The Cleveland Clinic
Clinical trials sponsored by The Cleveland Clinic, explained in plain language.
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Clinic aims to boost sleep apnea treatment success
Disease control CompletedThis study tested if a special group clinic could help people with sleep apnea use their prescribed breathing machine more often. 56 adults who were struggling to use their machine regularly were assigned to either attend this group clinic or receive their usual care. The goal wa…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Skin treatment study aims to fade stubborn melasma patches
Disease control CompletedThis study tested whether radiofrequency microneedling can effectively treat melasma, a common skin condition causing dark patches, in people with darker skin tones. Ten participants received three treatments over three months. Researchers measured changes in skin appearance and …
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Smaller incision for kidney stone surgery? study compares two techniques
Disease control CompletedThis study compared two surgical methods for removing kidney stones: the standard procedure (PCNL) and a newer 'mini' version with a smaller incision. Researchers wanted to see if the smaller approach reduced blood loss and improved recovery. The trial involved 18 adults with med…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Study tests which surgical mesh works best for pelvic organ prolapse
Disease control CompletedThis study compared two brands of surgical mesh used to repair vaginal vault prolapse, a condition where the top of the vagina drops down. Over 100 patients were randomly assigned to receive one of the two mesh types during a minimally invasive surgery. Researchers followed patie…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Wireless monitors watch over surgery patients to catch problems early
Disease control CompletedThis study tested whether using a wireless monitoring system that alerts nurses can help catch and reduce dangerous changes in breathing, heart rate, and oxygen levels in patients recovering from major surgery. It involved 227 adults who stayed in the hospital after non-heart sur…
Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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Virtual program tests powerful combo for weight loss
Disease control CompletedThis study tested a 24-week virtual program that combined WeightWatchers behavioral coaching with prescription weight-loss medications (like Wegovy or Zepbound). It aimed to see if this combined approach helped people lose weight and improve related health factors. The study foll…
Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New tech tracks blood sugar to protect transplanted kidneys
Disease control CompletedThis study tested if using a continuous glucose monitor (CGM) could help manage blood sugar in people with type 2 diabetes after they received a kidney transplant. Twenty patients wore the monitor for three months to see if better glucose control could reduce hospital readmission…
Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Zapping the brain to help move paralyzed arms
Disease control CompletedThis study tested whether combining gentle brain stimulation with arm exercises could help people with neck spinal cord injuries regain arm and hand function. Forty-seven participants who had been injured for at least a year received 15 sessions of this combined therapy over seve…
Phase: PHASE1, PHASE2 • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Mar 19, 2026 14:56 UTC
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Brain zap breakthrough? new stimulation pattern aims to protect thinking in Parkinson's patients
Disease control CompletedThis study tested new patterns of deep brain stimulation (DBS) for Parkinson's disease. Researchers wanted to see if using stimulation in short, timed bursts could control movement symptoms as well as the current method of constant stimulation, but with less impact on a patient's…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Mar 10, 2026 12:53 UTC
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Sticker thermometer put to the test in hospital ICU
Diagnosis CompletedThis study tested how well a wearable, sticker-like thermometer (TempTraq) measures body temperature compared to the standard method (a catheter placed near the heart) in intensive care unit (ICU) patients. Researchers enrolled 60 adults with the standard catheter already in plac…
Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Apr 01, 2026 14:42 UTC
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Glowing dye lights the way for safer gallbladder surgery
Diagnosis CompletedThis study tested a new imaging technique to help surgeons see bile ducts more clearly during gallbladder removal surgery. Researchers compared a special fluorescent dye and camera to standard surgical lighting in 677 patients. The goal was to see if the glowing dye made it easie…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Apr 01, 2026 14:41 UTC
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New sensor put to the test in heart surgery recovery
Diagnosis CompletedThis study tested how well the Dexcom G7 continuous glucose monitor works for patients recovering from heart surgery. Researchers compared the monitor's readings against standard blood glucose tests taken during the patients' hospital stay. The goal was to see if the wearable sen…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Mar 31, 2026 12:11 UTC
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Texts vs. trips: can a simple message help more women get vital cancer results?
Diagnosis CompletedThis study tested a new way to get cervical cancer screening results to women in El Salvador. Over 1,100 women were split into two groups: one received their results via text message, while the other followed the standard process of returning to a clinic. The goal was to see if t…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Mar 30, 2026 14:34 UTC
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Sticker sensor could replace frequent finger pricks for hospital patients
Diagnosis CompletedThis study tested whether a wearable, continuous glucose monitor (a small sensor worn on the skin) is as accurate as standard blood tests for patients recovering from heart surgery. Researchers compared the sensor's readings to traditional finger-prick and blood draw results in 4…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Mar 30, 2026 14:33 UTC
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Simple blood test could unlock cure for millions with stubborn high blood pressure
Diagnosis CompletedThis study tested whether using a simple blood test more widely could help find more people with a specific, treatable cause of high blood pressure called Primary Aldosteronism (PA). Researchers checked 53 adults with high blood pressure to see how many cases of PA were being mis…
Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Mar 23, 2026 15:19 UTC
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Ancient needles tested for modern heart woes
Symptom relief CompletedThis small study explored whether acupuncture could help people with chronic heart failure feel better and function better. Researchers tested if adding acupuncture to standard medications could improve heart function, walking distance, and quality of life. The goal was to see if…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Healing touch for the heart: can ancient therapies speed recovery after major surgery?
