Could a painkiller stop the cough that Won't quit in lung fibrosis?

NCT ID NCT07671911

Recruiting now Symptom relief Sponsor: Trevi Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether an extended-release form of nalbuphine, a pain medication, can safely reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. About 306 adults with IPF and a cough lasting at least 8 weeks will receive either the drug or a placebo for 26 weeks. The main goal is to see if the drug lowers the number of coughs per day.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nalbuphine extended-release tablets
What this could lead to: If it works, this could provide a new treatment option to ease chronic coughing in people with idiopathic pulmonary fibrosis, improving their quality of life.
What could go wrong: This is a Phase 3 trial, but it's still experimental. The drug may not reduce cough significantly, and side effects like drowsiness or dizziness are possible.

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS

Contacts and locations

Locations

Clinical Research and Associates, Inc.
RECRUITING

Miami, Florida, 33126, United States
Clinical Research of Gastonia (CRG)
RECRUITING

Gastonia, North Carolina, 28054, United States
El Paso Pulmonary Association, PA
RECRUITING

El Paso, Texas, 79902, United States
Elevate Clinical Research
RECRUITING

Houston, Texas, 77058, United States
Pulmonary Specialists of The Palm Beaches
RECRUITING

Loxahatchee Groves, Florida, 33470, United States

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