Which heart drug works best for seniors with multiple ailments? new trial aims to find out

NCT ID NCT05786417

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares two common types of heart medications—beta-blockers and calcium channel blockers—in adults aged 65 and older who have stable angina (chest pain) and at least two other chronic conditions. The goal is to see which drug works better and is easier to tolerate, focusing on quality of life. About 741 participants will be followed to track how well they stick with the medication and how their symptoms change.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: beta-blocker or calcium channel blocker (anti-anginal medications)
What this could lead to: If successful, this could help doctors choose the best medication for older adults with angina and other health problems, improving quality of life and reducing side effects.
What could go wrong: This is a Phase 4 trial comparing existing drugs, so no new treatment is being discovered. Results may not apply to all patients, and individual responses to medications can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris intermediate coronary syndrome myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGINA STABLE ISCHEMIC HEART DISEASE

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Cook County Health
RECRUITING

Chicago, Illinois, 60612, United States
Duke University, School of Medicine
RECRUITING

Durham, North Carolina, 27710, United States
Inova Health Care Services
RECRUITING

Fairfax, Virginia, 22033, United States
Mt. Sinai Health System
RECRUITING

New York, New York, 10029, United States
NYC Health and Hospitals, Harlem Hospital
NOT_YET_RECRUITING

New York, New York, 10037-1802, United States
Nirvana Integrative Medicine
RECRUITING

New York, New York, 10469, United States
Wellstar Research Institute
RECRUITING

Marietta, Georgia, 30060, United States
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06520, United States

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