The Cleveland Clinic

This study tests whether a ketone ester supplement, taken three times a day for 12 weeks, can improve heart function in people with heart failure. Fifty participants will be randomly assigned to receive the supplement or a placebo. Heart function will be measured using cardiac MR…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This pilot study tests a new rinse device (SwishKit) plus standard oral care against standard care alone in 21 intubated ICU patients. The goal is to see if the device reduces harmful bacteria in the mouth and throat, which could lower the risk of lung infections. The study is sm…

This study tests a procedure for people with early-stage osteonecrosis (bone death) of the hip. Doctors drill into the hip bone, inject a concentrated sample of the patient's own bone marrow, and add a special bone graft material called Genex. The goal is to see if this helps bon…

This study aimed to test whether injecting stem cells from a donor's bone marrow into the pouch (a surgically created internal reservoir) could safely treat pouchitis that hadn't improved with antibiotics or other drugs. The trial was planned for 12 adults aged 18-75 in the U.S.,…

This study aimed to test whether injecting donor stem cells directly into fistulas could safely help heal them in people with Crohn's disease who have an ileal pouch. The trial was withdrawn before any participants were enrolled, so no results are available. The approach was expe…

This study tests whether adding a device that delivers mild electrical pulses (intermittent electrical stimulation) to standard care (turning patients every two hours) helps heal stage 1 or 2 bedsores on the lower back or tailbone. About 1,100 hospitalized adults will be randomly…

This study tests whether giving oral salt tablets alongside standard IV diuretics helps hospitalized heart failure patients lose more fluid and maintain better kidney function. About 67 adults with acute decompensated heart failure will receive either salt or placebo three times …

This study looks at two different ways of ventilating (helping patients breathe) during cardiopulmonary bypass, the machine that takes over for the heart and lungs during surgery. Over 5,500 adults having elective heart surgery will be randomly assigned to receive either low-tida…

This study tests whether combining anti-obesity medications with a structured lifestyle program can help people with obesity lose weight and keep muscle. 150 participants will first take tirzepatide or semaglutide for 9 months, then switch to another oral medication for 12 months…

This study tests whether a uterus transplant from a deceased donor can help 10 women with uterine factor infertility (missing or damaged uterus) give birth. Participants first create embryos through IVF, then receive the transplant, and later attempt pregnancy. The main goal is t…

This study tests whether a 12-week program of exercise and diet counseling can improve insulin sensitivity and heart function in people with pulmonary arterial hypertension (PAH). The 34 participants have stable PAH and are already on standard medications. The goal is to see if l…

This Cleveland Clinic study tests a digital twin system that uses AI and daily sensor data to give personalized coaching on diet, exercise, sleep, and breathing. 150 adults with type 2 diabetes will either use the system or receive usual care for one year. The goal is to see if m…

This study tests whether measuring how the lower back moves and when pain occurs can help doctors tell apart Bertolotti syndrome from other causes of low back pain. Researchers will track 20 people with Bertolotti syndrome and 20 with other back pain as they do simple movements. …

This study tests a new MRI contrast agent called Gadopiclenol to see if it provides clearer images of heart damage in people with atrial fibrillation (AF). Researchers will compare it to standard contrast agents in 50 AF patients. The goal is to improve diagnosis and guide treatm…

This study is checking if a new, low-cost HPV test called ScreenFire works as well as the standard test for finding cervical cancer risk. About 9,100 women aged 30-59 will use a self-collection method. The goal is to see if the test is accurate, reduces follow-up visits, and is c…

This study is testing whether a specific feature on brain MRI scans—called the central vein sign—can improve the accuracy of multiple sclerosis (MS) diagnosis. Currently, up to 1 in 5 people diagnosed with MS are later found not to have the disease, leading to unnecessary and pot…

This study tests whether special air purifiers in operating rooms can reduce serious infections after surgery. Over 66,000 patients having surgery lasting at least one hour are included. The air purifiers are either active or deactivated, and researchers track infections and comp…

This study looks at whether long-term, high-intensity indoor cycling can slow or delay Alzheimer's-related brain changes in healthy older adults (ages 65-80) who carry the APOE ε4 gene, a known risk factor. Participants, who are currently inactive, will use a Peloton bike at home…

This study compares two pain medicines after ACL knee surgery: ketorolac (a non-steroidal anti-inflammatory) and oxycodone (a narcotic). Thirty patients will be randomly assigned to one of the two drugs and tracked for how many narcotic pills they need. The goal is to see if keto…

This study looks at whether a gluten-free diet can improve quality of life for people with Hashimoto's hypothyroidism who still have symptoms like brain fog and fatigue despite standard thyroid medication. About 50 adults with Hashimoto's will follow a gluten-free diet, and resea…

This study tests whether a small device worn behind the ear, which sends mild electrical pulses to nerves, can reduce abdominal pain in adults with gastroparesis-like symptoms (slow stomach emptying). About 140 participants will be randomly assigned to receive either the active d…

This study tests whether an extended-release steroid injection (Zilretta) given during knee meniscus surgery can reduce pain and inflammation in people with osteoarthritis. 150 adults aged 40 and older are enrolled. Researchers will measure knee pain scores and inflammatory marke…

This study looks at how inflammation and oxidation (chemical reactions in the body) might damage the heart and lead to heart failure. Researchers are tracking over 1,200 healthy adults aged 40+ (or 18+ with a family history of heart failure) to see if waste products in blood or u…

