POSTOPERATIVE PAIN

This study tests three different nerve block methods to control pain after shoulder surgery. The goal is to find a technique that works well but has fewer breathing side effects than the standard block. About 120 adults having shoulder arthroscopy will take part. Researchers will…

This study compares 4mg and 8mg of dexamethasone (a steroid) given at the surgical site to reduce pain after dental implant surgery. 138 adults will be randomly assigned to receive one of the two doses or a placebo. Pain will be measured for 6 days after surgery, and the number o…

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain medication) for reducing pain and anxiety after spine surgery. About 105 adults undergoing planned spine surgery will receive one of the two medicines right after the operation.…

This study looks at two different methods to control pain after lower back surgery. One method uses a numbing injection near the spine, while the other uses pain medicine through a vein. Researchers will use a special monitor that checks heart rate to see how well each method wor…

This study tests whether a numbing injection around the cervix (paracervical block) given during vaginal hysterectomy for prolapse can lower pain and reduce the need for strong opioid painkillers after surgery. About 56 participants will receive either the numbing medicine or a p…

This study tests two different numbing techniques to manage pain after heart surgery. 50 adults having open-heart surgery will receive either one nerve block or a combination of two others. The goal is to find which method provides better pain relief and reduces the need for stro…

This study tests whether a special nerve block called the Quadro-Iliac plane block can help people recover better after laparoscopic inguinal hernia surgery. About 70 adults having this surgery will either get the nerve block or a placebo, and their recovery quality will be measu…

This study looks at whether getting women up and moving early after a C-section, along with drinking coffee, can help their bowels work better, reduce pain, and improve mood. About 60 women who had a planned C-section will take part. Researchers will check pain, bowel function, a…

This study tests two different ways to control bleeding and pain during lower back fusion surgery. About 62 adults will be randomly assigned to receive either a large-volume injection of numbing medicine with a vessel-shrinking drug around the spine (PVI) or a smaller injection n…

This study tests whether adding an ultrasound-guided nerve block to standard pain medication can reduce the need for strong opioids and improve pain control after lower back surgery. Fifty adults scheduled for lumbar spine surgery will be randomly assigned to receive either the n…

This study compares two ways to control pain after laparoscopic kidney donation surgery: a nerve block injected into the belly muscles before surgery versus numbing medicine injected into the incision sites at the end of surgery. The goal is to see which method better preserves l…

This study tests whether using virtual reality (VR) can help people recover better and leave the hospital sooner after major abdominal surgery. Sixty adults will either use VR for guided relaxation and mindfulness before and after surgery, or receive standard care. The goal is to…

This study tests if a nerve block given during laparoscopic hernia surgery can lower pain and help patients recover faster. One hundred adults having elective hernia repair will be randomly assigned to receive either the nerve block or standard care. Pain levels and recovery time…

This study tests two different nerve-blocking techniques to see which one works better for pain after mastectomy (breast removal surgery). About 66 women having this surgery will receive one of the two blocks before the operation. Researchers will measure pain levels, how soon pa…

This study tests two types of ultrasound-guided nerve blocks to manage pain after breast cancer surgery. Fifty women having a mastectomy will receive either a newer SPSIP block or a standard ESPB block. The goal is to see which one reduces the need for morphine and improves recov…

This study tests whether tea tree oil mouthwash works as well as chlorhexidine mouthwash for reducing pain, swelling, and jaw stiffness after impacted wisdom tooth extraction. About 54 adults will use one of the two mouthwashes for 7 days after surgery and report their symptoms. …

This study tests whether a rectus sheath block, a type of nerve block, can reduce pain and the need for opioid painkillers after heart surgery. About 75 adults having heart procedures with chest tubes will be randomly assigned to receive the block or not. Researchers will measure…

This study compares two types of nerve blocks for pain after hip surgery. 80 adults aged 50-90 with a broken hip will receive either a sacral erector spinae plane block or a pericapsular nerve group block. The goal is to see which provides better pain relief while preserving leg …

This study looks at whether a special ultrasound-guided nerve block (Quadro-Iliac Plane Block) can help control pain after lumbar spine surgery. About 60 adults having elective back surgery will be observed. The goal is to see if the block lowers pain scores and reduces the need …

This study tests whether an ultrasound-guided nerve block can reduce pain and the need for morphine in people who donate part of their liver. 64 donors will be randomly assigned to get either the nerve block plus standard pain relief, or standard pain relief alone. The goal is to…

This study tests a new pain-relief technique called the Quadro-Iliac Plane Block for people having lower back surgery. The block uses ultrasound to guide numbing medicine into the muscles around the hip bone. Researchers want to see if it reduces the need for strong painkillers a…

