New hope for chagas: experimental drug aims to wipe out parasites
NCT ID NCT06632600
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug called LXE408 in 130 adults with chronic Chagas disease who do not have severe organ damage. The goal is to see if LXE408 can clear or reduce the parasite level in the blood over 6 months, compared to placebo and standard treatment. Participants take the drug by mouth for 28 days, and researchers check for parasites using a sensitive test (PCR) at several time points.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LXE408 (an experimental oral drug)
What this could lead to
If successful, this could provide a new treatment option for chronic Chagas disease, potentially reducing parasite levels and preventing disease progression.
What could go wrong
This is an early Phase 2 trial with only 130 participants, so results may not apply to everyone. The drug may not clear parasites as hoped, and side effects are still being studied.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-••••
Locations
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030-3411, United States
Contact
Contact Email: •••••@•••••
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Boston Medical Center
RECRUITINGBoston, Massachusetts, 02118, United States
Contact
Contact Email: •••••@•••••
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Novartis Investigative Site
RECRUITINGCABA, Buenos Aires, 1407, Argentina
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Novartis Investigative Site
RECRUITINGCABA, Buenos Aires, C1221ADC, Argentina
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Novartis Investigative Site
RECRUITINGCaba, C1015ABO, Argentina
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Novartis Investigative Site
RECRUITINGCorrientes, W3400CDS, Argentina
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Novartis Investigative Site
RECRUITINGCórdoba, X5016KEH, Argentina
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Novartis Investigative Site
RECRUITINGFormosa, P3600KGC, Argentina
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Novartis Investigative Site
RECRUITINGMontes Claros, Minas Gerais, 39401-001, Brazil
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Novartis Investigative Site
RECRUITINGRecife, Pernambuco, 50100-060, Brazil
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Novartis Investigative Site
RECRUITINGRio de Janeiro, Rio de Janeiro, 21040-360, Brazil
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Novartis Investigative Site
RECRUITINGSão Caetano do Sul, São Paulo, 09521-160, Brazil
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Novartis Investigative Site
RECRUITINGBarranquilla, Atlántico, 080005, Colombia
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Novartis Investigative Site
RECRUITINGYopal, Casanare Department, 850009, Colombia
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Novartis Investigative Site
RECRUITINGBogotá, 110131, Colombia
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Novartis Investigative Site
RECRUITINGBogotá, 111411, Colombia
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Novartis Investigative Site
RECRUITINGFloridablanca, 681017, Colombia
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Novartis Investigative Site
RECRUITINGSan Gil, 684031, Colombia
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Olive View UCLA Educ and Res Ins
RECRUITINGSylmar, California, 91342, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida Shands
RECRUITINGGainesville, Florida, 32610-0486, United States
Contact Email: •••••@•••••
Contact