SEVERE OBESITY
Clinical trials for SEVERE OBESITY explained in plain language.
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Can bariatric surgery save hearts? major trial aims to find out
Disease control Recruiting nowThis study is testing whether bariatric surgery (like gastric bypass) can safely reduce the risk of major heart problems—such as heart attacks, strokes, and heart failure—in people with severe obesity and high heart risk. About 700 participants will be randomly assigned to either…
Matched conditions: SEVERE OBESITY
Phase: NA • Sponsor: Population Health Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Surgery + diabetes drug: a new One-Two punch against severe obesity?
Disease control Recruiting nowThis study looks at whether adding a GLP-1 drug (semaglutide) to bariatric surgery helps people with severe obesity lose more weight and keep it off. About 200 adults aged 18-60 with a BMI of 35 or higher and related health issues will be followed for a year. The goal is to see i…
Matched conditions: SEVERE OBESITY
Phase: PHASE1, PHASE2 • Sponsor: China-Japan Friendship Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New combo treatment aims to help patients with liver disease and obesity
Disease control Recruiting nowThis study tests whether a two-step procedure can help people with advanced liver disease and severe obesity. First, a TIPS procedure lowers pressure in the liver veins. Then, sleeve gastrectomy surgery helps with weight loss. The study compares this approach to standard medical …
Matched conditions: SEVERE OBESITY
Phase: PHASE4 • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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New surgery may offer better reflux control for obese patients
Disease control Recruiting nowThis study compares two surgical options for people with severe obesity and acid reflux (GERD). Half of the 560 participants will get a newer procedure called Nissen-Sleeve Gastrectomy, which combines stomach reduction with a reflux barrier; the other half will get the standard R…
Matched conditions: SEVERE OBESITY
Phase: NA • Sponsor: Jagiellonian University • Aim: Disease control
Last updated Jun 26, 2026 13:41 UTC
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New study to test if fancy scanners beat the scale after obesity surgery
Knowledge-focused Recruiting nowThis study will enroll 20 adults with severe obesity who are scheduled for weight-loss surgery. Researchers want to see if advanced tools like MRI and 3D body scans give a clearer picture of health changes than just measuring weight or waist size. Participants will be followed fo…
Matched conditions: SEVERE OBESITY
Sponsor: Pennington Biomedical Research Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Which surgery is better for mental health? new study compares sleeve vs. bypass
Knowledge-focused Recruiting nowThis study looks at 100 adults with severe obesity to see if the type of weight-loss surgery—sleeve gastrectomy or gastric bypass—changes binge eating, depression, and anxiety differently. Participants fill out questionnaires before surgery and for 12 months after. The goal is to…
Matched conditions: SEVERE OBESITY
Phase: NA • Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Obesity and diabetes: scientists hunt for hidden clues in body tissues
Knowledge-focused Recruiting nowThis study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…
Matched conditions: SEVERE OBESITY
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Hair may hold clues to metabolic health after Weight-Loss surgery
Knowledge-focused Recruiting nowThis study looks at how severe obesity and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults—some with severe obesity scheduled for bariatric surgery and some healthy-weight controls—to see if hair chemistry can signal poor metabolic hea…
Matched conditions: SEVERE OBESITY
Sponsor: Singapore General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC