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A shot of bupivacaine at the surgical site may ease pain after kidney stone surgery — a trial puts it to the test

NCT ID NCT07721571

Symptom relief Sponsor: Hitit University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether injecting a local anesthetic called bupivacaine into the surgical tract can reduce pain after prone percutaneous nephrolithotomy, a common procedure to remove large kidney stones. Sixty adults scheduled for the surgery will be randomly assigned to receive either standard pain medication alone or standard medication plus a bupivacaine injection along the nephrostomy tract at the end of surgery. Researchers will measure pain levels, time to first painkiller request, total opioid use, and recovery speed to see if this simple addition improves pain control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine injected along the nephrostomy tract at the end of surgery
What this could lead to
If effective, this simple, low-cost technique could become a standard way to reduce postoperative pain and opioid use after kidney stone surgery.
What could go wrong
This is a small, early-stage trial. The benefit may be modest, and there is a small risk of local anesthetic side effects or injection-related complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 75 years * Scheduled to undergo elective percutaneous nephrolithotomy in the prone position * Classified as American Society of Anesthesiologists physical status I-III * Able to understand and complete postoperative pain assessments using the Visual Analog Scale * Willing to participate in the study * Provision of written informed consent Exclusion Criteria: * Known allergy or hypersensitivity to bupivacaine or other local anesthetic agents Coagulopathy or clinically significant bleeding disorder Chronic opioid use History of a neurological disorder that may affect pain perception or assessment Neurological or psychiatric condition preventing reliable postoperative pain assessment Active urinary tract infection or sepsis American Society of Anesthesiologists physical status IV or higher Requirement for multiple percutaneous access tracts Bilateral percutaneous nephrolithotomy Requirement for postoperative intensive care Refusal or inability to provide written informed consent

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney calculi Postoperative pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Urology, Hitit University Çorum Erol Olçok Training and Research Hospital, Çorum, Türkiye

    RECRUITING

    Çorum, Çorum, 19040, Turkey (Türkiye)

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