The Cleveland Clinic

This study looks at whether a healthy diet and exercise program can improve symptoms for people with pulmonary arterial hypertension (PAH), a serious lung condition. The idea is that better diet and exercise may help the body use insulin more effectively, which could in turn impr…

This study was designed to see if stem cells from a donor could safely treat fistulas (abnormal tunnels) in people with Crohn's disease who have a surgically created internal pouch. The trial was withdrawn before enrolling any participants, so no results are available. It would h…

This study aimed to test whether stem cells from bone marrow could safely help people with a severe form of pouchitis, a complication after colon surgery for inflammatory bowel disease. The trial was withdrawn before enrolling any participants, so no results are available. The ap…

This study looks at two different ways to use weight-loss medicines over 21 months in 150 adults with obesity. Everyone first gets a strong injectable drug (tirzepatide or semaglutide) plus lifestyle coaching. Then they switch to a daily pill—either phentermine-topiramate or nalt…

This study tests whether a uterus transplant from a deceased donor can help 10 women with uterine factor infertility (missing or damaged uterus) give birth. Participants first undergo IVF to create embryos, then receive the transplant, followed by embryo transfer and pregnancy. A…

This study looks at ways to reduce the overuse of strong antibiotics in adults hospitalized with community-acquired pneumonia. Researchers are testing two approaches: rapid tests to identify the cause of infection faster, and pharmacist-led efforts to stop antibiotics when they a…

This study tests whether a special bone graft substitute (Genex) combined with a hip procedure and bone marrow cells can help people with early-stage osteonecrosis (bone death) of the hip. About 22 adults will receive the treatment and be followed with X-rays and MRIs to see if b…

This pilot study tests a new rinsing device (Swiftsure SwishKit) in 21 ICU patients who are on breathing tubes. The goal is to see if it reduces harmful bacteria in the mouth better than standard oral care alone. The study is small and early-stage, focusing on feasibility and bac…

This study tests a new approach called the Twin Health Precision Treatment system, which creates a digital copy of each patient's body to guide personalized care for type 2 diabetes. 150 adults with diabetes will be randomly assigned to either this digital twin program or standar…

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study tests whether a bedside blood monitoring device (Quantra QPlus) can help doctors decide when to give blood transfusions during complex heart surgery. About 666 adults having high-risk heart surgery will be randomly assigned to either the new device or standard lab test…

This study is testing whether a newer MRI contrast agent called Gadopiclenol can produce clearer images of heart damage in people with atrial fibrillation (AF) compared to standard agents, while using a lower dose. About 50 adults with AF will receive a research MRI scan, and the…

This study tests whether a specific brain MRI feature called the central vein sign can improve the accuracy of multiple sclerosis (MS) diagnosis. About 1 in 5 people diagnosed with MS are later found not to have it, leading to unnecessary and risky treatments. Researchers will sc…

This study checks if a new, low-cost HPV test (ScreenFire) that women can use themselves works as well as the standard test done by a doctor. About 9,100 women aged 30-59 will take part. If successful, it could make cervical cancer screening easier and more affordable in places w…

This study tests whether regular, high-intensity indoor cycling can slow or delay Alzheimer's-related brain changes in healthy older adults (ages 65-80) who carry a genetic risk factor (APOE ε4). Participants will exercise at home on a Peloton bike. The goal is to see if exercise…

This study tests whether a special air cleaning system (ActivePure) in operating rooms can lower the risk of serious surgical site infections, complications, and death within 30 days after surgery. Over 66,000 adults having surgery lasting at least one hour are included. The goal…

This study tests whether adding gentle electrical stimulation to standard wound care helps heal stage 1 or 2 bedsores on the lower back or tailbone. About 1,100 hospitalized adults will be randomly assigned to receive either standard care alone or standard care plus a special ele…

This study looks at whether a gluten-free diet can improve quality of life for people with Hashimoto's hypothyroidism who still have symptoms like brain fog and fatigue despite taking thyroid medication. About 50 adults with Hashimoto's and low quality of life will follow a glute…

This study looks at whether a dietary supplement called ketone ester can improve heart function in people with heart failure. About 50 participants will receive either the supplement or a placebo for 12 weeks. Heart function is measured with MRI scans before and after the treatme…

This study tests whether giving oral salt tablets along with standard IV diuretics helps hospitalized heart failure patients get rid of excess fluid more effectively while protecting kidney function. About 67 adults with acute heart failure and fluid overload will receive either …

This study tests whether a steroid injection (triamcinolone) given right after knee surgery can reduce pain and inflammation in people with osteoarthritis. 150 adults aged 40 and older who are having arthroscopic knee surgery will receive either the injection or a placebo. The go…

This study tests a device called IB-Stim, which uses mild electrical pulses to calm nerves in the ear, to see if it reduces abdominal pain in adults with gastroparesis-like symptoms (slow stomach emptying). About 140 participants will receive either real or sham (fake) stimulatio…

This study looks at whether video-based coaching can help Ob/Gyn residents get better at laparoscopic suturing (a key surgical skill). 28 residents will be split into two groups: one gets standard training, the other also gets three video coaching sessions. The goal is to see if …

This study looks at how tight the abdominal wall is during hernia repair surgery. Researchers will measure tension using a special scale and see which patient factors affect it. The goal is to learn more about tension and how it relates to recovery. About 50 adults with midline h…

