Could acetaminophen replace opioids for kidney stone pain?

NCT ID NCT07368738

ENROLLING_BY_INVITATION Symptom relief Sponsor: Horizon Health Network Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a combination of IV acetaminophen and ketorolac can manage pain during kidney stone shockwave treatment as well as the standard opioid-based regimen. About 266 adults will be randomly assigned to receive either the non-opioid or opioid pain medicines. The goal is to see if the non-opioid approach provides similar pain control with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetaminophen and ketorolac
What this could lead to: If it works, this could offer a safer, non-opioid option for managing pain during kidney stone procedures.
What could go wrong: This is a small, early-phase trial, so results may not apply to all patients. The non-opioid regimen might not control pain as well as opioids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nephrolithiasis Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTRACORPOREAL SHOCKWAVE LITHOTRIPSY

Contacts and locations

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Locations

St. Joseph's Hospital

Saint John, New Brunswick, E2L 3L6, Canada

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