New combo treatment aims to help patients with liver disease and obesity

NCT ID NCT07058155

Recruiting now Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a two-step procedure can help people with advanced liver disease and severe obesity. First, a TIPS procedure lowers pressure in the liver veins. Then, sleeve gastrectomy surgery helps with weight loss. The study compares this approach to standard medical care. Researchers will track quality of life and weight loss over 6 months in 70 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TIPS procedure and sleeve gastrectomy surgery
What this could lead to: If successful, this could offer a new, safe treatment path for people with both advanced liver disease and severe obesity who currently have few options.
What could go wrong: This is a small, early-phase trial with only 70 participants, so results may not apply to everyone. Both procedures carry risks like bleeding, infection, or liver complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver morbid obesity portal hypertension Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER CIRRHOSES PORTAL HYPERTENSION RELATED TO CIRRHOSIS SEVERE OBESITY TIPS

Contacts and locations

Locations

Cleveland Clinic Main Campus
RECRUITING

Cleveland, Ohio, 44195, United States

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