Insomnia

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will receive either CBT-I or a patient education program. The main goal is to see if improv…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This study tests a new 'intelligent duvet' called Easy Sleep Monitoring (ESM) that uses built-in sensors to detect movement and estimate sleep. Researchers will compare its accuracy to standard sleep lab tests (video-polysomnography) in 50 people, including those with sleep disor…

This study tests whether a digital sleep program (CBT-I) can prevent depression in pregnant people with insomnia. 456 participants will either use the CBT-I app or receive standard sleep hygiene education. Researchers will track who develops depression through one year after birt…

Researchers are testing whether a daily oral supplement regimen improves skin, hair, sleep, energy, cognition and sexual wellbeing in healthy adults aged 35 to 65. Participants take either the active supplement or a placebo for 12 weeks. The study measures skin elasticity, firmne…

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This study tests a 6-week mindfulness-based program designed to improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 women and track changes in sleep quality, stress levels, and how acceptable and feasible the program is. The goal is to see if…

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…

This study tests whether a drug-free vibrotactile patch, worn during sleep after night shifts, can improve sleep recovery in doctors. Twenty doctors who work regular night shifts will wear either the active patch or a sham patch across 3-4 post-shift sleep episodes. Researchers w…

This trial tests whether cognitive behavioral therapy for insomnia (CBT-I) can reduce cancer-related fatigue in breast cancer patients who also have chronic insomnia. Participants receive different doses of CBT-I, which focuses on changing sleep habits and thoughts. The study aim…

This study looks at whether adding cognitive behavioral therapy for insomnia (CBT-I) to standard knee osteoarthritis care (education and exercise) helps reduce pain and improve function. About 128 adults aged 45+ with both knee osteoarthritis and insomnia will be followed for 6 m…

This study tests a smartphone app called StandUPTV that alerts adults after 30 minutes of evening screen time, encouraging them to stand or move. Researchers want to see if this can reduce total sitting time and improve physical activity, sleep quality, and blood sugar levels. Th…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This study tests whether a non-invasive magnetic brain stimulation treatment (rTMS) can improve sleep in people with chronic insomnia. About 70 adults aged 18 to 85 will receive six 25-minute sessions over two weeks. The goal is to see if insomnia severity and sleep patterns impr…

This trial tests a pair of smart earbuds that use artificial intelligence to adjust soothing music in real time based on your heart rate and movement, aiming to help people with chronic insomnia fall asleep faster and sleep deeper. Adults with chronic insomnia will spend three ni…

This trial tests whether a single live online group session, called STEP-Together, can help cancer survivors who have trouble sleeping. The session provides practical tips on sleep habits, environment, and timing. Researchers will measure changes in insomnia severity and mood eig…

This trial is testing whether a daily liquid supplement called Super Liver Drops can improve gut health, ease digestive discomfort, and boost energy levels. Over 12 weeks, 35 adults aged 30-65 with concerns about low energy and digestive issues will take the supplement each morni…

This pilot study tests whether adding a digital insomnia treatment (CBT-I) to standard suicide-focused therapy (DBT) helps reduce suicidal thoughts and self-harm in teens aged 12-18 who are at high risk for suicide. Forty-four participants will be randomly assigned to receive eit…

This trial tests whether a small device that gently stimulates a nerve in the ear can help pregnant women with insomnia sleep better. Two hundred women in their second or third trimester will receive either active stimulation or a sham version for two weeks, with some starting im…

This trial tests whether a three-week physiotherapy program, starting one week after breast reduction surgery, can reduce pain, improve posture, and boost quality of life. Forty women aged 18 to 50 who have had their first breast reduction will be split into two groups: one recei…

This study tests whether a sleep health coaching program, based on cognitive behavioral therapy for insomnia, can improve sleep in firefighters who have trouble sleeping. About 400 firefighters from 20 fire agencies in Arizona will take part. Half will receive the coaching progra…

This study tests whether adding personalized feedback to an online sleep program helps university students with insomnia. About 70 students will be split into three groups: standard online therapy, enhanced therapy with feedback, or a waitlist. The goal is to see if the extra fee…

This study looks at whether a non-invasive device that stimulates the vagus nerve can improve anxiety, sleep, pain, and itching in teenagers aged 12-18 who have had burn injuries. About 60 participants will either get this stimulation plus standard physical therapy, or just stand…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety, improve sleep, and lessen pain and itching in adults recovering from burn injuries. About 60 participants will either get standard physical therapy plus this nerve st…

This study tests whether a dietary supplement called Dong'e Brand Ejiao Yuanjiang can help improve sleep quality. Researchers will enroll 66 adults aged 25 to 55 and track their sleep over 60 days using questionnaires and wearable devices. The goal is to see if the supplement lea…

