New strategy aims to cut unnecessary antibiotics in pneumonia care

NCT ID NCT05568654

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests two approaches to reduce the overuse of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Researchers will compare rapid diagnostic testing and pharmacist-led de-escalation, alone or together, against usual care. The goal is to give the right antibiotics only when needed, lowering side effects and drug resistance. About 12,500 patients across multiple hospitals will take part.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Akron General Hospital

    Akron, Ohio, 44307, United States

  • Avon Hospital

    Avon, Ohio, 44011, United States

  • Cleveland Clinic Main Campus

    Cleveland, Ohio, 44195, United States

  • Euclid Hospital

    Euclid, Ohio, 44119, United States

  • Fairview Hospital

    Fairview Park, Ohio, 44111, United States

  • Hillcrest Hospital

    Mayfield Heights, Ohio, 44124, United States

  • Indian River Hospital

    Vero Beach, Florida, 32960, United States

  • Lutheran Hospital

    Cleveland, Ohio, 44113, United States

  • Marymount Hospital

    Garfield Heights, Ohio, 44125, United States

  • Medina Hospital

    Medina, Ohio, 44256, United States

  • South Pointe Hospital

    Warrensville Heights, Ohio, 44122, United States

  • Weston Hospital/Cleveland Clinic Florida

    Weston, Florida, 33331, United States