Can your sleep length predict the best insomnia cure?

NCT ID NCT06281756

Recruiting now Symptom relief Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 600 adults with chronic insomnia to see if those who sleep less than 6 hours respond differently to treatment than those who sleep longer. Participants first receive 8 weeks of cognitive behavioral therapy (CBT-I). If that doesn't help, they are randomly assigned to take either the medication trazodone or a placebo for another 8 weeks. The goal is to improve sleep and lower blood pressure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trazodone
What this could lead to: If successful, this could help doctors choose the best insomnia treatment for each patient, potentially reducing high blood pressure risks.
What could go wrong: This is an early-phase study, so results are uncertain. The treatments may not work differently for the two insomnia types, and benefits may not be large.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder insomnia sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD PRESSURE BLOOD PRESSURE, HIGH INSOMNIA INSOMNIA CHRONIC INSOMNIA, PRIMARY

Contacts and locations

Locations

National Jewish Health
RECRUITING

Denver, Colorado, 80206-2761, United States
Penn State University
RECRUITING

Hershey, Pennsylvania, 17033, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213-3203, United States
Université Laval
RECRUITING

Québec, Quebec, G1V 0A6, Canada

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