New strategy aims to cut unnecessary antibiotics in pneumonia care

NCT ID NCT05568654

Completed Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tests two approaches to reduce the overuse of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Researchers will compare rapid diagnostic testing and pharmacist-led de-escalation, alone or together, against usual care. The goal is to give the right antibiotics only when needed, lowering side effects and drug resistance. About 12,500 patients across multiple hospitals will take part.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIMICROBIAL STEWARDSHIP COMMUNITY-ACQUIRED PNEUMONIA POINT OF CARE TESTING

Contacts and locations

Locations

Akron General Hospital

Akron, Ohio, 44307, United States
Avon Hospital

Avon, Ohio, 44011, United States
Cleveland Clinic Main Campus

Cleveland, Ohio, 44195, United States
Euclid Hospital

Euclid, Ohio, 44119, United States
Fairview Hospital

Fairview Park, Ohio, 44111, United States
Hillcrest Hospital

Mayfield Heights, Ohio, 44124, United States
Indian River Hospital

Vero Beach, Florida, 32960, United States
Lutheran Hospital

Cleveland, Ohio, 44113, United States
Marymount Hospital

Garfield Heights, Ohio, 44125, United States
Medina Hospital

Medina, Ohio, 44256, United States
South Pointe Hospital

Warrensville Heights, Ohio, 44122, United States
Weston Hospital/Cleveland Clinic Florida

Weston, Florida, 33331, United States

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