The Cleveland Clinic

This study tests two approaches to reduce the overuse of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Researchers will compare rapid diagnostic testing and pharmacist-led de-escalation, alone or together, against usual care. The goal is to …

This early feasibility study tested a 3D holographic guidance system to help surgeons place stent grafts during endovascular aortic repair (EVAR) for abdominal aortic aneurysms. Two patients participated, and the system was used alongside standard X-ray imaging to confirm correct…

This study looked at whether a continuous glucose monitor (CGM) can help track blood sugar levels in 20 people with type 2 diabetes who had a kidney transplant. Participants wore a small sensor that measured glucose around the clock. The goal was to see how often blood sugar stay…

This study tested whether radiofrequency microneedling can safely treat melasma in people with darker skin tones (Fitzpatrick types IV-VI). Ten adults with melasma received the treatment, and doctors measured changes in severity using a standard scoring system. The goal was to se…

This study followed 30 uveitis patients who received a fluocinolone acetonide implant to control eye inflammation. Researchers used advanced imaging (OCT, OCTA, fluorescein angiography) to track changes in inflammation over 12 months. The goal was to see if imaging could better m…

This study compared two different surgical meshes used to repair vaginal vault prolapse, a condition where the top of the vagina drops down. About 100 women having laparoscopic or robotic surgery received either Restorelle® Y mesh or Vertessa® Lite Y mesh. The goal was to see if …

This completed trial tested whether using a continuous vital sign monitor (GE Portrait) with nursing alerts could reduce dangerous changes in oxygen, breathing, and heart rate after major noncardiac surgery. 227 adults were monitored either openly or with the data hidden. The goa…

This study tested a 24-week program that combines WeightWatchers behavioral coaching with prescription GLP-1 medications like Wegovy, Mounjaro, or Zepbound. 180 adults with obesity or weight-related conditions participated. Researchers measured weight loss and related outcomes at…

This study tested whether a simple blood test, called the aldosterone renin ratio (ARR), could help doctors find more cases of primary aldosteronism—a common but often missed cause of high blood pressure that can be cured with surgery or treated with specific medications. Researc…

This study tested whether a wearable thermometer called TempTraq can accurately measure body temperature in adults in the intensive care unit. Researchers compared it to a standard catheter thermometer in 60 patients. If proven accurate, TempTraq could offer a less invasive way t…

This early-phase trial tested whether giving tamsulosin (a drug typically used for prostate issues) before pelvic floor surgery in women could prevent postoperative urinary retention. 100 women undergoing surgery for prolapse, with or without a sling procedure, were enrolled. The…

This completed pilot study looked at whether yoga can help African American adults with high blood pressure manage stress and remember to take their medication. Eight participants attended weekly yoga sessions for 8 weeks. Researchers measured blood pressure, stress levels, and t…

This study tested whether ketorolac, a non-steroidal anti-inflammatory drug (NSAID), works as well as the opioid oxycodone for pain after kidney stone removal. 81 adults who had ureteroscopy and received a ureteral stent took part. For five days after surgery, they recorded their…

This study tested a new approach to help people with cervical spinal cord injury improve arm and hand function. Participants received non-invasive brain stimulation combined with upper limb training over several weeks. The goal was to see if this combination could strengthen musc…

This study tested whether acupuncture can improve heart function and quality of life in people with chronic heart failure. Fourteen patients received 10 acupuncture sessions over 5 weeks, and each person also served as their own control with a no-treatment period. Researchers mea…

This study tested a cooling spray (vapocoolant) to see if it reduces pain when placing an IV in emergency department patients. 300 adults who needed an IV were randomly given either the cooling spray or sterile water before the needle. The main goal was to measure pain scores rig…

This study tested whether injecting a long-lasting numbing medicine (liposomal bupivacaine) near the chest muscles could reduce pain after minimally invasive heart surgery. 210 adults having robot-assisted mitral valve repair took part. The main goal was to see if the nerve block…

This study tested a group program for people with moderate-to-severe sleep apnea who were having trouble using their breathing machine (PAP). The program aimed to help them use the machine more often and for longer each night. Researchers compared the group program to usual care …

This study tested whether Reiki (a light-touch energy therapy) and manual therapy (gentle massage) can improve recovery after open heart surgery. 272 patients were randomly assigned to receive either 20 minutes of these therapies for 3 days after surgery, or usual care with rest.…

This study looked at how eating ultra-processed foods, like hamburgers and fries, changes certain chemicals in your blood and urine compared to eating whole foods. Researchers at the Cleveland Clinic studied 46 healthy adults to track these changes. The goal is to better understa…

This study looked at whether levels of free fatty acids in the blood can help predict how sick a sepsis patient will become. Researchers measured these fats in 74 adults arriving at the emergency department with signs of infection. They then tracked whether patients were admitted…

This study involved 204 adults having major surgery to see what side effects oliceridine, a pain medicine, might cause. Researchers focused on breathing problems like low oxygen levels. The goal was to better understand the drug's safety, not to test a new treatment.

