New pain cocktail could replace opioids after hand surgery

NCT ID NCT07644923

Not yet recruiting Symptom relief Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether applying a mix of local anesthetics and blood-clotting drugs directly into surgical wounds during hand surgery can reduce pain and the need for opioid painkillers afterward. Forty adults having elective hand surgery will be randomly assigned to one of four treatment combinations. The goal is to find a safer, non-addictive way to manage post-operative pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine, lidocaine, thrombin, tranexamic acid, aminocaproic acid
What this could lead to: If it works, this could offer a way to manage post-surgery pain without relying on opioids, reducing addiction risk.
What could go wrong: This is a small, early-phase trial with only 40 people, so results may not apply to everyone. The drug mix might not provide better pain relief than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN

Contacts and locations

Locations

NYU Langone Health

New York, New York, 10016, United States

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Other studies related to the condition(s) this trial covers.