Icahn School Of Medicine At Mount Sinai

This study tests a wrist-worn device called CardiaCare RR2 that stimulates the median nerve to calm irregular heart rhythms after catheter ablation for atrial fibrillation (AF). About 34 adults who have had AF ablation will use the device daily for six months. Half will receive a…

This study tests a new coil device (Kaneka i-ED) in 50 people with wide-necked brain aneurysms. The coil is placed inside the aneurysm to block blood flow and prevent rupture. Researchers will check how well it works, how safe it is, and whether it saves money compared to standar…

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. Instead of operating from the abdomen, surgeons work from the anus upward, which may make it easier to remove the tumor completely. The trial includes 100 adults with e…

This study compares a lower dose of radiation to the standard dose for people with HPV-positive throat cancer. The goal is to see if the lower dose can control the cancer just as well while causing fewer side effects. The trial involves 23 participants with advanced but non-sprea…

This phase II trial is testing whether a lower dose of chemoradiotherapy, given after initial chemotherapy, can effectively treat locally advanced HPV-positive oropharynx cancer while reducing long-term side effects. The study involves 43 participants and tracks how long the canc…

This study tests a program called NeuroResource Facilitation for offenders with brain injury who are about to be released from prison. The program assigns a facilitator to help them access medical care, job training, and other support services. Researchers will track whether this…

This early-phase trial tests a combination of three drugs—iberdomide (a pill), elotuzumab (given by IV), and dexamethasone—in people whose multiple myeloma has returned or stopped responding to prior treatments. The study is small (up to 37 people) and primarily looks at safety a…

This early-phase trial is testing whether an oral herbal formula called E-B-FAHF-2 is safe and tolerable for people with mild-to-moderate Crohn's disease. Only 7 adults will take either the herbal capsule or a placebo for a short time. The goal is to see if it reduces inflammatio…

This early-phase trial tests whether a long-acting nerve block, given during a standard prostate biopsy, can slow the growth of high-risk prostate cancer. The block uses lidocaine and dehydrated alcohol to temporarily stop signals from nerves that may help cancer spread. Only 12 …

This study aims to see if a special MRI scan can accurately detect liver scarring (fibrosis) in people with a liver condition called MASH. Researchers will compare the MRI results with standard tests like ultrasound and blood work in 50 adults. If successful, this could offer a n…

This study compares a new MRI contrast agent, gadopiclenol, to the standard agent, gadoxetate, for imaging liver lesions. Researchers will enroll 23 adults with chronic liver disease or known liver lesions to see if gadopiclenol provides equal or better image quality and lesion v…

This study tests a new, ultra-high-resolution eye scanner that combines two imaging techniques to see the retina in 3D. Researchers will scan 10 healthy adults and 40 people with early or intermediate age-related macular degeneration (AMD). The goal is to improve early detection …

This study compares a shortened MRI scan to the standard ultrasound for detecting liver cancer in 820 adults with liver cirrhosis. Researchers will also check if blood markers can help spot cancer early. The goal is to see if the faster MRI is more accurate and cost-effective for…

This study compares two types of nerve blocks—erector spinae plane (ESP) block and pecto-intercostal fascial (PIF) block—against standard care for controlling pain after heart surgery through the breastbone. About 225 adults aged 18–85 having planned cardiac surgery with a sterno…

This study compares two common labor-inducing drugs, misoprostol and pitocin, in 300 pregnant people with a BMI of 30 or higher. Both drugs are given along with a balloon catheter. The goal is to see which drug leads to a faster delivery and whether it increases the chance of a v…

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific b…

This study tests whether a team of doctors, nurses, social workers, and community health workers providing palliative care at home can improve symptom control and reduce hospital visits for people with advanced dementia. About 153 patients and their family caregivers are taking p…

This study tests a 3-month program that helps World Trade Center responders with asthma take better control of their condition. Participants work with a health coach and an asthma educator to improve medication use and daily management. The goal is to see if this approach improve…

This study explores whether adding guided meditation through a virtual reality headset at the start of voice therapy sessions can help people with voice disorders learn and retain treatment better. Sixty participants will use the TRIPP app on a Meta Quest 2 headset to meditate be…

This study tests a device called MIRA that plays calming audio and visual scenes for patients in the neurosciences ICU. The goal is to see if it is safe, practical, and helpful for their mental and physical recovery. The trial includes 20 patients and 15 staff members, and will m…

This study tests a home-based palliative care program called TIER-PC that adjusts the care team based on a patient's symptoms and ability to function. It includes 60 adults with advanced heart failure or certain cancers living in Manhattan. The program adds more specialists—like …

This study looks at lung problems in over 2,000 World Trade Center workers and volunteers. Researchers will review chest CT scans and breathing tests to find signs of airway disease, lung scarring, and cancer. The goal is to better understand how these conditions develop and how …

This study looks at whether telling women about breast artery calcification (BAC) found on mammograms can encourage them to see a heart doctor and adopt healthier habits. Over 5,400 women participated, with a smaller group randomly receiving a letter that included their BAC resul…

This study tests a digital toolkit called eNav, which includes a website and text message reminders, to help people aged 45–75 get screened for colorectal cancer. The toolkit provides information, motivation, and easy ways to request a screening test. Researchers will compare scr…

This study follows 150 adults aged 65 and older who are receiving radiation therapy for cancer. Researchers will track how well patients complete their treatment, and how their daily function, quality of life, and side effects change over time. Participants fill out surveys and c…

This pilot study looks at whether a nasal spray of oxytocin, sometimes called the 'love hormone,' can improve trust and cooperation in people with borderline personality disorder (BPD). About 40 participants (some with BPD, some healthy) will play a trust game after receiving eit…

This study tests whether methylphenidate (Ritalin) can help weaken memories that link drug cues to cocaine use. Fifty-one adults with cocaine use disorder will receive either methylphenidate or a placebo before recalling drug-related memories, while brain activity and skin respon…

This observational study is looking at over 1,000 adults with asthma to better understand different types of the disease. Researchers will combine real-world medical records with genetic data to see how patients respond to various treatments. The goal is to identify asthma subtyp…