Nephrolithiasis

This study tests a new drug called encaleret against usual treatments for people with a rare genetic condition called autosomal dominant hypocalcemia type 1 (ADH1), which causes low blood calcium and high urine calcium. About 67 participants will receive either encaleret or stand…

This study compares two procedures for removing 1-2 cm kidney stones from the lower part of the kidney. One method uses a thin tube with a camera through the urinary tract, while the other makes a small incision in the back. The goal is to see if the less invasive approach works …

This study planned to test a device called RetroPerc that helps doctors reach and remove large kidney stones. It was designed for adults with kidney stones larger than 10 mm. However, the study was withdrawn before any participants were enrolled, so no results are available.

This study looks at whether losing weight with a special very low-calorie diet (Optifast) can lower oxalate levels in urine for obese adults who have had calcium oxalate kidney stones. Fourteen participants will eat a low-oxalate diet and provide urine samples before and after th…

This study tests whether a daily dose of alpha lipoic acid, an antioxidant supplement, can lower the risk of heart problems in 50 children who are on regular hemodialysis. Participants will either take the supplement or a placebo pill for a period, and researchers will monitor fo…

This study compares two schedules for shockwave lithotripsy (ESWL) to treat kidney stones 8-15 mm. 600 participants will receive two ESWL treatments either in the same week or three weeks apart. Researchers will measure how quickly stones clear, complication rates, and patient qu…

This study looks at whether drinking lemonade (Crystal Light) and taking potassium citrate can improve urine chemistry in people who have had kidney stones and have low citrate or acidic urine. Ten adults will try each combination for a week and collect their urine for 24 hours. …

This study looks back at the medical records of 3000 people who had kidney stones removed using one of two new devices: the CVAC system, a steerable suction catheter, or a special suction tube called FANS. Researchers want to see how well each device clears stones and how safe th…

This study tests whether dapagliflozin, a drug used in adults for diabetes and kidney protection, can reduce protein leakage in the urine of children with chronic kidney disease. Ten children aged 4 to 18 with persistent proteinuria despite standard therapy will take the drug, an…

This study tests a new procedure called VISOR against the standard surgery (PCNL) for removing kidney stones that are 2 to 4 centimeters in size. About 170 adults will be randomly assigned to one of the two surgeries. The main goal is to see how many people are stone-free within …

This study tests a flexible scope with a vacuum attachment to remove large kidney stones (2-3 cm). The goal is to see if it clears stones better and lowers risks compared to standard methods. About 115 adults with normal kidney anatomy will take part.

This study tests whether new software for ultrasound machines can better detect and measure kidney stones compared to standard methods. Researchers will scan 370 adults with known calcium-based kidney stones and compare the results to CT scans and surgical findings. The goal is t…

This study compares two laser methods for breaking up kidney and ureteral stones during surgery. One method uses standard laser pulses, the other uses a newer 'Moses 2.0' pulse mode. Researchers want to see if the newer mode reduces surgery time and improves stone clearance. Abou…

This study tests a device that uses focused ultrasound to gently push kidney stones, helping them pass or relieving pain. Researchers are enrolling 172 people with kidney stones, including those waiting for treatment or recently treated. The goal is to see if the ultrasound can m…

This study compares two drugs—methocarbamol and oxybutynin—to see which works better for pain and discomfort caused by a ureteral stent placed after kidney stone surgery. About 126 adults aged 18 to 80 who have the surgery will take one of the study drugs along with standard pain…

This study tests a new surgical technique for removing large kidney stones (2 cm or bigger). Doctors will use a flexible scope and a special suction tube to break up and remove the stones. The goal is to see if this method is safe and can clear all stones in one procedure. Thirty…

This study tests whether a combination of IV acetaminophen and ketorolac can manage pain during kidney stone shockwave treatment as well as the standard opioid-based regimen. About 266 adults will be randomly assigned to receive either the non-opioid or opioid pain medicines. The…

This study tests whether using a smaller ureteral stent (4.8 Fr instead of 7 Fr) reduces pain and discomfort after kidney stone surgery. About 100 adults who need a stent after surgery will be randomly assigned to one of the two sizes. Patients will report their pain daily until …

This pilot study tests whether daily meditation can improve recovery for children and adults having surgery for kidney stones. Participants will be randomly assigned to either a meditation group or a control group. Those in the meditation group will practice a daily 20-minute gui…

This study compares two types of tubes used during surgery to remove kidney stones. One tube uses suction (vacuum) to help clear stone fragments, while the other is a standard tube. The goal is to see which tube is safer and more effective at removing all stone pieces. About 150 …

This study looks at how vitamin C (ascorbic acid) turns into oxalate, a key component of kidney stones. Researchers will give a special labeled vitamin C to 136 adults—both with and without kidney stones—and measure how much oxalate ends up in their urine. The goal is to understa…

This study looks at how oxalate, a compound found in spinach, affects the energy use of white blood cells in healthy adults. Researchers will give participants a spinach smoothie and measure changes in immune cell function over five hours. The goal is to better understand how die…

This study tests a web-based tool called WellPrept that gives patients clear information before their urology procedures. Researchers want to see if it helps patients feel more confident and understand their condition better, and if it shortens clinic visits. About 300 men and wo…

This study is for people with autosomal dominant hypocalcemia types 1 or 2, rare genetic conditions that cause low blood calcium. Researchers will collect past and future health data from 95 participants to learn how the disease changes over time. The goal is to better understand…

This study looks at how being obese might increase the amount of oxalate your body makes, which can lead to kidney stones. Researchers will give 40 adults (half obese, half not) a special diet and measure their urine oxalate levels. The goal is to understand the link between obes…

This study looks at how obesity changes the way the body handles oxalate, a substance that can form kidney stones. Researchers will give 22 calcium oxalate stone formers a controlled low-oxalate diet and a special tracer to measure oxalate absorption, kidney handling, and natural…

This study was designed to measure how often urine flows backward from the bladder into the ureter after placing a special stent (RELIEF) in people with kidney stones. Researchers planned to use bladder X-rays to check for reflux and track any symptoms. However, the study was wit…

This study from Mayo Clinic looks at whether certain gene variants make people more likely to form calcium oxalate kidney stones. Researchers will compare 2,900 adults with and without a history of kidney stones, analyzing blood samples and lifestyle factors. The goal is to bette…

This observational study aims to develop a model that uses patient information, lab results, and CT scans to accurately identify uric acid urinary stones before treatment. Researchers will enroll 1,650 patients undergoing surgery for urinary stones and compare the model's predict…

This study follows 1,600 people with small kidney stones (4 mm or less) to see how often they pass without help. Participants report symptoms, give blood, and get a follow-up CT scan. The goal is to find out if pain, stone size, or location can predict natural passage within 4 to…

This study aims to identify the bacteria and fungi living in the urinary tract of people with calcium oxalate kidney stones or kidney cancer. Researchers will compare these microbial communities to those in healthy volunteers. The goal is to better understand how these tiny organ…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…