This completed study looked at how a controlled increase in belly pressure (from laparoscopic surgery) affects a hormone called vasopressin and kidney function. Researchers measured pressure, optic nerve size, and urine output in 16 patients having weight-loss surgery. The goal w…

This study compared two heart-mapping systems, RHYTHMIA and CARTO, in 49 adults undergoing a repeat procedure for atrial fibrillation (AF). The goal was to see which system better finds gaps from previous ablations. The study did not test a new treatment but aimed to improve unde…

This study tested a telemedicine approach to deliver cervical cancer screening results to women in El Salvador. Over 1,100 women aged 30-59 took part, and researchers measured how many received their results within 45 days. The goal was to see if using mobile phones could improve…

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This study tested how much heat is lost or gained when healthy volunteers are covered with different warming blankets connected to warming blowers. Twenty people aged 18-40 took part. The goal was to measure heat transfer at 15 body spots and see which blanket-blower combo works …

This study tested a shared decision-making tool called NEST to help pregnant women understand and choose noninvasive prenatal testing (NIPT). Over 600 pregnant women participated, comparing those who used the tool with those who received usual care. The goal was to see if the too…

This study looked at how forced and voluntary exercise change brain signals and thinking skills in 25 people with Parkinson's disease who have a brain pacemaker (DBS). Participants did one session of each exercise type while off their usual medications and DBS. The goal was to fi…

This study checked how well the Dexcom G7, a continuous glucose monitor worn on the skin, matches standard blood sugar tests in 28 adults recovering from heart surgery. Researchers compared readings from the sensor to those from blood draws and fingerstick tests. The goal was to …

This completed trial compared two surgical procedures for removing kidney stones: standard PCNL and mini-PCNL. The study enrolled 18 adults with stones 10-20mm and measured blood loss, complications, and recovery time. The goal was to see if the smaller incision approach offers a…

This completed Phase 4 trial at the Cleveland Clinic enrolled 69 adults with type 2 diabetes or obesity who take GLP-1 medications. Participants were randomly assigned to either continue or pause their GLP-1 drug before an upper endoscopy. The goal was to see if holding the medic…

This study looked at 64 adults hospitalized for acute heart failure to see if a blood marker called cystatin C could detect early kidney problems caused by diuretic treatment. Researchers measured cystatin C levels daily and compared them to standard kidney tests. The goal was to…

This study looked at 70 premature babies in the NICU to see if levels of certain proteins called neurotrophins in their blood could predict later lung and brain development. Researchers measured these proteins, which help nerves grow and lungs work properly, and tracked the babie…

This study tested whether using a dye called indocyanine green along with infrared light helps surgeons see the bile ducts more clearly during gallbladder removal surgery. Over 600 adults having their gallbladder taken out were randomly assigned to either standard white light or …

This study tested how well the Dexcom G6 continuous glucose monitor matches standard blood glucose checks in 40 adults after heart surgery. Participants wore the sensor on their arm for up to 10 days while in the ICU and regular hospital floors. The goal was to see if the device …

This study looked at how choline from eggs or supplements affects levels of TMAO, a compound linked to higher heart disease risk. Researchers gave 86 healthy adults either whole eggs, egg whites, choline supplements, or phosphatidylcholine capsules for 28 days. The goal was to se…

This study used virtual reality to recreate situations that cause freezing of gait in people with Parkinson's disease who have a deep brain stimulator. Fifteen participants walked through a virtual home and grocery store while their brain signals were recorded. The goal was to be…

This study looked at how pain in one knee affects the forces on the other knee during walking. Researchers measured walking patterns in 55 adults with knee osteoarthritis and healthy volunteers. The goal was to understand how the body adjusts movement to protect a painful joint, …

This study looked at whether having a higher body mass index (BMI) and using simple sleep apnea screening questionnaires can predict breathing or sedation-related problems during endoscopy. Researchers enrolled 350 adults with a BMI of 25 or higher who were scheduled for an upper…

This study tested new ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease. Instead of constant stimulation, researchers tried intermittent patterns to see if they could control movement symptoms while causing fewer thinking or memory problems. Sixte…