SEVERE OBESITY
Clinical trials for SEVERE OBESITY explained in plain language.
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Could a diabetes drug before bariatric surgery supercharge weight loss?
Disease control Not yet recruitingThis study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…
Matched conditions: SEVERE OBESITY
Sponsor: Mario Musella MD • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Teens to get Weight-Loss drug right after surgery in new trial
Disease control Not yet recruitingThis study tests whether restarting semaglutide (Wegovy) just two weeks after sleeve gastrectomy helps teens with severe obesity lose more weight than surgery alone. About 150 teens aged 12–18 who were already on semaglutide before surgery will be randomly assigned to restart the…
Matched conditions: SEVERE OBESITY
Phase: PHASE3 • Sponsor: Children's Hospital Los Angeles • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Nerve block may ease pain after Weight-Loss surgery
Symptom relief Not yet recruitingThis study tests whether an extra nerve block given during weight-loss surgery can lower pain, nausea, and the need for painkillers in the first three days after surgery. About 200 adults having gastric bypass or sleeve gastrectomy will be randomly assigned to get either standard…
Matched conditions: SEVERE OBESITY
Phase: NA • Sponsor: Endeavor Health • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Study to reveal how Weight-Loss surgery alters your sense of body and eating
Knowledge-focused Not yet recruitingThis study looks at how people with severe obesity perceive internal body signals (like hunger and fullness) before and after bariatric surgery. Researchers will follow 300 adults for two years to see if changes in body awareness and views on illness affect eating behaviors after…
Matched conditions: SEVERE OBESITY
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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New study tests best CPAP settings for obese patients after surgery
Knowledge-focused Not yet recruitingThis study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lun…
Matched conditions: SEVERE OBESITY
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Arm or belly? study seeks best spot for blood clot shot in severe obesity
Knowledge-focused Not yet recruitingThis study looks at whether injecting the blood thinner enoxaparin into the arm or the abdomen works better for preventing blood clots in people with severe obesity (BMI over 40). Researchers will measure drug levels in the blood to see which injection site gives the right amount…
Matched conditions: SEVERE OBESITY
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC