CIRRHOSIS, LIVER

This study looks at whether a type of diabetes medicine called SGLT-2 inhibitors can help control ascites (fluid buildup in the belly) in people with liver cirrhosis and type 2 diabetes. About 40 adults with moderate liver disease will either receive the drug plus standard care, …

This study looks at whether giving antibiotics before an endoscopic procedure is necessary for cirrhosis patients who have had variceal bleeding before. The goal is to see if skipping antibiotics is just as safe and effective. About 226 adults with cirrhosis are taking part.

This study tests whether a structured exercise program before and after liver transplant helps people recover faster and have fewer complications. About 60 adults waiting for a liver transplant will take part. The program includes supervised training before surgery and continued …

This study aimed to see if the antibiotic rifaximin could help people with liver cirrhosis who have a hidden form of brain fog (covert hepatic encephalopathy) and an overgrowth of bacteria in the small intestine. Researchers planned to give 40 patients rifaximin for 8 weeks and t…

This study looks at whether a monitored ketogenic (low-carb, high-fat) diet is safe and effective for weight loss in obese adults with NASH cirrhosis, a serious liver condition. About 40 participants will either follow the ketogenic diet or standard dietary advice for 16 weeks. R…

This study tests whether beta-blockers, a type of blood pressure medication, can reduce the risk of bleeding from small esophageal varices in people with cirrhosis and portal hypertension. About 763 adults with small varices will receive either beta-blockers or a placebo for up t…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care, or…

This study looks at how social and financial challenges—like income, education, and out-of-pocket costs—affect people with cirrhosis and their caregivers. Researchers will ask participants and their caregivers about financial stress and healthcare use. The goal is to better under…

This study follows about 850 adults with severe liver cirrhosis who are scheduled for a TIPS procedure—a shunt placed in the liver to reduce dangerous blood pressure. Researchers will collect real-world data over 5 years to learn how to best use TIPS and manage its side effects, …

This study follows 1,222 adults with liver cirrhosis to understand why some people get worse. Researchers collect health data, images, and samples every 6 months to build models that predict serious complications like fluid buildup or confusion. The goal is to improve early detec…

This study tests whether a personalized, behavior-based program can help people with early signs of liver disease (fatty liver or scarring) manage their condition better than standard care. About 49 adults with risk factors like obesity or diabetes will take part. The goal is to …

This study looks at how often people with type 1 diabetes have nonalcoholic fatty liver disease (NAFLD) and serious liver scarring. Researchers used a painless ultrasound-like test and blood scores to check 533 adults at a diabetes clinic. The goal is to find high-risk patients w…

This study looks at levels of a specific cholesterol-related substance (4beta-hydroxycholesterol) in people with liver cirrhosis. Researchers will compare these levels with those in patients with pneumonia, Crohn's disease, or ulcerative colitis. The goal is to understand how cir…