Can a Brain-Calming drug help Parkinson's patients walk better?
NCT ID NCT01108029
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether memantine, a drug that reduces overactive brain signals, can improve walking and attention in people with advanced Parkinson's disease. Twenty-eight non-demented patients with severe gait issues took memantine or a placebo for three months. The goal was to see if the drug could ease freezing of gait and attention deficits, potentially leading to larger studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
memantine (a drug that blocks excess glutamate in the brain)
What this could lead to
If it works, this could point toward a new way to ease walking problems and attention issues in advanced Parkinson's disease.
What could go wrong
This is a small, early pilot study with only 28 participants. The results may not apply to all Parkinson's patients, and memantine might not show clear benefits.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Devos
Lille, 59037, France