Ohio State University

This study tests a program where older kids mentor younger ones to be more active, with family support to keep it going at home. It involves 432 seventh graders in rural Appalachian areas who are overweight or have obesity. The goal is to increase daily physical activity and impr…

This study tests a new type of gum graft material (microsurfaced acellular dermal matrix) against the standard material for covering exposed tooth roots. Twenty adults needing gum grafts will be randomly assigned to receive one of the two materials. Researchers will measure how w…

This study tests whether a single low-dose radiation treatment to the lungs can reduce inflammation in adults hospitalized with COVID-19 pneumonia. The goal is to see if this approach lowers the need for a breathing tube or shortens hospital stays. About 37 participants will rece…

This study compares three emergency breathing techniques used by paramedics for children in cardiac arrest, severe injury, or respiratory failure. About 3000 children will be enrolled to see which method leads to more days alive and out of the ICU within 30 days. The goal is to f…

This study tests two programs—mindfulness exercises and a heart-healthy diet (DASH)—to help Black women who care for a loved one with Alzheimer's or memory problems. Participants are 40 or older, have high blood pressure, and provide unpaid care. The goal is to lower blood pressu…

This study tests a program called B-SWELL, designed to help midlife Black women (ages 45-64) lower their heart disease risk by reducing stress and adopting healthier habits. Participants are randomly placed into either the B-SWELL program or a general wellness group, both lasting…

This study compares two types of implants used in spine surgery: a new titanium cage with a special rough surface and a standard plastic cage. About 100 adults with spine problems like narrowing of the spinal canal or worn-out discs will be randomly assigned to receive one of the…

This study looks at whether eating three soybean-oil-based foods each day for 16 weeks can reduce fat buildup in the liver and belly fat in people with nonalcoholic fatty liver disease. Participants keep their weight stable during the trial. The goal is to see if changing the typ…

This study tests whether having a family member or close friend join in diabetes self-management training helps African American adults with type 2 diabetes improve their blood sugar control and quality of life. About 208 participants and their family partners will take part. The…

This study looks at whether a cochlear implant can safely and effectively help people hear again after surgery that leaves them deaf in one ear. Participants are having a tumor removed or a procedure for Meniere's disease that causes complete hearing loss on that side. They recei…

This study looks at whether a procedure called pancreatic endotherapy (using a scope to treat the pancreas) can improve quality of life and reduce pain in people with chronic pancreatitis. About 32 adults with painful chronic pancreatitis will be treated and followed for a year. …

This study looks at whether using a special breathing trainer, along with standard physical therapy, helps people who just had a lung transplant. The goal is to see if it improves breathing muscle strength, reduces shortness of breath and fatigue, and helps them get back to daily…

This study looks at whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely help veterans with PTSD. Fifteen veterans will receive the treatment and be monitored for side effects and changes in PTSD symptoms. The goal is to see if this appro…

This study looks at whether an 8-week mind-body course, including yoga and mindfulness, can reduce stress, burnout, and muscle pain in university dance students. About 40 second- and third-year dance majors at Ohio State University will take the course as part of their regular cl…

This study looks at how two common myopia treatments—low-dose atropine eye drops and soft multifocal contact lenses—change the shape of the eye in nearsighted young adults. About 75 participants will be randomly assigned to use one of these treatments or no treatment, and researc…

This study looks at how chemicals and social factors before birth affect brain function and behavior in teenagers. Researchers will use brain scans and questionnaires in 250 adolescents aged 13-20. The goal is to understand pathways that may increase risk for psychiatric problems…

This study is testing a specialized program for people aged 12-25 who show early signs that may lead to psychosis. The program uses a step-based approach to provide care tailored to each person's needs. Researchers will track participants for up to 24 months to see if symptoms an…

This study tests whether giving staff financial bonuses for meeting goals helps them deliver better substance use counseling to people with HIV. About 428 staff and clients took part. The main focus is on how consistently and how well the counseling is given, not on directly trea…

This study looks at how eating whole wheat bread changes gut bacteria and health markers in adults with prediabetes. Over two weeks, 65 participants will eat either whole wheat or white bread daily, then provide stool, urine, and blood samples. The goal is to understand how whole…

This study tests a new computer tool that uses maps to help infection preventionists find and stop hospital-acquired infections faster. About 25 infection experts will use the tool and report on how easy it is to use and whether it helps them respond more quickly. The goal is to …

This observational study looks at how diet, activity, and lifestyle factors relate to muscle strength and heart health in 14 postmenopausal women treated for early-stage breast cancer with a specific type of chemotherapy. Participants will undergo MRI scans and provide blood and …

