Which surgery is safer for a single kidney with stones? a Head-to-Head trial

NCT ID NCT07730892

Ongoing Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial compares two surgical techniques—percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS)—for removing kidney stones up to 3 cm in people who have only one functioning kidney. The goal is to see which approach clears more stones with fewer complications and better preserves kidney function. Adults with a solitary kidney and stones of 3 cm or smaller are eligible to participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: two surgical procedures: percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS)
What this could lead to: If one procedure proves safer or more effective, it could become the preferred option for people with a solitary kidney who need stone removal.
What could go wrong: This is a non-randomized study, so results may be biased. The sample size is modest, and findings may not apply to all stone sizes or patient types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nephrolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL STONES

Contacts and locations

Locations

Urology and Nephrology center , Mansoura University

Al Mansurah, Dakahlia Governorate, 35516, Egypt

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