phase 2/3 trial, so results are not yet proven. The shorter course might not be as effective, leading to higher relapse rates. The study also uses a biomarker test that may not be perfectly accurate.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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CS Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 31193, United States
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Children's Hospital of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
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Children's Hospital of Orange County
RECRUITINGOrange, California, 92868, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Cincinnati Children's Hospital
RECRUITINGCincinnati, Ohio, 45229, United States
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Comer Children's Hospital
RECRUITINGChicago, Illinois, 60637, United States
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Dell Children's Medical Center
RECRUITINGAustin, Texas, 78723, United States
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Duke Children's Hospital
RECRUITINGDurham, North Carolina, 27705, United States
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Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Perth Children's Hospital
RECRUITINGPerth, Western Australia, 6009, Australia
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Riley Children's Hospital
RECRUITINGIndianapolis, Indiana, 46202, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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Washington University St. Louis
RECRUITINGSt Louis, Missouri, 63130, United States
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Weill Cornell Medical College
RECRUITINGNew York, New York, 10065, United States
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Yale New Haven Children's Hospital
RECRUITINGNew Haven, Connecticut, 06510, United States