This Phase 3 study tests whether nightly doses of CBD (75mg or 150mg) can reduce insomnia severity in adults over 8 weeks. Participants take capsules or a placebo, and researchers measure changes in sleep quality using a standard questionnaire and sleep efficiency. The goal is to…

This study investigates whether menopausal hormone therapy (MHT) can improve sleep quality in women going through menopause. Researchers will compare sleep in women who receive MHT to those who do not, using questionnaires and sleep diaries. The goal is to see if MHT can help wit…

This study tests a modified version of Cognitive Behavioral Therapy for Insomnia (CBTi) to see if it can improve sleep and thinking in adults with insomnia. About 37 participants will receive the therapy and be monitored for changes in sleep quality and cognitive function. The go…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who have lost weight and have little desire to eat. About 98 patients will receive either mirtazapine or a placebo for 29 days. Researchers will track ch…

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This study aims to find the best way to deliver cognitive behavioral therapy for insomnia (CBT-I) to cancer survivors who have chronic sleep problems. Researchers are comparing individual vs. group sessions and whether adding booster sessions helps. The goal is to create an effec…

This study tests whether listening to specific sound frequencies for just 9 minutes a week can improve mental health. 110 adults with mild anxiety, stress, or depression will either sit in a special sound chamber or use headphones. The goal is to see if this simple, drug-free app…

This study tests a mobile app called RN-SLEEP that teaches night-shift nurses cognitive-behavioral strategies to improve sleep and reduce fatigue. 76 nurses will use either the RN-SLEEP app or a control app for several weeks. Researchers will measure sleep duration, quality, and …

This early-phase study looks at whether Emotional Freedom Techniques (EFT) — a practice that combines tapping on acupressure points with counseling — can reduce anxiety, depression, pain, and insomnia in people with cholangiocarcinoma, a rare and aggressive bile duct cancer. Four…

This study tests whether virtual reality (VR) meditation can improve sleep and reduce anxiety in people with chronic pain and insomnia. About 30 adults with both conditions for at least 6 months will use VR meditation and track their sleep, pain, and mood. The goal is to see if t…

This study tests whether virtual yoga classes can help cancer survivors who have trouble sleeping. About 42 survivors will either take 8 virtual yoga sessions over 4 weeks or continue their usual care. Researchers will measure changes in insomnia and sleep quality to see if the o…

This study tests a wearable device called PeakSleep that uses mild electrical stimulation on the brain to help people with insomnia fall asleep faster and wake up less during the night. About 78 adults with insomnia will wear the device at home and track their sleep with a FitBit…

This study tests whether a digital version of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in 140 adults with chronic pain and insomnia. Participants will either receive the digital CBT-I program or digital sleep hygiene education. The goal …

This study tests whether a special type of talk therapy for insomnia (CBT-I) that is customized for shift workers can improve sleep, mental health, and quality of life. About 84 healthcare workers who work rotating shifts including nights will either receive this tailored therapy…

This study compares a home-based, tailored sleep therapy (CBT-I) to a web-based version for 80 caregivers who have insomnia while caring for a child with autism. The goal is to see which approach is more acceptable and feasible for improving sleep and reducing caregiver burden. P…

This study looks at whether a combination of back adjustments (thoracic manipulation) and classic massage can help people with long-term mechanical back pain. About 60 adults aged 18 to 65 with at least 3 years of back pain will receive these treatments. Researchers will measure …

This study tests whether using a virtual reality (VR) relaxation program can reduce nausea and vomiting, improve sleep quality, and increase comfort in pregnant women. About 90 women in early pregnancy (6-14 weeks) will either use VR relaxation or receive standard care. The goal …

This study tests whether watching calming 360-degree videos through virtual reality goggles can improve sleep quality and comfort for older adults (60+) staying in the hospital. Sixty participants will be randomly assigned to either watch the videos for 20 minutes each night or r…

This study tests whether a 9-week online cognitive behavioral therapy program can improve sleep in people with multiple sclerosis (MS). About 550 participants in Norway will either receive the digital therapy or digital education about insomnia. The main goal is to see if the the…

This study tests whether a breathing training program can improve sleep in people whose insomnia is linked to anxiety or depression. Researchers will monitor sleep quality and heart activity in 188 adults. The goal is to find a simple, drug-free way to ease sleep problems and und…

This study tests whether an app that provides cognitive behavioral therapy for insomnia, enhanced with an AI chatbot, can help young people (ages 18-25) sleep better. Half of the 168 participants will use the app with the chatbot, and the other half will use the same app without …

