Could a longer course of vaginal progesterone cut preterm births in IVF?
NCT ID NCT05787509
First seen Jun 16, 2026 · Last updated Jun 23, 2026 · Updated 1 time
Summary
This study tests whether giving vaginal progesterone gel for a longer time can prevent preterm birth in women who became pregnant through IVF with a fresh embryo transfer. About 100 women aged 20-40 with a single pregnancy will be enrolled. Researchers will compare preterm birth rates and live birth outcomes between those who receive extended progesterone treatment and those who do not.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Sun Yat-sen Memorial Hospital
RECRUITINGGuangzhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
progesterone sustained-release vaginal gel
What this could lead to
If it works, this could offer a simple way to reduce preterm births in IVF pregnancies, improving outcomes for mothers and babies.
What could go wrong
This is a small, early-phase trial with only 100 participants, so results may not apply to everyone. Progesterone is generally safe but may cause mild side effects like irritation or drowsiness.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.