Ohio State University

This study tests two programs—mindfulness training and a heart-healthy diet plan—to help Black women caregivers lower their blood pressure and stress. About 90 participants will join weekly group sessions online for 8 weeks, with follow-up calls. The goal is to see if these appro…

This study tests whether a cochlear implant can safely and effectively restore hearing in people who become deaf in one ear after surgery to remove a benign tumor (vestibular schwannoma) or to treat Meniere's disease. Fifteen participants will receive the implant during their sur…

This study looks at whether eating three soybean-oil-based foods each day for 16 weeks can lower fat buildup in the liver and belly fat in people with nonalcoholic fatty liver disease. Participants keep their usual weight during the trial. The goal is to see if changing the type …

This phase 2 trial tests whether a single, low dose of radiation to the chest can reduce lung inflammation in hospitalized COVID-19 pneumonia patients. Researchers compare two radiation doses (35 cGy and 100 cGy) to standard care. The goal is to see if this treatment lowers the n…

This study tests three ways emergency responders help children breathe: a bag-mask, a throat tube, or a breathing tube. It includes 3,000 children under 18 with cardiac arrest, severe injury, or breathing failure. The goal is to see which method leads to more days alive and out o…

This study tests a program where African American adults with type 2 diabetes and a family member work together to manage the condition. The program focuses on daily self-care, healthy eating, walking, and better communication. Researchers want to see if it improves blood sugar c…

This study is testing a step-based care model for 100 people aged 12-25 who are at high risk for psychosis. Participants start with low-intensity support and move to stronger treatments only if needed, with the goal of reaching remission. Researchers will track symptom relief and…

This study compares two types of spinal fusion cages used in back surgery: a new titanium cage with a special rough surface and a standard plastic cage. About 100 adults with spine problems like narrowing of the spinal canal or slipped vertebrae will be randomly assigned to recei…

This study tracks 75 nearsighted young adults over 12 months to see how low-dose atropine eye drops or soft multifocal contact lenses affect the shape of the eye. Participants are randomly assigned to one of these treatments or no treatment. Researchers will take eye photos and m…

This study tests a peer mentoring program to help rural Appalachian children with overweight or obesity become more active. Over 400 seventh graders will receive virtual mentoring sessions and family support to increase daily physical activity and reduce sugary drinks. The goal i…

This study tests two types of donated human tissue grafts for treating gum recession. Twenty adults who need a gum graft will receive either a standard graft or a new micro-surfaced version. Researchers will compare how well the gum covers the tooth root, how the site heals, and …

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This study tests whether an 8-week internet-based mindfulness program (iMBSR) can improve brain health in adults aged 50 and older who have subjective cognitive decline, a potential early sign of Alzheimer's disease. Sixty participants will be randomly assigned to either the mind…

This study looks at whether a ketone ester supplement can help people think clearly and perform physical tasks after four nights of reduced sleep. Researchers will give the drink to 60 military participants and measure their cognitive skills, reaction time, and marksmanship. The …

This study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help veterans with PTSD. Fifteen veterans will receive two doses of psilocybin in a supervised therapy setting. Researchers will monitor side effects and measure changes in PTSD symptoms.

This study tests whether using a breathing muscle training device, along with standard physical therapy, helps people recover more quickly after a lung transplant. About 90 adults waiting for a lung transplant will take part. The goal is to see if this training improves breathing…

This study looks at whether a procedure called pancreatic endotherapy (using a thin tube through the mouth to treat the pancreas) can improve quality of life and reduce pain in 32 adults with chronic pancreatitis. Participants will fill out pain diaries and quality-of-life survey…

This study looks at how different ketone supplements affect blood ketone levels in healthy young men. Researchers want to understand which supplements raise ketones the most and how the body processes them. The study involves 14 men aged 20-30 with a healthy BMI. Results will hel…

This study follows 400 patients for two years after they have endoscopic endonasal skull base surgery (surgery through the nose to reach the base of the skull). The goal is to measure their quality of life and nose function using standard questionnaires. It does not test a new tr…

This study tests a computer tool that uses maps and location data to help infection preventionists find and stop hospital-acquired infections faster. About 25 infection prevention staff will use the tool and report how easy it is to use and whether it helps them respond more quic…

This study looks at what happens when healthy adults eat special cookies every day for two weeks. Researchers want to see if these cookies can increase a healthy fat called linoleic acid in the blood. The study involves 123 non-smoking adults without major health conditions.

