Chagas drug shows promise for kids in landmark trial

NCT ID NCT04024163

Ongoing Disease control Sponsor: Insud Pharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug benznidazole can cure chronic Chagas disease in children aged 2 to 18. All 178 participants receive the drug, and their results are compared to a historical placebo group. The main goal is to see if the infection clears based on blood tests over 72 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Benznidazole
What this could lead to: If successful, this could confirm benznidazole as an effective treatment to clear Chagas infection in children, potentially preventing long-term heart and digestive complications.
What could go wrong: This is a single-arm study with historical controls, not a randomized blinded trial, so results may be less reliable. The follow-up is long (72 months), and serological cure may not fully predict clinical outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chagas disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHAGAS DISEASE

Contacts and locations

Locations

Antigua Hospital Viedma

Cochabamba, Bolivia
CEADES - Plataforma de Chagas Sucre

Sucre, Bolivia
Centro de Atención e Investigación Médica (CAIMED)

Yopal, Colombia
Centro de Enfermedad de Chagas y Patologías Regionales

Santiago del Estero, Argentina
Fundación Salud para el Trópico

Santa Marta, Colombia
Hospital "Luis Carlos Lagomaggiore"

Mendoza, Argentina
Hospital Pediatrico "Dr. Humberto Notti"

Mendoza, Argentina
Hospital Público Descentralizado Dr. Guillermo Rawson

San Juan, Argentina
Hospital de Ninos "Dr. Ricardo Gutierrez"

Buenos Aires, Argentina

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