This study compares two ways to manage pain after minimally invasive surgery for pectus excavatum (a sunken chest). One method freezes the nerves between the ribs (cryoanalgesia), and the other uses an epidural block. Researchers want to see which approach leads to a shorter hosp…

This study compares two pain-blocking techniques (paravertebral block and erector spinae plane block) in 60 adults undergoing lung surgery. The goal is to see which method better reduces the need for strong painkillers during and after surgery, using a special monitor to guide do…

This study tests if a long-acting pain medicine (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after gallbladder removal. About 86 adults having keyhole surgery will get one of the two medicines as a nerve block. Researchers will measure pain leve…

This study tests whether pranayama breathing exercises can reduce pain and improve comfort for women after a cesarean section. About 100 women who had a planned C-section and feel at least moderate pain will be included. The goal is to see if this simple, drug-free method can be …

This study tests whether using a virtual reality headset and scented necklace can lower pain and anxiety in people recovering from heart or lung surgery. Researchers want to see if this approach is a safe, drug-free alternative to opioids and anxiety medications. About 80 adults …

This study tests two different nerve block techniques to control pain after heart surgery through the breastbone. Fifty adults having planned heart surgery will receive either a combination of two blocks or a single block, all guided by ultrasound. The goal is to see which method…

This study is testing whether a 15-20 minute hypnosis session, given just before abdominal surgery, can lower patients' anxiety and pain. About 48 adults having abdominal surgery will be split into two groups: one gets hypnosis, the other gets standard preparation. Researchers wi…

This study tests whether injecting botulinum toxin (Botox) into the anal muscle one week before hemorrhoid surgery can lower pain after the operation. About 292 adults with severe hemorrhoids will receive either Botox or a placebo injection. Researchers will track pain levels, pa…

This study tests a nerve block called FRONT to see if it helps people recover better after total hip replacement. About 80 adults having hip surgery will either get the block or not, and their recovery quality and pain will be measured. The goal is to find a simple way to improve…

This study tests whether using a pain diary helps patients report pain better after gallbladder removal surgery. About 142 adults will either use a diary or get standard care. The goal is to improve pain assessment without extra drugs.

This study tests whether a gel called RADA-16 can help adults who are having their tonsils removed. The gel is applied during surgery to see if it lowers the chance of bleeding and pain afterward. About 134 people will take part and track their symptoms for 15 days.

This study tests whether giving oxytocin (a natural hormone) through an IV during surgery can lower pain and reduce the need for opioid painkillers after a minimally invasive hysterectomy. About 152 adults aged 18-65 will take part. Half will get oxytocin, half a placebo, and nei…

This study tests whether a specific nerve block, given before surgery, can reduce pain and the need for strong painkillers after minimally invasive heart bypass surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard care or standard care a…

This study tests a new type of nerve block, called a deep rectus sheath block, to see if it reduces pain after laparoscopic gallbladder removal. Sixty adults having this surgery will receive the block, and researchers will measure how much morphine they need in the first 24 hours…

This study compares two types of nerve blocks (EXORA and ESP) to see which one better controls pain after gallbladder removal. The goal is to reduce the need for strong painkillers like opioids, which can cause side effects. About 114 adults having planned gallbladder surgery wil…

This study looks at whether a specific nerve block (external oblique intercostal plane block) can better control pain after liver transplant surgery. Sixty adults getting a liver transplant will be split into two groups: one gets the nerve block plus standard care, the other gets…

This study aims to find the most effective dose of morphine given into the spinal fluid to control pain after a C-section. Researchers will test different doses in 100 healthy women having planned C-sections, adjusting the dose based on each woman's pain relief. The goal is to ac…

This study tests whether a single dose of ketamine given during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic trauma. About 90 participants will be randomly assigned to receive ketamine or standard …

This study tests whether a nasal spray containing two medicines (dexmedetomidine and esketamine) can safely reduce pain in children aged 3-7 after tonsil and adenoid surgery. About 160 children will receive either the spray or a placebo, and their pain levels will be tracked for …

This study tests whether using lidocaine as a spray inside the belly plus through an IV can lower pain after keyhole surgery to remove uterine fibroids. About 100 adults having this surgery will be enrolled. The main goal is to see if fewer people have moderate-to-severe pain in …

This study looks at whether a low dose of ketamine can help reduce the amount of strong painkillers (opioids) needed after a type of aortic repair surgery called TEVAR. About 30 adults having this surgery will receive either ketamine or a placebo, and their pain levels and opioid…

This study tests whether a special nerve block (called a rhomboid intercostal block) can reduce pain and the need for strong painkillers after breast implant surgery. About 40 women will either get the block plus standard anesthesia or standard anesthesia alone. The goal is to se…