This small pilot study looks at how eating foods made with soybean oil or palm oil every day for four weeks changes blood fatty acids and body weight in overweight adults. Sixteen participants will try both oils in a crossover design. The goal is to see if people can stick with t…

This study uses advanced heart MRI scans to look for the earliest signs of dilated cardiomyopathy (a weakened heart muscle) in close relatives of people already diagnosed. Researchers will follow 650 family members over time to see how genetic factors relate to heart changes. The…

This study looks at whether eating one special healthy cookie each day for two weeks can improve how your cells make energy. It involves 24 healthy adults who do not smoke. The goal is to learn, not to treat or cure any disease.

This observational study looks at how diet, activity, and lifestyle factors relate to muscle strength and heart health in 14 postmenopausal breast cancer patients who received anthracycline chemotherapy. Researchers will measure changes in heart function, muscle energy, and blood…

This study looks at whether pretzels made with safflower oil and soy can help postmenopausal women with metabolic syndrome maintain a healthy weight. Twenty women will eat three different types of pretzels over 14 weeks, and researchers will measure how their bodies process the s…

This study looks at how well a bioimplant helps heal hip tendons after surgery. Fifteen adults with torn gluteal tendons will get the implant during standard repair. Researchers will use ultrasound and questionnaires to check tissue healing and hip function over time.

This study checks whether a play-based test of arm and hand movements, called the Melbourne Assessment-2, is reliable when done through telehealth for children with hemiplegic cerebral palsy. About 35 children ages 2 to 10 will attend one in-person visit and one telehealth visit,…

This observational study will enroll 400 military personnel and civilians to compare motion and health history between those with low back or neck pain and those with healthy spines. Participants wear a motion monitor and complete questionnaires over one year. The goal is to deve…

This study looks at how to help primary care clinics screen more adults for substance use problems. It compares different support strategies like coaching, team learning, and financial rewards. 144 clinic staff from 48 practices will take part. The goal is to find the best way to…

This study looks at how chronic bilateral knee pain changes the brain's ability to recognize left from right, and whether dry needling can improve movement and muscle function. Sixty adults aged 18 to 40 with patellofemoral pain will be split into groups based on their fear of mo…

This study looks at how chemicals and social factors before birth may affect brain function and mental health in teenagers. Researchers will use brain scans and behavior questionnaires in 250 adolescents aged 13-20. The goal is to understand pathways linking early exposures to ps…

This study looks at whether genes and thinking skills like memory can predict how well someone with aphasia (trouble speaking after a stroke) responds to word-retrieval therapy. Researchers will work with 120 people who had a stroke at least six months ago. The goal is to move to…

This study looks at how people's eyes move when they watch videos of a baseball pitcher throwing. Researchers want to see if experienced baseball players are better at moving their eyes to the ball release point before the pitch happens compared to people who don't play baseball.…

This study involves 24 healthy, non-smoking adults who will give blood samples through a standard blood draw and finger sticks (some done at home and mailed in). Researchers want to improve how they measure fatty acids and energy use in blood cells. The goal is to make remote blo…

This study looks at whether giving Fitbit smartwatches to adults aged 65 and older in a doctor-referred exercise program can help them become more active. Researchers will track how many people join, attend, and complete the program, and how they feel about using the watch. The g…

This study looks at how eating whole wheat bread affects gut bacteria and health in adults with prediabetes. 65 participants will eat either whole wheat or white bread for two weeks, then provide stool, urine, and blood samples. The goal is to see if whole wheat can improve blood…

This study looks at whether giving staff bonuses for hitting targets helps them deliver better substance use counseling to people with HIV. Researchers are comparing two strategies: one with just training and feedback, and another that adds monetary incentives. The goal is to see…

This study was designed to see how well continuous glucose monitors (CGMs) work for pregnant women with gestational diabetes who need medication. It planned to compare blood sugar patterns in women taking metformin versus insulin during pregnancy and after delivery. However, the …

This study looks at whether tangerine tomatoes, which have a different form of lycopene, are more easily absorbed by the body than red tomatoes. Twelve healthy adults will drink either tangerine or red tomato juice and have their blood tested over 12 hours. The goal is to see whi…

This early-phase study tests whether strawberry gummies can improve oral health in 36 adults, including smokers and non-smokers. Participants eat two types of gummies (real strawberry or placebo) four times daily for a week. Researchers measure how the body absorbs strawberry com…

This study looks at millions of medical records to see if GLP-1 agonists (like Ozempic) and SGLT2 inhibitors (like Jardiance) affect heart, kidney, and metabolic health differently in men versus women. Participants are adults with early-stage cardiovascular-kidney-metabolic syndr…