New study tests best way to lose weight without losing muscle
NCT ID NCT06854614
First seen Jan 11, 2026 · Last updated May 14, 2026 · Updated 16 times
Summary
This study looks at two different ways to use weight-loss medicines over 21 months in 150 adults with obesity. Everyone first gets a strong injectable drug (tirzepatide or semaglutide) plus lifestyle coaching. Then they switch to a daily pill—either phentermine-topiramate or naltrexone-bupropion versus orlistat—to see which better maintains weight loss and preserves muscle. The goal is to find a safe, effective long-term plan for managing obesity.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
Conditions
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