This study tests whether giving a nerve block (ESPB) before or during lumbar disc surgery better reduces pain, opioid use, and anesthesia needs. About 60 adults having back surgery will be randomly assigned to one of two timing groups. The goal is to improve pain control, reduce …

This study compares a paravertebral nerve block to usual pain medication in 60 women having a mastectomy with immediate breast reconstruction. The goal is to see if the nerve block reduces pain in the first few days after surgery and may help prevent long-term chronic pain. Parti…

This study looks at which dental medication works better to reduce pain after a root canal retreatment. Sixty adults needing retreatment on a single-root tooth will get either a standard calcium hydroxide paste or a newer bioceramic paste called Bio-C Temp placed inside the tooth…

This study looks at whether giving a nerve block before or after gallbladder surgery reduces pain and the need for strong painkillers. About 96 adults having laparoscopic gallbladder removal will be randomly assigned to receive the block at one of two times. The goal is to find t…

This study looks at whether giving morphine during coronary artery bypass surgery can lower pain levels after the operation. Sixty adults having elective bypass surgery will be randomly assigned to receive either morphine or standard care during the procedure. Researchers will me…

This study looks at whether a special nerve block, called a transversalis fascia plane block, can help control pain and reduce the need for strong painkillers (opioids) after kidney donation surgery. About 50 living kidney donors will take part. Half will get the nerve block plus…

This study tests two different pain-relief methods for people having chest surgery with a camera. One method is a nerve block injection near the ribs, and the other is a spinal injection of morphine. The goal is to see which approach reduces the need for strong painkillers and im…

This study compares two types of pain blocks—sacral erector spinae plane block and dorsal penile nerve block—in 70 boys aged 1-7 years having hypospadias surgery. The goal is to see which block provides better pain relief after the operation. Pain scores and side effects will be …

This study tests two ways of giving anesthesia during brain surgery to see which one leads to less confusion, pain, and nausea after the operation. About 70 adults aged 18-60 having planned brain surgery will take part. One method uses a computer to control the drug dose, while t…

This study tests two different ointments—lignocaine and glyceryl trinitrate (GTN)—to see which one works better for pain relief after hemorrhoid surgery. About 64 adults with severe hemorrhoids will take part. The goal is to find which ointment reduces pain, helps wounds heal fas…

This study tests a program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients reduce opioid use and manage pain. Researchers will compare how many patients successfully wean off opioids…

This study tests whether giving ketamine before laparoscopic sleeve gastrectomy (a type of weight-loss surgery) can reduce pain afterward. Researchers will measure how long it takes for patients to need extra pain medicine. The trial involves 90 adults with a BMI between 35 and 6…

This study tests whether giving a combination of two drugs (lidocaine and dexmedetomidine) during weight-loss surgery can reduce pain, inflammation, and cell stress afterward. About 104 adults having laparoscopic bariatric surgery will be randomly assigned to receive the combo, o…

This study tests a newer nerve block method (EOIB) against a standard combination (TAP+RSB) for controlling pain after laparoscopic stomach cancer surgery. About 100 adults will be randomly assigned to receive one of the two blocks before surgery. The goal is to see if the newer …

This study tests a new nerve block technique (EOIB) against a standard one (ESPB) for pain after laparoscopic stomach cancer surgery. About 184 adults having this surgery will be randomly assigned to receive one of the two blocks. The goal is to see if the new block works just as…

This study tests whether a free mindfulness app can reduce anxiety in 40 adults waiting for planned surgery. Participants will use the app for 4 weeks before their operation. Researchers will measure their anxiety on the day of surgery and track pain and painkiller use afterward.…

This study compares two common pain medicines, fentanyl and remifentanil, given during gallbladder surgery. The goal is to see which one helps the bowel start working again sooner and controls pain better after the operation. About 106 adults having planned laparoscopic gallbladd…

This study compares two types of nerve blocks (DIPB and SIFIB) to see which one works better for pain after hip replacement surgery. 70 adults having hip surgery will be randomly assigned to receive one of the blocks. The goal is to find which block provides better pain relief wi…

This study tests whether injecting a numbing medicine (bupivacaine) into the small cuts and the top of the vagina after laparoscopic hysterectomy can lower pain. About 120 women having this surgery for non-cancer reasons will be randomly assigned to get the injection or not. Pain…

This study tests whether a numbing injection given before heart surgery can lower the amount of opioids (strong painkillers) needed during the operation. The injection targets nerves in the chest wall to block pain from the surgical cut. Researchers will compare opioid use, pain …

