CIRRHOSIS, LIVER

This early study tests whether siplizumab can safely prevent the immune system from attacking a new liver in people with autoimmune hepatitis or primary sclerosing cholangitis. Eight participants will receive two doses of the drug around the time of transplant and be monitored fo…

This study tests whether a leucine-enriched amino acid mixture can reverse muscle loss (sarcopenia) in people with cirrhosis, a common and serious complication. Researchers will give 32 participants either the active mixture or a placebo for 3 months, measuring muscle protein pro…

This study tests whether a special mix of amino acids (HMB-enriched) can help reverse muscle loss in people with cirrhosis. About 24 participants will take either the active supplement or a placebo for 3 months. The goal is to see if the supplement boosts muscle protein productio…

This study tests an experimental drug called PHIN-214 in 74 adults with mild-to-moderate liver cirrhosis (Child-Pugh A or B). The goal is to find a safe dose and see how the body handles the drug. It is an early-phase trial focused on safety, not a cure.

This study tests whether a 12-week online program of exercise, nutrition advice, and behavioral support can improve physical function in adults with cirrhosis who are waiting for a liver transplant. About 177 participants from six Canadian transplant centers will be randomly assi…

This study tests whether rosuvastatin, a widely used cholesterol medication, can safely slow or prevent liver scarring and complications in people with cirrhosis. Researchers will enroll 256 adults with early-stage cirrhosis from causes like fatty liver, alcohol, or hepatitis. Pa…

This study tests a combination of two immunotherapy drugs, tremelimumab and durvalumab, in 32 people with advanced liver cancer who also have moderate cirrhosis (Child-Pugh-B). The main goal is to see if this treatment is safe and tolerable. The study focuses on including underse…

This study tests a home-based program called LiverWatch for people with advanced liver disease (cirrhosis). Participants get a Fitbit, personalized nutrition advice, and weekly education. The goal is to see if this helps improve physical activity, diet, and overall well-being. Ab…

This early-stage trial tests whether giving a mix of healthy gut bacteria (from donors) to people hospitalized with liver disease is safe and tolerable. The study involves 24 adults with liver failure or cirrhosis who have low levels of certain gut chemicals. Researchers will mon…

This study tests a new treatment called RTX001 for people with severe liver cirrhosis that has caused complications. RTX001 uses the patient's own immune cells (macrophages) that are modified in a lab to reduce inflammation and scarring in the liver. The trial will enroll 30 adul…

This study looks at two ways to give fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide fluid choice, while the other follows standard care. The goal is to find which approach is safer and works better. About 50 hospitali…

This study tests a transitional care program for 20 adults with cirrhosis and fluid overload (swelling) after they leave the hospital. Participants get a digital scale, educational materials, weekly check-in calls, and a follow-up appointment. Researchers want to see if this prog…

This study is testing whether a breath test can accurately identify liver cirrhosis in people who may have it. Researchers will give participants a safe food additive and measure how the liver processes it by analyzing breath. The goal is to create a simple, non-invasive risk sco…

This study is testing a special MRI technique (4D flow MRI) to see if it can safely detect dangerous veins in the stomach and esophagus of people with liver cirrhosis. Currently, doctors use a camera tube down the throat (endoscopy) to check for these veins, which can burst and c…

This study tests whether a compound found in green tea, EGCG, can lower the risk of liver cancer in people with liver cirrhosis. About 60 adults with cirrhosis but no prior liver cancer will receive either EGCG or a placebo for a set period. Researchers will measure changes in a …

This study looks at whether increased pressure inside the belly (intra-abdominal hypertension) leads to tiny amounts of stomach fluid entering the lungs (microaspiration) in patients with severe liver disease (cirrhosis) who are on a breathing machine. Researchers will measure be…

This study looks at how 12 weeks of either resistance or endurance exercise affects muscle mass in people with cirrhosis, a liver condition that often leads to muscle loss and ammonia buildup. About 40 adults with cirrhosis will be assigned to cycling, weight training, or standar…

This study looks at how well a tool called the HScore can diagnose hemophagocytic lymphohistiocytosis (HLH) in intensive care patients who also have liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to the ICU to see if the HScore accurate…

This study tests whether using a bedside heart ultrasound (POCUS) to guide fluid and medication decisions improves outcomes for 140 adults with liver cirrhosis and severe sepsis or septic shock. Participants will be randomly assigned to POCUS-guided care or standard guideline-bas…

This study aims to find genetic and immune system clues that may lead to liver cancer in people with fatty liver disease or alcohol-related liver damage. Researchers will study 710 adults, both with and without cirrhosis, to understand early changes that happen before cancer deve…

This study tracks 20 adults with chronic hepatitis delta (a serious liver infection) who are starting a new drug called bulevirtide. Researchers want to see how the drug changes the gut's bacteria and bile acids over 48 weeks, and how those changes relate to inflammation and live…

This study looks at adults with liver cirrhosis who do not have diabetes and are waiting for a liver transplant. Researchers want to find out if simple tests like blood work, activity monitors, and glucose sensors can predict who will develop diabetes after the transplant. Partic…

This study looks at the social and economic challenges faced by people with chronic liver disease, such as trouble paying for food or housing. Researchers will survey 400 patients and their doctors to find out what needs are most common and whether patients want their medical tea…

This study is testing whether a special 3D MRI scan (called 3D-MRE) can accurately measure liver pressure in people with cirrhosis or advanced liver disease. Currently, doctors must insert a thin tube into a neck vein to measure this pressure. If the scan works, it could offer a …