New oral painkiller aims to ease recovery after orthopedic surgery
NCT ID NCT07699601
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This clinical trial tests an experimental painkiller called HL-1186 for people recovering from orthopedic surgery (bone or joint surgery). The study compares HL-1186 against a placebo (dummy pill) and a standard painkiller (oxycodone-acetaminophen) to see how well it controls pain and whether it is safe. Participants are adults aged 18 to 75 who are scheduled for orthopedic surgery under general anesthesia and are expected to have moderate to severe pain afterward. The main goal is to measure pain relief over the first 48 hours after taking the drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HL-1186
- What this could lead to
- If effective, HL-1186 could offer a new oral painkiller option for people recovering from orthopedic surgery, potentially with fewer side effects than current medications.
- What could go wrong
- This is a mid-stage trial with 330 participants, so results may not apply to everyone. The drug may prove no better than existing painkillers or cause unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Third Xiangya Hospital of Central South University, Changsha, Hunan
RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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