Chagas drug shows promise for kids in landmark trial
NCT ID NCT04024163
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the drug benznidazole can cure chronic Chagas disease in children aged 2 to 18. All 178 participants receive the drug, and their results are compared to a historical placebo group. The main goal is to see if the infection clears based on blood tests over 72 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Benznidazole
What this could lead to
If successful, this could confirm benznidazole as an effective treatment to clear Chagas infection in children, potentially preventing long-term heart and digestive complications.
What could go wrong
This is a single-arm study with historical controls, not a randomized blinded trial, so results may be less reliable. The follow-up is long (72 months), and serological cure may not fully predict clinical outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Antigua Hospital Viedma
Cochabamba, Bolivia
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CEADES - Plataforma de Chagas Sucre
Sucre, Bolivia
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Centro de Atención e Investigación Médica (CAIMED)
Yopal, Colombia
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Centro de Enfermedad de Chagas y Patologías Regionales
Santiago del Estero, Argentina
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Fundación Salud para el Trópico
Santa Marta, Colombia
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Hospital "Luis Carlos Lagomaggiore"
Mendoza, Argentina
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Hospital Pediatrico "Dr. Humberto Notti"
Mendoza, Argentina
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Hospital Público Descentralizado Dr. Guillermo Rawson
San Juan, Argentina
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Hospital de Ninos "Dr. Ricardo Gutierrez"
Buenos Aires, Argentina