Love hormone nasal spray tested for borderline personality disorder trust issues

NCT ID NCT02225600

Terminated Knowledge-focused Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This pilot study looks at whether a nasal spray of oxytocin, sometimes called the 'love hormone,' can improve trust and cooperation in people with borderline personality disorder (BPD). About 40 participants (some with BPD, some healthy) will play a trust game after receiving either oxytocin or a placebo. The goal is to see if oxytocin changes behavior and brain activity related to social interactions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oxytocin (nasal spray)
What this could lead to: If successful, this could point toward a better understanding of social difficulties in borderline personality disorder and whether oxytocin might help.
What could go wrong: This is a very small, early pilot study that is currently suspended. Results may not apply to real-world settings, and oxytocin's effects on social behavior are still uncertain.

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Conditions

The condition(s) this trial relates to.

borderline personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BORDERLINE PERSONALITY DISORDER

Contacts and locations

Locations

Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States

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