This study is building a large gene bank by collecting blood samples and health information from nearly 10,000 people who have had heart catheterization or cardiac CT scans. The goal is to identify genetic and other factors that contribute to coronary artery disease. Participants…

This study uses two advanced MRI techniques to measure muscle health in heart failure patients with and without sarcopenia (age-related muscle loss). Researchers will scan 70 participants to compare muscle composition and energy recovery. The goal is to find better ways to detect…

This study looks at whether video-based coaching can help obstetrics and gynecology residents improve their laparoscopic suturing skills. 28 residents will be randomly assigned to either get standard training or extra video coaching sessions. The goal is to see if coaching leads …

This study aims to improve how asthma is diagnosed and treated by developing new tests and targeted therapies. Researchers will enroll 60 adults with asthma to test a special oil additive and measure lung function and quality of life. The goal is to create better tools for managi…

This study looks at whether removing overactive parathyroid glands (parathyroidectomy) can improve blood sugar control in people who also have type 2 diabetes. Researchers will compare 80 patients who have surgery with those who do not, measuring changes in blood sugar and bone h…

This study looks at whether drinking a beverage with artificial sweeteners (erythritol or xylitol) changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure platelet activity and blood levels of these sweeteners in 50 hea…

This study looks at how the repaired rotator cuff tendon moves after surgery, which may affect recovery. 125 people getting rotator cuff repair will have small markers placed on the tendon during surgery. CT scans and MRIs over 5 years will track tendon position and healing, and …

This study explores whether the characteristics of bone marrow in the upper arm bone can predict how well a torn rotator cuff heals after surgery. Researchers will enroll 50 adults aged 18-75 with full-thickness tears and use MRI and CT scans to measure tendon healing. The goal i…

This early-phase study at the Cleveland Clinic is testing whether combining a type of brain stimulation (paired neurostimulation) with hand training on one side can improve hand movement and dexterity on both sides in people with cervical spinal cord injury. Seventeen participant…

This study looks at how bacteria in your gut break down certain nutrients from food, like carnitine (found in red meat) and choline (found in eggs). Researchers want to see if these gut bacteria produce substances that raise heart disease risk. About 100 healthy adults will provi…

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surger…

This study interviews pregnant patients and their healthcare providers to understand what information and support they need when deciding about prenatal genetic tests. The goal is to create practical resources that help patients make informed choices as testing options keep chang…

This study aimed to see if switching from isoflurane to desflurane during surgery could help adults wake up faster and leave the hospital sooner. It was planned for adults having general anesthesia, but the study was withdrawn before any participants were enrolled. No results are…

This study looks at 219 people who had ACL reconstruction surgery about 10 years ago. Researchers will use MRI scans to check the health of the knee cartilage and compare it to the uninjured knee. The goal is to learn more about how osteoarthritis develops after a knee injury.

This study is testing a new software that measures eye inflammation from standard images taken during routine care. Researchers will enroll 50 people with uveitis, an inflammatory eye disease, to see if the software can detect meaningful changes in inflammation. The goal is to he…

This study uses a special light-based technique called Brillouin microscopy to measure the stiffness of the cornea in people with keratoconus, a condition where the cornea thins and bulges. Researchers will compare measurements before and after treatments like corneal cross-linki…

This study aims to understand how blood sugar levels change in women with Polycystic Ovarian Syndrome (PCOS). Participants will wear a continuous glucose monitor on their arm for certain periods over 6 months, have two blood draws, and complete a questionnaire. The goal is to gat…

This study looks at women with thyroid cancer who get a radioactive iodine whole body scan after thyroid removal. Researchers want to see if the way patients are prepared for the scan—either by stopping thyroid hormone or using a special injection—affects how much iodine is taken…

This study compares virtual (telehealth) care to standard in-person visits for 120 adults recently diagnosed with multiple sclerosis. The goal is to see if virtual care can prevent disability progression just as well, while also being more convenient and cost-effective. Participa…

This study looks at whether substances produced by gut bacteria, called TMAO, can help predict high blood pressure during pregnancy. Researchers will track 200 pregnant women by collecting blood and urine samples throughout their pregnancies. The goal is to find early warning sig…

This pilot study at the Cleveland Clinic is testing whether a simple, non-invasive retinal camera can detect signs of heart failure severity. Researchers will compare eye images from 250 people with and without heart failure to see if blood vessel changes in the retina match dise…

This study looks at how tight the abdominal wall is during hernia repair surgery when a special muscle-cutting step is not used. Researchers will measure tension with a scale and see which patient factors affect it. The goal is to learn how tension relates to recovery and results…

This study is testing whether a special MRI scan can accurately measure the severity of alcoholic liver disease without needing a biopsy. Researchers will scan 20 adults with the condition to look for imaging markers that reflect liver damage. The goal is to develop a non-invasiv…

This study looks at nearly 1,200 people with or at risk for pulmonary hypertension (high blood pressure in the lungs). Researchers use many advanced tests to find new ways to classify the disease and identify biomarkers. The goal is to better understand the disease and improve fu…

This study from the Cleveland Clinic is looking at whether certain migraine medications (CGRP inhibitors) can also improve bladder symptoms like urgency, frequency, and pain. About 200 women with hard-to-treat migraines and bladder issues will be followed for 3 months. Their symp…

This study aims to uncover the genetic roots of atrial fibrillation, a common heart rhythm disorder. Researchers are collecting blood samples and health data from 1,300 adults—some with the condition and some without—to compare their DNA. The goal is to identify genetic variants …