This study aims to understand how blood sugar levels change in women with Polycystic Ovarian Syndrome (PCOS) over 6 months. Participants wear a small sensor on their arm that measures sugar levels continuously, have two blood draws, and fill out a questionnaire. The study does no…

This study looks at whether drinking a beverage with artificial sweeteners (erythritol or xylitol) changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure blood and urine levels of these sweeteners and test platelet fun…

This study examines whether removing overactive parathyroid glands (parathyroidectomy) improves blood sugar control in people with both type 2 diabetes and primary hyperparathyroidism. Researchers will also track changes in bone health. About 80 adults are being observed—some hav…

This study looks at how the repaired rotator cuff tendon moves away from the bone over time, even if it stays connected. Researchers will follow 125 people for up to 5 years after surgery using special X-rays and MRI scans. The goal is to see if this movement affects strength, pa…

This study uses advanced MRI scans to examine knee cartilage health in 219 people who had ACL reconstruction surgery 10 years ago. Researchers want to understand how post-traumatic osteoarthritis develops after such injuries. Participants are from a larger ongoing study and will …

This study tests whether a simple, non-invasive eye scan can help doctors assess heart failure severity. Researchers will look at blood vessels in the retina and compare them to standard heart failure tests. The goal is to see if retinal imaging can provide useful information abo…

This study tests whether virtual telehealth visits work as well as in-person clinic visits for people with multiple sclerosis (MS). About 120 adults with a recent MS diagnosis will be randomly assigned to either virtual or in-person care for 24 months. Researchers will track disa…

This study aims to uncover the genetic factors behind atrial fibrillation, a common heart rhythm disorder. Researchers will collect blood samples and health data from 1,300 adults—both those with and without the condition—to build a gene bank. The goal is to better understand why…

This study looks at how bacteria in the gut break down carnitine (found in red meat) and choline (found in eggs), and whether these processes affect heart disease risk. About 100 healthy adults will provide blood samples to measure these substances. The goal is to understand the …

This study looks at how two migraine treatments (CGRP inhibitors and Botox injections) change bladder symptoms like urgency, frequency, and pain in women. Researchers will compare symptoms before and after 3 months of treatment using questionnaires. The goal is to understand if t…

This study planned to compare two common anesthetics, desflurane and isoflurane, to see which one helps adults wake up faster and leave the hospital sooner after surgery. It was designed for adults having general anesthesia at the Cleveland Clinic. However, the study was withdraw…

This study looks at whether a special MRI scan can measure how severe alcoholic liver disease is without needing a biopsy. Researchers will scan 20 adults with the disease to find imaging markers that show liver damage. The goal is to create a non-invasive tool to track disease p…

This study looks at how the way thyroid cancer patients prepare for a radioactive iodine scan affects breast tissue. Researchers want to see if the method of preparation changes prolactin levels and breast uptake of the scan. The study includes 39 women with thyroid cancer who ar…

This study looks at how inflammation and oxidation damage cells and whether waste products from these processes in blood or urine can signal heart disease risk. Researchers will follow over 1,200 healthy adults aged 40+ (or 18+ with family history) for years, tracking heart-relat…

This study uses a special light-based technique called Brillouin microscopy to measure how stiff or weak the cornea is in people with keratoconus, a condition that thins and bulges the cornea. Researchers will also look at how the cornea changes after treatments like cross-linkin…

This study explores whether the characteristics of bone marrow in the upper arm bone are linked to how well torn rotator cuff tendons heal after surgery. Researchers will enroll 50 adults aged 18-75 with full-thickness tears to measure healing using MRI and CT scans. The goal is …

This study looks at how different breathing machine settings during heart surgery affect patients' recovery. Over 5,500 adults having planned heart surgery with a heart-lung machine are included. The goal is to see if using low air volume and avoiding too much oxygen can lower th…

This study tests whether combining a non-invasive brain stimulation technique called paired neurostimulation with hand exercises can help people with cervical spinal cord injury improve hand and arm movement. Seventeen participants with injuries between C4 and C8 will undergo tra…

This study explores whether gut bacteria and diet play a role in high blood pressure during pregnancy. Researchers will measure a substance called TMAO in blood and urine from 200 pregnant women across all three trimesters. The goal is to find early markers that could predict who…

This study involves 40 adults with lower back pain—half have Bertolotti syndrome, half have other causes. Researchers use wearable sensors to measure how the spine moves and track pain in real time during simple tasks. The goal is to find unique movement patterns that can help do…

This study looks at people with different types of heart and lung disease to better understand pulmonary hypertension (high blood pressure in the lungs). Researchers use advanced tests and genetic analysis to find new ways to classify the disease and identify biomarkers. The goal…

This study collects blood samples and medical information from nearly 10,000 people undergoing heart tests at Cleveland Clinic and other hospitals. The goal is to create a large gene bank that researchers can use to better understand what causes coronary artery disease. Participa…

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications involving the heart, kidneys, and brain. About 80 adults aged 45 and older who take blood pressure medication and are having major non-cardiac s…

This study tests a new imaging software that measures eye inflammation in people with uveitis, a condition that causes swelling inside the eye. Researchers want to see if this tool can help doctors decide when to start or change treatment. About 50 patients with active or recent …

This study interviews pregnant patients and their doctors to understand what information and support they need when deciding about prenatal genetic tests. The goal is to create better resources and strategies to help patients make informed choices. About 78 participants will take…