Nephrolithiasis

This study is tracking 238 adults who are already scheduled to have a procedure for kidney stones or an enlarged prostate (BPH) using Boston Scientific devices. The main goal is to see how often serious side effects happen with these tools in real-world use. Researchers will also…

This study tests whether a standardized approach to prescribing opioid pain medication after percutaneous nephrolithotomy (PCNL), a surgery to remove kidney stones, can reduce the number of unused painkillers patients take home. Researchers will compare the usual prescribing habi…

This study tests a new drug called encaleret against usual treatments for people with a rare genetic condition called autosomal dominant hypocalcemia type 1 (ADH1), which causes low blood calcium and high urine calcium. About 67 participants will receive either encaleret or stand…

This trial compares two surgical techniques—percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS)—for removing kidney stones up to 3 cm in people who have only one functioning kidney. The goal is to see which approach clears more stones with fewer complicat…

This study investigates whether the acidity of a person's urine influences how effectively shock wave lithotripsy (ESWL) can break up a single kidney stone smaller than 2 cm. Researchers will measure urine pH before treatment and track whether the stone is completely cleared. If …

This study planned to test a device called RetroPerc that helps doctors reach and remove large kidney stones. It was designed for adults with kidney stones larger than 10 mm. However, the study was withdrawn before any participants were enrolled, so no results are available.

This study looks at whether losing weight with a special very low-calorie diet (Optifast) can lower oxalate levels in urine for obese adults who have had calcium oxalate kidney stones. Fourteen participants will eat a low-oxalate diet and provide urine samples before and after th…

This study compares two schedules for shockwave lithotripsy (ESWL) to treat kidney stones 8-15 mm. 600 participants will receive two ESWL treatments either in the same week or three weeks apart. Researchers will measure how quickly stones clear, complication rates, and patient qu…

This study looks at whether drinking lemonade (Crystal Light) and taking potassium citrate can improve urine chemistry in people who have had kidney stones and have low citrate or acidic urine. Ten adults will try each combination for a week and collect their urine for 24 hours. …

This study looks back at the medical records of 3000 people who had kidney stones removed using one of two new devices: the CVAC system, a steerable suction catheter, or a special suction tube called FANS. Researchers want to see how well each device clears stones and how safe th…

This study tests a new procedure called VISOR against the standard surgery (PCNL) for removing kidney stones that are 2 to 4 centimeters in size. About 170 adults will be randomly assigned to one of the two surgeries. The main goal is to see how many people are stone-free within …

This study tests a flexible scope with a vacuum attachment to remove large kidney stones (2-3 cm). The goal is to see if it clears stones better and lowers risks compared to standard methods. About 115 adults with normal kidney anatomy will take part.

This study tests whether using a smaller ureteral stent (4.8 Fr instead of 7 Fr) reduces pain and discomfort after kidney stone surgery. About 100 adults who need a stent after surgery will be randomly assigned to one of the two sizes. Patients will report their pain daily until …

This study compares two laser methods for breaking up kidney and ureteral stones during surgery. One method uses standard laser pulses, the other uses a newer 'Moses 2.0' pulse mode. Researchers want to see if the newer mode reduces surgery time and improves stone clearance. Abou…

This study tests a device that uses focused ultrasound to gently push kidney stones, helping them pass or relieving pain. Researchers are enrolling 172 people with kidney stones, including those waiting for treatment or recently treated. The goal is to see if the ultrasound can m…

This study compares two drugs—methocarbamol and oxybutynin—to see which works better for pain and discomfort caused by a ureteral stent placed after kidney stone surgery. About 126 adults aged 18 to 80 who have the surgery will take one of the study drugs along with standard pain…

This study tests a new surgical technique for removing large kidney stones (2 cm or bigger). Doctors will use a flexible scope and a special suction tube to break up and remove the stones. The goal is to see if this method is safe and can clear all stones in one procedure. Thirty…

This study tests whether a combination of IV acetaminophen and ketorolac can manage pain during kidney stone shockwave treatment as well as the standard opioid-based regimen. About 266 adults will be randomly assigned to receive either the non-opioid or opioid pain medicines. The…

This pilot study tests whether daily meditation can improve recovery for children and adults having surgery for kidney stones. Participants will be randomly assigned to either a meditation group or a control group. Those in the meditation group will practice a daily 20-minute gui…

This study looks at how a specific gene change (AGXT) affects oxalate production in people who have had calcium oxalate kidney stones. Four participants will eat a low-oxalate diet for five days and then receive an intravenous dose of glycolate. Researchers will measure oxalate l…

This study looks at how vitamin C (ascorbic acid) turns into oxalate, a key component of kidney stones. Researchers will give a special labeled vitamin C to 136 adults—both with and without kidney stones—and measure how much oxalate ends up in their urine. The goal is to understa…

This study looks at how oxalate, a compound found in spinach, affects the energy use of white blood cells in healthy adults. Researchers will give participants a spinach smoothie and measure changes in immune cell function over five hours. The goal is to better understand how die…

This study tests a web-based tool called WellPrept that gives patients clear information before their urology procedures. Researchers want to see if it helps patients feel more confident and understand their condition better, and if it shortens clinic visits. About 300 men and wo…

This study is for people with autosomal dominant hypocalcemia types 1 or 2, rare genetic conditions that cause low blood calcium. Researchers will collect past and future health data from 95 participants to learn how the disease changes over time. The goal is to better understand…

This study looks at how being obese might increase the amount of oxalate your body makes, which can lead to kidney stones. Researchers will give 40 adults (half obese, half not) a special diet and measure their urine oxalate levels. The goal is to understand the link between obes…

This study looks at how obesity changes the way the body handles oxalate, a substance that can form kidney stones. Researchers will give 22 calcium oxalate stone formers a controlled low-oxalate diet and a special tracer to measure oxalate absorption, kidney handling, and natural…

This study was designed to measure how often urine flows backward from the bladder into the ureter after placing a special stent (RELIEF) in people with kidney stones. Researchers planned to use bladder X-rays to check for reflux and track any symptoms. However, the study was wit…

This study from Mayo Clinic looks at whether certain gene variants make people more likely to form calcium oxalate kidney stones. Researchers will compare 2,900 adults with and without a history of kidney stones, analyzing blood samples and lifestyle factors. The goal is to bette…

This observational study aims to develop a model that uses patient information, lab results, and CT scans to accurately identify uric acid urinary stones before treatment. Researchers will enroll 1,650 patients undergoing surgery for urinary stones and compare the model's predict…

This study follows 1,600 people with small kidney stones (4 mm or less) to see how often they pass without help. Participants report symptoms, give blood, and get a follow-up CT scan. The goal is to find out if pain, stone size, or location can predict natural passage within 4 to…

This study aims to identify the bacteria and fungi living in the urinary tract of people with calcium oxalate kidney stones or kidney cancer. Researchers will compare these microbial communities to those in healthy volunteers. The goal is to better understand how these tiny organ…