New oral painkiller aims to ease recovery after abdominal surgery
NCT ID NCT07709598
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This clinical trial tests an experimental painkiller called HL-1186 for people recovering from abdominal surgery. The study compares HL-1186 to a placebo and to a standard painkiller (oxycodone-acetaminophen) to see how well it controls pain and whether it is safe. Participants are adults aged 18 to 75 who are scheduled for abdominal surgery under general anesthesia and are expected to have moderate to severe pain afterward.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- an experimental painkiller called HL-1186
- What this could lead to
- If effective, HL-1186 could offer a new oral option for managing pain after abdominal surgery, potentially with fewer side effects than current treatments.
- What could go wrong
- This is a mid-stage trial with 330 participants, so results may not apply to everyone. The drug could prove no better than existing painkillers or cause unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
About 330 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
May 2026
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 75 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. 18 years old ≤ age ≤ 75 years old, gender is not limited. 2. 18 kg/m2 ≤ Body Mass Index (BMI) ≤ 30kg/m2. 3. Scheduled to undergo abdominal surgery under general anesthesia, with expected moderate-to-severe postoperative pain intensity. 4. Able to understand the research process and the use of pain scales, and communicate effectively with researchers. 5. After surgery completion, the participant is judged by the investigator to be awake and has a resting NRS score ≥ 4. Exclusion Criteria: 1. Previous surgery on the same site that may affect pain perception at the surgical site. 2. Paresthesia or other pain that may affect postoperative pain evaluation or scale assessment. 3. Neuropsychological disorders that may affect postoperative pain evaluation or scale assessment. 4. Unstable angina, myocardial infarction, severe arrhythmia, NYHA cardiac function class ≥ III, or recurrent asthma attacks, etc., deemed unsuitable for inclusion by the investigator. 5. Poorly controlled hypertension. 6. Sleep apnea syndrome, or the presence of a difficult airway as assessed by the investigator. 7. Known allergy to any component of the investigational drug(s), to perioperative (from induction of anesthesia to completion of surgery) anesthetic/analgesic/antiemetic drugs, or a history of allergy to ≥ 3 substances. 8. Positive for human immunodeficiency virus (HIV) antibody; positive for Treponema pallidum antibody and positive toluidine red unheated serum test (TRUST); positive for hepatitis B surface antigen (HBsAg) with detectable HBV-DNA; or positive for hepatitis C virus (HCV) antibody. 9. Women who are pregnant or breastfeeding (within 1 year after delivery). 10. Participation in another drug or medical device trial within 1 month before screening, or currently participating in another clinical trial receiving investigational intervention. 11. Any other condition considered unsuitable for participation by the investigator.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Postoperative pain are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The study's own enquiry address
This study publishes an address for enquiries. See it below .
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Email: •••••@•••••
Locations
-
Sichuan Provincial People's Hospital
RECRUITINGChengdu, Sichuan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Impact of Cross-Sectional design in Single-File rotary system on apical debris extrusion and postoperative pain following Single-Visit root canal treatment: an in vitro and randomized clinical study
- Comparison of perioperative analgesia nociception index (ANI) between preoperative and postoperative ultrasound-guided transversus abdominis plane Block(TAP block) in laparoscopic cholecystectomy
- Anrikefon injection for postoperative analgesia in thoracoscopic lung surgery: a randomized, Double-Blind, Active-Controlled, Parallel-Group, Single-Center clinical study
- Acupressure may offer drug-free relief after cesarean birth
- Can an extra nerve block cut opioid use after knee replacement?
- Can a double nerve block spare kids with cerebral palsy from Post-Surgery pain?