Simple drug may prevent worrisome fetal heart tracings after epidural

NCT ID NCT05873218

Recruiting now Symptom relief Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a low dose of ephedrine right after an epidural can prevent abnormal fetal heart rate patterns in laboring women. About 100 women requesting labor pain relief will receive either ephedrine or a placebo. The goal is to see if ephedrine reduces the chance of a category II fetal heart tracing, which can be a sign of distress.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ephedrine
What this could lead to: If it works, this could give doctors a simple way to reduce the chance of fetal heart rate changes after epidural, making labor safer and less stressful.
What could go wrong: This is a small, early-phase study with only 100 participants, so results may not apply to all women. Ephedrine can raise blood pressure and heart rate, though the dose used is low and considered safe in obstetrics.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LABOR

Contacts and locations

Locations

Icahn School of Medicine at Mount SInai
RECRUITING

New York, New York, 10029, United States

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