Exercise and diet combo takes on fatty liver inflammation

NCT ID NCT06186869

Recruiting now Disease control Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether adding aerobic or high-intensity interval exercise to a low-glycemic Mediterranean diet can lower inflammation better than diet alone. Researchers will enroll 90 adults aged 18-65 with obesity and non-alcoholic fatty liver disease. Participants will be split into three groups: diet only, diet plus moderate aerobic exercise, or diet plus HIIT, and their inflammatory markers will be measured.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mediterranean diet plus either moderate aerobic exercise or high-intensity interval training (HIIT)
What this could lead to: If it works, this could show that combining exercise with a Mediterranean diet is better than diet alone for reducing inflammation and improving health in people with obesity and fatty liver disease.
What could go wrong: This is a small, early-stage study (90 people) and results may not apply to everyone. The benefits seen might be modest, and participants must stick to the programs for results.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatotic liver disease Motor Activity Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAFLD OBESITY

Contacts and locations

Locations

IRCCS De Bellis
RECRUITING

Castellana Grotte, Bari, 70013, Italy

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