LIVER FIBROSIS

This study tests a drug called hydronidone in people with liver scarring (fibrosis) from chronic hepatitis B. About 1,200 adults will take either hydronidone or a placebo, along with standard antiviral therapy, for up to 5 years. The goal is to see if hydronidone can prevent seri…

This study looks at whether a special ultrasound using a contrast agent called Sonazoid can find early-stage liver cancer better than a regular ultrasound. About 556 adults with liver cirrhosis will be monitored every 4 to 6 months with both methods. The goal is to see if Sonazoi…

This study looks at two different ultrasound machines to see if they can accurately measure liver stiffness and inflammation in people with fatty liver disease. About 95 to 100 adults will take part, including some healthy volunteers. The goal is to find a non-invasive way to tel…

This early-stage study tests hydronidone capsules in 138 healthy Chinese adults to see how the body absorbs, breaks down, and eliminates the drug. It also checks for side effects. The goal is to gather safety and dosing information for future studies on liver fibrosis, not to tre…

This study looks at how a single dose of hydronidone moves through the body in 30 adults with different levels of liver function, from normal to severely impaired. Researchers want to see if liver problems change how the drug is processed, which can help doctors choose the right …

This observational study will measure how often fatty liver and liver scarring occur in 100 adults with type 1 diabetes or LADA in Quebec. Participants will have a single visit for a non-invasive liver scan (FibroScan) and questionnaires. The goal is to find undiagnosed liver pro…

This study looks at the link between high uric acid levels (hyperuricemia) and fatty liver disease in 111 obese adults. Researchers want to see if high uric acid increases the risk of liver scarring (fibrosis). The goal is to find ways to catch liver problems early and possibly u…

This study looks at whether a combination of common blood test results (hs-CRP, triglycerides, and glucose) can help detect liver fibrosis in people with non-alcoholic fatty liver disease (NAFLD). Researchers will observe 96 adults who have NAFLD and compare their blood markers t…