This study compares two types of ultrasound-guided nerve blocks to see which provides better pain relief after laparoscopic gallbladder removal. About 70 adults having this surgery will receive one of the two blocks. The goal is to reduce pain and the need for strong painkillers …

This study is testing a single dose of a new pain medicine called tegileridine fumarate to find the best amount for controlling pain after orthopedic surgeries like hip or knee replacement. About 180 adults will receive the drug right after surgery, and researchers will adjust th…

This study tests whether a mild electrical nerve stimulation device (TENS) can help people having gallbladder removal surgery feel less anxious and have less pain afterward. About 80 adults will either get standard care or standard care plus TENS. Researchers will measure pain, a…

This study compares an herbal extract called Aescin (Reparil) to ibuprofen for managing pain, swelling, and jaw stiffness after wisdom tooth removal. About 100 adults aged 18-40 will take either Aescin or ibuprofen for five days after surgery. Researchers will measure pain, facia…

This study compares two methods for managing pain after hip surgery: a fascia iliaca block (an injection near the hip nerves) and a spinal injection of nalbuphine. Researchers want to see which approach delays the need for additional pain medicine. The trial will enroll 120 adult…

This study looks at whether adding a low dose of morphine to the standard spinal anesthesia can better control pain after a planned C-section. About 1,300 women will be randomly assigned to receive either morphine or a placebo (salt water) with their spinal block. All participant…

This study tests three different agents (sodium hypochlorite, chlorhexidine, and cold saline) to stop bleeding during a partial pulpotomy, a dental procedure that removes only the top part of the tooth's nerve. The goal is to see which agent leads to less pain and better nerve su…

This study tests whether a numbing injection (paracervical block) given during vNOTES surgery can lower pain after the procedure. About 58 women having surgery for pelvic organ prolapse will be randomly assigned to receive either the numbing medicine or a placebo. The main goal i…

This study is testing a painkiller called EXPAREL in children under 6 years old who are having heart surgery. The goal is to see how the drug moves through the body and if it is safe compared to a standard painkiller. About 48 children will take part, and the medicine is given as…

This study tests whether combining two ultrasound-guided pain-block techniques (M-TAPA and EXOP) works better than M-TAPA alone for controlling pain after laparoscopic gynecologic surgery. About 86 adults having this surgery will be enrolled. Researchers will measure pain scores,…

This study tests an experimental pain-relief injection called TLC590 in 300 adults having bunionectomy (foot bone surgery). The goal is to see if it reduces pain for 3 days after surgery and helps people avoid stronger opioid painkillers. Participants are randomly assigned to get…

This study aims to find which of two ultrasound-guided nerve-block techniques provides better pain relief for young boys after surgery for an undescended testicle. Researchers will compare the Posterior Quadratus Lumborum Block and the Quadroiliac Plane Block in 70 children aged …

This study looks at whether parents who feel more confident in supporting their child's independence can help reduce their child's pain after minor surgery. Researchers will ask parents of 150 children aged 3 to 18 to fill out questionnaires about their confidence, and then measu…

This study watches 254 adults after elective surgery to see what factors affect how much pain medicine they need in the recovery room. No new treatments are given—just routine care. The goal is to find patterns that help doctors personalize pain management and improve recovery.

This study looks at whether a person's genes change how well the painkiller nalbuphine works after abdominal surgery. Researchers will take blood samples from 263 adults before and after surgery to find gene patterns linked to pain relief. The goal is to make pain treatment safer…

This study aims to find out if a person's genetic makeup influences how much pain they feel after surgery and how much pain medicine they need. Researchers will observe 5,000 adults undergoing planned operations and track their pain levels and recovery for one year. The goal is t…

This study is testing a non-invasive device that measures pain by tracking changes in pupil size after gentle electrical stimulation. Researchers will enroll 100 children and teens aged 6 to 21 who are having surgery or a bone marrow transplant. The goal is to see if this device …

This study looks at why some people have more pain than others after gum graft surgery. About 93 adults will answer surveys and track their pain for two weeks. The goal is to find ways to better manage pain and improve recovery.

This study looks at how patients experience pain monitoring after planned surgery. Researchers want to understand if these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain. About 300 adults having elective general surgery wi…

This study looks at whether the quality of sleep before breast cancer surgery affects pain and inflammation after the operation. Researchers will track 150 women, measuring their sleep quality, blood markers of inflammation, and pain levels. The goal is to see if poor sleepers ha…

This study aims to understand if severe, short-term pain experienced right before emergency surgery increases the risk of developing long-lasting chronic pain after the operation. Researchers will follow 693 adults in France who need urgent orthopedic or abdominal surgery. The go…