Could a common diabetes drug help drain dangerous belly fluid?

NCT ID NCT05999773

Ongoing Disease control Sponsor: University of Palermo Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether SGLT2 inhibitors, a type of diabetes medication, can help control ascites (fluid buildup in the belly) in people with liver cirrhosis and type 2 diabetes. Researchers will compare 40 patients who add the drug to their usual treatment against those who stick with standard care alone. The goal is to see if the drug improves fluid control and blood sugar levels without causing serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SGLT2 inhibitors (a class of diabetes drugs)
What this could lead to: If it works, this could point toward a new way to manage ascites (fluid buildup) in people with liver cirrhosis and diabetes, potentially reducing the need for stronger diuretics.
What could go wrong: This is a small observational study (40 people) with no blinding or randomization, so results may not be reliable. SGLT2 inhibitors can cause side effects like urinary infections, dehydration, or kidney issues, especially in people with liver problems.

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Conditions

The condition(s) this trial relates to.

Ascites cirrhosis of liver type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASCITES HEPATIC CIRRHOSIS, LIVER DIABETE TYPE 2

Contacts and locations

Locations

Department of Internal Medicine, University Hospital of Palermo

Palermo, Palermo, 90127, Italy
Internal Medicine Unit, V. Cervello Hospital

Palermo, Italy, 90100, Italy

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