New drug aims to fix calcium levels in rare genetic disease
NCT ID NCT05680818
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called encaleret against usual treatments for people with a rare genetic condition called autosomal dominant hypocalcemia type 1 (ADH1), which causes low blood calcium and high urine calcium. About 67 participants will receive either encaleret or standard care to see if the drug can safely bring both blood and urine calcium into normal ranges. The goal is to better control the disease, not cure it.
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aarhus University Hospital
Aarhus, 8200, Denmark
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Bone Research & Education Centre
Oakville, Ontario, L6M 1M1, Canada
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CHU Bicetre
Le Kremlin-Bicêtre, 94270, France
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Eramus MC
Rotterdam, 3015 AA, Netherlands
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Fondazione Policlinico Universitario Campus Bio-Medico
Roma, 00128, Italy
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Freeman Hospital
Newcastle upon Tyne, NE7 7DN, United Kingdom
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Hôpital Edouard Herriot - HCL
Lyon, 69003, France
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Indiana University Health University Hospital
Indianapolis, Indiana, 46202, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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NIH
Bethesda, Maryland, 20892, United States
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Norfolk and Norwich University Hospital
Norwich, NR4 7UY, United Kingdom
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Ohio State University Medical Center
Columbus, Ohio, 43203, United States
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Physicians East
Greenville, North Carolina, 27834, United States
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Royal Brisbane and Women's Hospital
Herston, Queensland, 4029, Australia
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Royal North Shore Hospital
Saint Leonards, New South Wales, 2065, Australia
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The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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The University of Tokyo Hospital
Tokyo, 113-8655, Japan
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UCSF Benioff Children's Hospital, Oakland
Oakland, California, 94609, United States
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University Hospital of Pisa
Pisa, 56124, Italy
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Vseobecna fakultni nemocnice v Praze
New Town, 128 08, Czechia
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