Obesity's hidden role in kidney stones revealed?

NCT ID NCT04333745

Ongoing Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how obesity changes the way the body handles oxalate, a substance that can form kidney stones. Researchers will give 22 calcium oxalate stone formers a controlled low-oxalate diet and a special tracer to measure oxalate absorption, kidney handling, and natural production. The goal is to understand why obese people are more prone to kidney stones.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Controlled low oxalate diet and carbon-13 oxalate with sucralose
What this could lead to: If successful, this could help explain why obese people form more kidney stones and point toward better dietary advice or treatments to prevent stones.
What could go wrong: This is a small, early-stage observational study with only 22 participants, so results may not apply to everyone. It does not test a new treatment, only measures metabolism.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis nephrolithiasis, calcium oxalate

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY STONE

Contacts and locations

Locations

University of Alabama at Birmingham

Birmingham, Alabama, 35243-3353, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

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