New combo treatment aims to help patients with liver disease and obesity

NCT ID NCT07058155

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a two-step procedure can help people with advanced liver disease and severe obesity. First, a TIPS procedure lowers pressure in the liver veins. Then, sleeve gastrectomy surgery helps with weight loss. The study compares this approach to standard medical care. Researchers will track quality of life and weight loss over 6 months in 70 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

TIPS procedure and sleeve gastrectomy surgery

What this could lead to

If successful, this could offer a new, safe treatment path for people with both advanced liver disease and severe obesity who currently have few options.

What could go wrong

This is a small, early-phase trial with only 70 participants, so results may not apply to everyone. Both procedures carry risks like bleeding, infection, or liver complications.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver morbid obesity portal hypertension Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Cleveland Clinic Main Campus

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Email: •••••@•••••

    Contact