Fibrotic liver disease

This trial tests whether replacing some of the usual diet with navy beans — without changing total calories — is a practical and acceptable way to help manage metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with intermediate-stage liver fibrosis. Forty …

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This study tests a drug called hydronidone in people with liver scarring (fibrosis) from chronic hepatitis B. About 1,200 adults will take either hydronidone or a placebo, along with standard antiviral therapy, for up to 5 years. The goal is to see if hydronidone can prevent seri…

This study tests a new wearable patch-type ultrasound probe that sticks to the skin over the liver to measure stiffness, which can indicate scarring (fibrosis) or cirrhosis. Researchers will compare its accuracy to the standard FibroScan device in 150 adults with chronic liver di…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This study will test whether using a contrast agent called Sonazoid during ultrasound can find early-stage liver cancer better than standard ultrasound alone. About 556 adults with liver cirrhosis will be scanned every 4 to 6 months. The goal is to see if this method catches more…

This pilot study tests whether an AI tool called FibroX can help primary care providers better diagnose advanced liver fibrosis in people with MASLD, a common liver condition. Forty providers will review simulated patient cases, using either standard methods or FibroX, which give…

This phase II trial tests whether a low dose of the cancer drug erlotinib can prevent liver cancer in 60 adults with advanced liver fibrosis or cirrhosis. Participants will take either erlotinib or a placebo daily for a set period. The study will measure changes in a blood protei…

This study looks at whether a structured surveillance program using regular ultrasound and a blood test (alpha-fetoprotein) can detect liver cancer at an earlier, more treatable stage in people at high risk. About 300 adults with liver cirrhosis, chronic hepatitis B, or advanced …

This study tests new MRI techniques to measure blood flow and tissue details in the liver. Researchers will scan 110 people, including healthy volunteers and those with chronic liver disease or fibrosis, to see if these scans can reliably detect liver damage. The goal is to devel…

This study tests whether two different ultrasound machines can accurately measure liver stiffness and inflammation in people with fatty liver disease. About 95 to 100 adults will take part, including healthy liver donors and patients with fatty liver. The goal is to see if these …

This study looks at whether certain blood test results (hs-CRP, triglycerides, and glucose) can help identify liver scarring in people with non-alcoholic fatty liver disease (NAFLD). Researchers will observe 96 adults who have NAFLD and check their blood markers alongside liver s…

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study looks at how a 12-week exercise program (strength and aerobic training twice a week) affects liver fat, inflammation, and scarring in people with metabolic fatty liver disease. It compares results between older adults (70+) and middle-aged adults (40-60), as well as be…

This study looks at how the drug Hydronidone is absorbed, broken down, and removed from the body. Eight healthy Chinese men will take a single dose with a radioactive tracer so researchers can measure the drug in blood, urine, and stool. The goal is to understand the drug's journ…

This early-stage study tests a higher dose of Hydronidone capsules in 138 healthy Chinese adults to see how the drug moves through the body and if it is safe. Participants will receive single or multiple doses, and some will take the drug with food to see if meals affect absorpti…

This study looks at tiny particles in the blood, called extracellular vesicles, to see if they can predict serious liver problems like liver failure or liver cancer. Researchers will collect blood samples from 845 people, including healthy volunteers, diabetes patients, and those…

This study will examine the connection between high uric acid levels (hyperuricemia) and non-alcoholic fatty liver disease (NAFLD) in 111 obese adults. Researchers will use blood tests, ultrasound, and FibroScan to measure uric acid, liver fat, and liver scarring. The goal is to …