New combo sedation tested for brain surgery patients

NCT ID NCT07513935

Ongoing Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a combination of two sedatives (ketamine and dexmedetomidine, called Ketodex) works better than dexmedetomidine alone for keeping patients comfortable during awake deep brain stimulation surgery. The surgery is used for movement disorders like Parkinson's disease. Twenty-four adults will be randomly assigned to one of the two sedation groups, and researchers will measure how well the brain signals are recorded and how much extra pain medicine is needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ketodex (ketamine and dexmedetomidine combination)
What this could lead to: If successful, this could show that adding ketamine to dexmedetomidine provides better sedation and comfort during awake brain surgery without interfering with brain recordings.
What could go wrong: This is a small Phase 4 trial with only 24 participants, so results may not apply to everyone. The study is also not recruiting, meaning findings may take time to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

essential tremor Intraoperative Awareness Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRAOPERATIVE AWARENESS

Contacts and locations

Locations

Ainshams University

Cairo, Egypt

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