This study looks at whether an 8-week online mindfulness program can improve brain health in adults aged 50 and older who have noticed some memory or thinking changes. Sixty participants will be randomly assigned to either the mindfulness program or a general lifestyle education …

This pilot study tests whether eating one healthy cookie each day for two weeks can improve the energy centers (mitochondria) in blood and muscle cells. The cookies are made with an oil rich in linoleic acid. The study involves 24 healthy adults who do not smoke and have no food …

This study tests whether a point-of-view simulation can reduce stigma and improve empathy among pharmacists and pharmacy students when caring for sickle cell patients with chronic pain. About 200 healthcare professionals or students will complete a survey before and after the sim…

This study is testing better ways to measure fats and energy use in blood samples from healthy adults. Participants will give blood through a standard vein draw and finger pricks, including one done at home using a mail-in kit. The goal is to improve lab methods for analyzing fat…

This study looks at health records from over 23 million people to see if common heart and kidney drugs (GLP-1 agonists and SGLT2 inhibitors) affect men and women differently. Researchers want to understand if these drugs work equally well for both sexes in preventing heart attack…

This study looks at how people's eyes move when they watch videos of a baseball pitcher throwing. Researchers want to see if experienced baseball players are better at moving their eyes to the ball release point before the pitch happens compared to people who don't play baseball.…

This study looks at how pretzels made with safflower oil and soy affect energy use in postmenopausal women who are overweight and have metabolic syndrome. Twenty women will eat different pretzels for one month each to see how their bodies digest them. The goal is to learn if thes…

This study looks at how chronic knee pain on both sides changes the way the brain recognizes left from right, and how dry needling might affect movement and muscle function. Researchers will test 60 adults aged 18 to 40 with and without knee pain. Participants complete one 2-hour…

This study looks at whether certain genes and thinking skills, like memory, can predict how well someone with aphasia (trouble speaking after a stroke) will respond to therapy. About 120 people who had a stroke at least six months ago will take part. The goal is to help doctors p…

This study looks at whether giving Fitbit smartwatches to adults aged 65 and older in a doctor-referred exercise program helps them become more active. Researchers will track how many people join, attend, and finish the program, and whether they find the smartwatch helpful. The g…

This study looks at how well wearable motion monitors can track recovery and predict return to duty in military members with low back or neck pain. Researchers will compare motion data and health history from 400 participants with and without spine pain. Participants wear a motio…

This study looks at how well a torn hip tendon heals after surgery when a special bioimplant is used to support the repair. Fifteen adults with large tendon tears will have the surgery and be followed with ultrasound scans and questionnaires. The goal is to see if the implant hel…

This study looks at different methods to help primary care clinics better screen patients for substance use disorders. Researchers will compare approaches like practice coaching, group learning, and financial rewards. The goal is to find the best way to increase screening rates a…

This study looks at how eating foods made with soybean oil or palm oil for 4 weeks changes blood fats and body weight in overweight adults. Sixteen people will eat three study foods each day. The goal is to see if these oils affect health differently and if people can tell which …

This study looks at what happens when healthy adults eat special cookies every day for two weeks. Researchers want to see if these cookies can raise a healthy fat called linoleic acid in the blood. The study does not test a treatment or cure—it simply gathers information about ho…

This study looks at whether a play-based test of arm and hand movements, called the Melbourne Assessment-2, works just as well when done through telehealth as in person. About 35 children with hemiplegic cerebral palsy, ages 2 to 10, will attend one in-person visit and one telehe…

This study looks at how well blood sugar is controlled in pregnant women with gestational diabetes who are treated with either metformin or insulin. Researchers will use a continuous glucose monitor to track blood sugar levels during pregnancy and after childbirth. The goal is to…

This study uses advanced heart MRI scans to look for the earliest signs of dilated cardiomyopathy (a weakened, enlarged heart) in close relatives of people who have the condition. Researchers will scan 650 family members to see if certain genetic changes are linked to early heart…

This study looks at whether tangerine tomatoes, which are orange, provide nutrients like lycopene and flavonoids that are easier for the body to absorb compared to regular red tomatoes. Researchers will give 12 healthy adults meals made from either tangerine or red tomato juice a…

This study looks at whether eating special strawberry gummies can improve oral health and reduce risks of gum disease or oral cancer. Researchers will test two types of gummies—one with real freeze-dried strawberries and one without—in 36 adults who smoke or have never smoked. Th…