New 'Bottom-Up' surgery could improve rectal cancer outcomes

NCT ID NCT03144765

Ongoing Disease control Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. Instead of operating from the abdomen, surgeons work from the anus upward, which may make it easier to remove the tumor completely. The trial includes 100 adults with early to mid-stage rectal cancer and will measure how well the surgery removes the cancer and how safe it is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transanal total mesorectal excision (taTME) surgery
What this could lead to: If successful, this could offer a safer, more effective surgical option for rectal cancer, potentially reducing complications and improving recovery.
What could go wrong: This is a mid-stage trial with only 100 participants and no comparison group. The technique is complex and may not prove better than standard surgery. Long-term outcomes are still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER SURGERY

Contacts and locations

Locations

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cleveland Clinic Florida

Weston, Florida, 33331, United States
Florida Hospital

Orlando, Florida, 32804, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Kaiser Permanente

Los Angeles, California, 90027, United States
Lankenau Institute

Wynnewood, Pennsylvania, 19096, United States
Mount Sinai Beth Israel

New York, New York, 10003, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Toronto Western Hospital

Toronto, Canada
UC Irvine Hospital

Orange, California, 92868, United States
University of Massachusetts

Worcester, Massachusetts, 01605, United States

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