Promising antibody trial aims to halt Parkinson's progression

NCT ID NCT07174310

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 26 times

Summary

This study tests an experimental drug called prasinezumab in 900 people with early-stage Parkinson's disease who are already on stable levodopa therapy. The goal is to see if the drug can delay worsening of motor symptoms compared to a placebo. Participants receive the drug or placebo by IV infusion, and researchers track changes in movement over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O. Universitaria Pisana
RECRUITING

Pisa, Tuscany, 56126, Italy
APHP - Hopital Henri Mondor
RECRUITING

Créteil, 94010, France
Aarhus Universitetshospital Skejby
RECRUITING

Aarhus N, 8200, Denmark
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona
RECRUITING

Salerno, Campania, 84131, Italy
Azienda Ospedaliera Spedali Civili
RECRUITING

Brescia, Lombardy, 25100, Italy
Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States
Beijing Friendship Hospital Affiliated of Capital University of Medical Science
RECRUITING

Beijing, 100050, China
Beijing Hospital of Ministry of Health
RECRUITING

Beijing, 100730, China
Beijing Tian Tan Hospital,Capital Medical University
RECRUITING

Beijing, 100071, China
Bispebjerg Hospital;Neurologisk Afdeling
RECRUITING

København NV, 2400, Denmark
Boramae Medical Center
RECRUITING

Seoul, 07061, South Korea
CHU de Montpellier - Hôpital Gui de Chauliac
RECRUITING

Montpellier, 34295, France
CHUM
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
CNS - Campus Neurológico
RECRUITING

Torres Vedras, 2560-280, Portugal
Campus for Ageing and Vitality
RECRUITING

Newcastle, NE4 5PL, United Kingdom
Central Texas Neurology Consultants
RECRUITING

Round Rock, Texas, 78681, United States
Centro Parkinson e Parkinsonismi
RECRUITING

Milan, Lombardy, 20126, Italy
Centro de Pesquisas Clinicas
RECRUITING

São Paulo, São Paulo, 01228-200, Brazil
Changhua Christian Hospital
RECRUITING

Changhua County, 500, Taiwan
Charing Cross Hospital
RECRUITING

London, W6 8RF, United Kingdom
Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin
RECRUITING

Berlin, 12203, Germany
Charter Research - Winter Park/Orlando
RECRUITING

Orlando, Florida, 32803, United States
China Medical University Hospital
RECRUITING

North Dist., 40447, Taiwan
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Lou Ruvo
RECRUITING

Las Vegas, Nevada, 89106, United States
Dent Neurological Institute
RECRUITING

Amherst, New York, 14226, United States
Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP*X*
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
RECRUITING

Xi'an, 710061, China
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, 350001, China
Georgetown University
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, 510115, China
Hawaii Pacific Neuroscience
RECRUITING

Honolulu, Hawaii, 96817, United States
Heinrich-Heine Universitätsklinik Düsseldorf
RECRUITING

Düsseldorf, 40225, Germany
Hospices Civils de Lyon - Hôpital Pierre Wertheimer
RECRUITING

Bron, Rhône, 69003, France
Hospital Clinic Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Dr. Nélio Mendonça;Serviço de Neurologia
RECRUITING

Funchal, 9004-514, Portugal
Hospital General De Catalunya
RECRUITING

Sant Cugat del Vallès, Barcelona, 08195, Spain
Hospital General Universitario de Elche
RECRUITING

Elche, Alicante, 03203, Spain
Hospital General de Mexico
RECRUITING

Mexico City, Mexico CITY (federal District), 6726, Mexico
Hospital Pedro Hispano
RECRUITING

Matosinhos Municipality, 4464-513, Portugal
Hospital Quiron de Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Regional Universitario de Malaga ? Hospital General
RECRUITING

Málaga, 29009, Spain
Hospital Ruber Juan Bravo
RECRUITING

Madrid, 28006, Spain
Hospital Univ 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Fundación Alcorcón
RECRUITING

Alcorcón, Madrid, 28922, Spain
Hospital Universitario de La Princesa
RECRUITING

Madrid, 28006, Spain
Hospital da Luz Coimbra
RECRUITING

Coimbra, 3020-479, Portugal
Hospital de Braga
RECRUITING

Braga, 4710-243, Portugal
Huashan Hospital, Fudan University
RECRUITING

Shanghai, 200040, China
IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, Lombardy, 20133, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
IRCCS San Raffaele;Clinical Trial Center
RECRUITING

Rome, Lazio, 00166, Italy
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.
RECRUITING

Lublin, 20-410, Poland
Institute for Neurodegenerative Disorders
RECRUITING

New Haven, Connecticut, 06510, United States
Instituto Nacional de Neurologia y Neurocirugia
RECRUITING

Mexico City, Mexico CITY (federal District), 14390, Mexico
Instituto de Neurologia de Curitiba
RECRUITING

Curitiba, Paraná, 81210-310, Brazil
Instytut Zdrowia Dr Boczarska-Jedynak Sp. z o.o. Sp. k.
RECRUITING

Oświęcim, 32-600, Poland
Irccs A.O.U.San Martino Ist
RECRUITING

Genoa, Liguria, 16132, Italy
JEM Research LLC
RECRUITING

Atlantis, Florida, 33462, United States
K2 - Villages
RECRUITING

Lady Lake, Florida, 32159, United States
K2 Medical Research-Maitland
RECRUITING

Maitland, Florida, 32751, United States
Keck School of Medicine of USC
RECRUITING

Los Angeles, California, 900033, United States
Kepler Universitätsklinikum GmbH - Neuromed Campus
RECRUITING

