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New imaging algorithm could spot hidden cause of chest pain without invasive procedures

NCT ID NCT05634031

Recruiting now Diagnosis Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study aims to create a non-invasive diagnostic algorithm using PET imaging and CT scans to identify microvascular angina in patients who have chest pain and signs of ischemia but no blocked coronary arteries. About 70 participants with symptoms of angina or shortness of breath and non-obstructive coronary artery disease will undergo imaging tests. A small subset may also have an invasive coronary reactivity test for comparison. The goal is to improve diagnosis and management of this often-missed condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PET imaging, coronary CT angiogram, and functional angiography (coronary reactivity test)
What this could lead to
If successful, this could provide a non-invasive way to diagnose microvascular angina, reducing the need for invasive procedures and improving patient care.
What could go wrong
This is a small, early-stage study focused on developing a diagnostic algorithm, not a treatment. The algorithm may not prove accurate enough for widespread use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris intermediate coronary syndrome nonobstructive coronary artery disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGINA NON-OBSTRUCTIVE CORONARY ARTERY DISEASE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mount Sinai Morningside

    RECRUITING

    New York, New York, 10025, United States

    Contact

    Contact

    Contact

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