Arkansas Children's Hospital Research Institute

This study tests whether adding the drug ruxolitinib to a standard stem cell transplant can prevent graft failure in children and young adults with severe sickle cell disease. Up to 24 participants will receive the drug during conditioning and be followed for two years after tran…

This study compares a 7-day course of antifungal therapy to the standard 14-day course for children with uncomplicated candidemia (a blood infection caused by Candida fungus). About 420 children who have already received 7 days of treatment will be randomly assigned to stop or co…

This study tests a tailored physical activity program for children ages 3 to 5 whose mothers have obesity. The program includes fun movement games and simple nutrition tips to help kids build motor skills and healthy habits. Researchers will compare 266 families who get the progr…

This study tests a structured exercise program for pregnant women with obesity who are not very active. The program, called COMMUNITY EXPECTING, includes aerobic and strength exercises delivered at local fitness centers or community programs. Researchers want to see if it helps w…

This study compares stevia-sweetened drinks, sugary drinks, and flavored water in children ages 8-12 who regularly drink sugary beverages. Over 8 to 14 weeks, researchers will measure changes in weight, body fat, insulin resistance, blood fats, and blood pressure. The goal is to …

This study looks at how a serious burn injury changes the way cells produce energy. Researchers will collect blood, urine, and tissue samples from 125 children and adults admitted to the burn center. No new treatments are tested; the goal is simply to learn more about the body's …

This study looks at how new cystic fibrosis drugs work in children ages 2 and older. Researchers want to find genetic clues that can tell us ahead of time who will respond well, so kids don't get unnecessary side effects or high costs from treatments that won't help them. About 1…

This study looks at whether children and young adults (up to age 21) treated for B-cell acute lymphoblastic leukemia with the immunotherapy drug blinatumomab still have protection from routine childhood vaccines. Researchers will measure antibody levels for diseases like tetanus,…

This study looks at whether current protein recommendations for children ages 8-10 are too low, especially for those who are very active and fit. Researchers will measure how the body uses protein in 30 healthy kids with different activity levels. The goal is to better understand…

This study is testing whether teaching women with excess weight to hand express colostrum during late pregnancy can improve breastfeeding initiation and duration. It also examines how a mother's diet affects her breast milk composition and her baby's growth. About 240 pregnant wo…

This study follows 2,000 children who have had or will have a stem cell or organ transplant. Researchers will test for respiratory viruses before and after transplant to see if they can predict who will get a serious lung infection. The goal is to improve screening and care, not …

This study is testing whether a program originally designed for clinics can work in community settings to help pregnant women with a BMI over 30 stay active and healthy. Researchers will enroll 60 expecting mothers to see if the program is easy to use and follow. The goal is to l…