Linz, 4020, Austria
Klinik Ottakring
RECRUITING

Vienna, 1160, Austria
Kliniken Beelitz GmbH
RECRUITING

Beelitz, 14547, Germany
Klinikum rechts der Isar der TU München
RECRUITING

Munich, 81675, Germany
Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K
RECRUITING

Krakow, 31-505, Poland
L2 Ip Instituto de Pesquisas Clinicas Ltda ME
RECRUITING

Brasília, Federal District, 70200-730, Brazil
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mazowiecki Szpital Bródnowski w Warszawie Sp. z o.o.
RECRUITING

Warsaw, 03-242, Poland
Medizinische Universität Graz
RECRUITING

Graz, 8036, Austria
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Montreal Neurological Institute and Hospital
RECRUITING

Montreal, Quebec, H3A 2B4, Canada
NEURO-CARE Sp. z o.o. Sp. Komandytowa
RECRUITING

Katowice, 40-749, Poland
NZOZ Vitamed
RECRUITING

Bydgoszcz, 85-079, Poland
Nanjing Brain Hospital
RECRUITING

Nanjing, 210029, China
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
NeuroCare Center
RECRUITING

Canton, Ohio, 44718, United States
NeuroProtect
RECRUITING

Warsaw, 01-684, Poland
Neurology Center of North Orange County
RECRUITING

Fullerton, California, 92835, United States
Ninewells Hospital, Dundee- Scotland
RECRUITING

Dundee, DD2 1SY, United Kingdom
Nmedis sp. z o.o.
RECRUITING

Rzeszów, 35-232, Poland
Northwestern University Feinberg School Of Medicine
RECRUITING

Chicago, Illinois, 60611, United States
Núcleo de Pesquisa do Rio Grande do Sul
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Ospedale Bellaria
RECRUITING

Bologna, Emilia-Romagna, 40139, Italy
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, OX3 7LE, United Kingdom
Paracelsus Elena Klinik Kassel
RECRUITING

Kassel, 34128, Germany
Parkinson's Disease and Movement Disorders Center of Boca Raton
RECRUITING

Boca Raton, Florida, 33486, United States
Parkinson's Research Centers of America - Long Island
RECRUITING

Commack, New York, 11725, United States
Parkinson?s Research Centers of America ? Palo Alto
RECRUITING

Palo Alto, California, 94301, United States
Perron Institute for Neurological and Translational Science
RECRUITING

Nedlands, Western Australia, 6009, Australia
Plymouth Hospitals NHS Trust - Derriford Hospital
RECRUITING

Plymouth,Devon, PL6 8DH, United Kingdom
Podlaskie Centrum Psychogeriatrii
RECRUITING

Bia?ystok, 15-756, Poland
Policlinica Guipuzcoa
RECRUITING

Donostia / San Sebastian, Guipuzcoa, 20009, Spain
Profound Research LLC at The Neurology Center of Southern California
RECRUITING

Pasadena, California, 91105, United States
Quest Research Institute
RECRUITING

Farmington Hills, Michigan, 48334, United States
Renown Health
RECRUITING

Reno, Nevada, 89502, United States
Rocky Mountain Movement Disorders
RECRUITING

Englewood, Colorado, 80113, United States
Royal Devon and Exeter Hospital (Wonford)
RECRUITING

Exeter, EX2 5DW, United Kingdom
Royal London Hospital
RECRUITING

London, E1 1FR, United Kingdom
Ruijin Hospital Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, 200025, China
Seoul National University Hospital
RECRUITING

Seoul, 110-744, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
RECRUITING

Hangzhou, China
Southern Neurology
RECRUITING

Kogarah, New South Wales, 2217, Australia
Szpital Sw. Wojciecha
RECRUITING

Gda?sk, 80-462, Poland
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Texas Neurology PA
RECRUITING

Dallas, Texas, 75206, United States
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, China
The Alfred Hospital
RECRUITING

Prahan, Victoria, 3181, Australia
The First Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, 510120, China
The First Affiliated Hospital of Sun Yat-sen University
RECRUITING

Guangzhou, 510080, China
The First Affiliated Hospital, Chongqing Medical University
RECRUITING

Chongqing, 400016, China
The First Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The Movement Disorder Clinic of Oklahoma
RECRUITING

Tulsa, Oklahoma, 74136, United States
The Second Affiliated Hospital of Suzhou University
RECRUITING

Suzhou, 215025, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310009, China
Tianjin Medical University General Hospital
RECRUITING

Tianjin, 300052, China
Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5T 2S8, Canada
UCSF Weill Institute for Neurosciences
RECRUITING

San Francisco, California, 94158, United States
Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Universitaettsklinikum Tübingen
RECRUITING

Tübingen, 72076, Germany
Universitatsklinikum Munster
RECRUITING

Münster, 48149, Germany
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States
Università degli studi della Campania Luigi Vanvitelli
RECRUITING

Naples, Campania, 80138, Italy
Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie
RECRUITING

Erlangen, 91054, Germany
Universitätsklinikum Würzburg, Neurologische Klinik und Poliklinik
RECRUITING

Würzburg, 97080, Germany
VCU Health North Hospital
RECRUITING

Richmond, Virginia, 23298, United States
Veracity Neuroscience
RECRUITING

Memphis, Tennessee, 38157, United States
Washington Uni School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medical College
RECRUITING

New York, New York, 10021, United States
West China Hospital of Sichuan University
RECRUITING

Chengdu, 610041, China
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

Conditions

Explore the condition pages connected to this study.

PARKINSON'S DISEASE