Symptom relief CompletedThis study tested whether adding Reiki (an energy-based light touch therapy) and gentle manual massage to standard care could help patients recover better after heart surgery. Researchers enrolled 272 adults who had coronary artery bypass or valve surgery. One group received 20-m…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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Chill out: spray tested to take the sting out of IV needles
Symptom relief CompletedThis study tested whether a fast-acting cooling spray could safely reduce the pain adults feel when getting an IV needle placed in the emergency room. Researchers compared the spray to a harmless water spray in 300 stable patients. The goal was to find a quick, needle-free way to…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Mar 30, 2026 14:30 UTC
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Nerve block tested to slash pain after heart surgery
Symptom relief CompletedThis study tested whether a specific type of nerve block, injected near the chest muscles, provides better pain relief than standard pain medications after minimally invasive heart valve repair. It involved 210 adults recovering from this specific surgery. Researchers measured pa…
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Mar 30, 2026 14:28 UTC
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Study tests common painkillers to reduce opioid use after kidney stone procedures
Symptom relief CompletedThis study compared two common pain medications—ketorolac (an NSAID like ibuprofen) and oxycodone (an opioid)—to see which worked better for pain after kidney stone surgery. Eighty-one patients who had a ureteroscopy procedure were randomly assigned to take one of the medications…
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Mar 02, 2026 15:28 UTC
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New pain drug tested for safer breathing after surgery
Symptom relief CompletedThis study looked at whether a newer pain medication called oliceridine causes fewer breathing problems than standard opioids after major surgery. Researchers monitored 111 adults having major operations to see if their breathing was affected while using the medication. Patients …
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Feb 23, 2026 14:55 UTC
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New tool aims to ease tough pregnancy test talks
Knowledge-focused CompletedThis study aimed to improve how doctors and pregnant patients discuss a new prenatal blood test called NIPT. Researchers tested a communication tool to help patients make more informed choices about whether to get the test. The study involved nearly 700 pregnant women, their part…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Apr 01, 2026 21:26 UTC
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Doctors probe hidden link between belly pressure and brain signals during Weight-Loss surgery
Knowledge-focused CompletedThis study aimed to understand how increased pressure in the abdomen during laparoscopic weight-loss surgery affects pressure in the brain and the function of the kidneys. Researchers measured hormone levels, urine output, and brain pressure indicators in 16 patients undergoing s…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:43 UTC
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Doctors test simple drug pause to make common scope safer
Knowledge-focused CompletedThis study looked at whether people should temporarily stop taking certain diabetes and weight loss medications before an upper endoscopy. Researchers wanted to see if pausing these drugs reduces leftover food and liquid in the stomach, which can increase the risk of breathing pr…
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Virtual reality unlocks brain secrets of Parkinson's freezing
Knowledge-focused CompletedThis study used virtual reality to safely trigger freezing of gait episodes in 15 Parkinson's patients who have deep brain stimulators. While patients walked through VR environments, researchers recorded their brain signals to understand what happens in the brain during these fre…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Scientists test which hospital blanket is the coziest
Knowledge-focused CompletedThis study aimed to measure how much heat is lost or gained when people use different full-body warming blankets connected to different warming machines. Researchers tested four warming devices and five blankets on 20 healthy adult volunteers. They measured heat transfer at 15 sp…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Eggs vs. pills: the surprising heart health difference?
Knowledge-focused CompletedThis study aimed to understand if the body processes choline—a nutrient needed for health—differently when it comes from eggs versus from supplements. Researchers wanted to see if these different sources changed the level of a blood compound (TMAO) linked to heart disease risk. T…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Scientists hunt for early warning signs of a silent killer
Knowledge-focused CompletedThis study aimed to understand how a serious inherited disease called hereditary transthyretin amyloidosis begins. Researchers followed 37 people who carry the disease gene but had no symptoms, tracking a specific protein in their blood over five years. The goal was to see if thi…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC
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Simple sleep tests may predict endoscopy dangers
Knowledge-focused CompletedThis study aimed to see if being overweight and having signs of sleep apnea could predict who might have breathing or sedation problems during a routine endoscopy. Researchers followed 350 overweight adults getting an upper endoscopy or colonoscopy, giving them two short sleep qu…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Can a simple blood test predict kidney trouble in heart failure treatment?
Knowledge-focused CompletedThis study aimed to understand if tracking a blood marker called cystatin C could give doctors early warning that a patient's kidneys might be harmed by the fluid-removing (diuretic) drugs used to treat sudden heart failure. Researchers followed 64 hospitalized patients, taking d…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:40 UTC
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Scientists map Brain's exercise response in Parkinson's patients
Knowledge-focused CompletedThis study measured brain activity in 25 Parkinson's patients while they exercised on stationary bikes. Researchers wanted to understand how different types of exercise affect brain function and thinking skills in people with Parkinson's. The goal was to gather information that c…
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:08 UTC
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Doctors use High-Tech scans to watch eye treatment in action
Knowledge-focused CompletedThis study aimed to understand how a steroid implant for uveitis (eye inflammation) affects the eye over time. Researchers followed 30 patients with active uveitis for 12 months after they received the implant. They used special eye scans to measure inflammation and see how it re…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:15 UTC
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Blood test could forecast future breathing and brain problems in preemies
Knowledge-focused CompletedThis study aimed to find a way to predict which premature infants with lung disease might have future breathing or brain development problems. Researchers measured levels of certain proteins, called neurotrophins, in the blood of 70 infants in the intensive care unit. The goal wa…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 17, 2026 13:08 UTC
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Scientists map how knee pain changes your walk
Knowledge-focused CompletedThis study aimed to understand how pain in one knee affects the forces on the other knee and the rest of the body during walking. Researchers compared 30 adults with painful knee arthritis to 25 healthy adults by having them walk on a treadmill under different conditions. People …
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Mar 02, 2026 15:24 UTC