Your DNA may hold the key to better stroke recovery
NCT ID NCT05179538
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This study looks at whether genes and thinking skills like memory can predict how well someone with aphasia (trouble speaking after a stroke) responds to word-retrieval therapy. Researchers will work with 120 people who had a stroke at least six months ago. The goal is to move toward personalized medicine, where therapy is tailored to each person's biology.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2020
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * At least six months post-onset of a single left-hemisphere stroke * Chronic aphasia * Anomia (word-retrieval deficits) * Native English Speaker. Exclusion Criteria: * Severe motor speech disorders * Severe auditory comprehension deficits * Severe depression. * Diffuse injury or disease of the brain * Uncorrected vision or hearing difficulties * Contraindications for MRI (e.g. cardiac pacemaker, ferrous metal implants, claustrophobia, pregnancy).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Ohio State University
Columbus, Ohio, 43210, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can hearing your own voice rewire speech after a stroke?
- Zapping the brain to restore speech after stroke?
- Can exercise boost reading recovery in stroke survivors?
- Can training the brain to think about words boost recovery from stroke-related aphasia?
- Can an AI app give a voice to brain tumor patients?
- Brain zaps may unlock lost words after stroke