This study compares two mind-body programs—Mahayana Buddhist Awareness Training and Qigong—to see which helps people aged 50-75 with insomnia sleep better. Participants will practice one of these methods and researchers will measure sleep quality, brain activity, and heart rate c…

This study looks at whether adding pelvic floor muscle exercises to deep breathing can help reduce pain during periods in women with primary dysmenorrhea. Forty women will be split into two groups: one doing both exercises, the other only deep breathing. Researchers will measure …

This study tests whether a four-week program called Brief Behavioral Treatment for Insomnia (BBTi) can help middle-aged and older adults with chronic insomnia sleep better and feel less stressed. The program includes sleep education, relaxation techniques, and personalized coachi…

This study tests whether teaching people with type 2 diabetes about good sleep habits and a simple relaxation exercise can help them sleep better, feel less anxious, and improve their blood sugar control. Fifty-two adults with poor sleep quality will be followed for six months. T…

This study tests whether a mobile web-based app can reduce stress and improve sleep quality in nursing students. About 116 students will use the app for 12 weeks, and researchers will measure changes in stress levels and sleep quality. The goal is to find a simple, accessible too…

This study tests whether acupressure (applying pressure to specific points on the body) and back massage can reduce pain, fatigue, and improve sleep quality in women recovering from a cesarean section. About 111 new mothers will receive these non-drug treatments after surgery. Th…

This study tests whether doing simple mouth, tongue, and throat exercises using a mobile app can improve snoring and sleep apnea better than following a paper guide. The 34 participants are adults with mild to severe obstructive sleep apnea who could not or would not use a CPAP m…

This study tests a device called Cereset that plays tones to mirror your brainwaves, aiming to reduce stress, anxiety, insomnia, and depression. About 40 nurses from one hospital unit will use the device. The goal is to see if it improves their well-being and job performance.

This study tests whether a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve sleep and daily functioning in veterans who have both psychosis and insomnia. About 152 veterans are taking part. The goal is to see if better sleep leads to bette…

This phase II study tests whether a computerized cognitive training program can improve sleep and brain health in 240 older adults (65+) with insomnia. Participants will do brain exercises at home for about 36 minutes a day, five days a week, for 36 sessions. The study compares t…

This study tests a new digital app called Stellar Sleep, which provides cognitive behavioral therapy for insomnia (CBT-I) online. It aims to help people with insomnia improve their sleep by using a smartphone or computer, and it can automatically upload sleep data from wearable d…

This study looks at whether actively caring for plants (like watering and pruning) can lower stress, improve mood, and boost academic motivation in college students. About 87 students will either care for plants on campus, at home, or not engage with plants at all. Over a 16-week…

This study looks at whether pranayama breathing exercises can help people with fibromyalgia feel less pain, anxiety, and sleep better. About 54 adults with fibromyalgia will practice these breathing techniques. The goal is to see if this gentle, low-cost approach can improve qual…

This study tests whether two different essential oil blends can reduce agitation (sundowning) and improve sleep in 35 people with dementia living in long-term care. Participants receive a stimulating morning blend and a relaxing afternoon blend, then a calming all-day blend, each…

This study tests whether a short, nurse-led group therapy based on sleep restriction can help people with insomnia. 104 adults with insomnia will either receive the sleep restriction program or standard sleep hygiene advice. The goal is to see if this simpler approach reduces ins…

This study tests whether an 8-week mindfulness program (breathing, body scans, mindful movement) can reduce digital game addiction, stress, and improve sleep in 80 adolescents aged 12-16. Participants are randomly assigned to either the mindfulness group or a control group that c…

This study tests whether a simplified behavioral relaxation program can improve sleep in pregnant women with insomnia. Twenty women in their second or third trimester will receive coaching calls and sleep hygiene tips. The goal is to see if this approach helps them fall asleep fa…

This study compares two non-drug therapies—mindfulness-based therapy and cognitive-behavioral therapy—for pregnant women who have both insomnia and depression. About 100 women in their second trimester will participate to see which approach better reduces sleep problems and depre…

This study tests a special sound app designed to help pregnant women in their first or second trimester who have trouble sleeping. Thirty women will use the app for two weeks, and researchers will track their sleep quality using diaries and smartwatches. The goal is to see if the…

This study looks at whether acceptance and commitment therapy (ACT) can improve sleep for adults with sickle cell disease. Participants will have weekly video chats with a coach for 8 weeks and wear a wrist device to track sleep. The goal is to see if this approach is practical a…

This study is testing whether magnesium L-threonate, a form of magnesium that can reach the brain, improves sleep, recovery, and athletic performance in 100 UCLA varsity athletes aged 18-35. Participants take either the supplement or a placebo nightly for 4 weeks while wearing a …

This study tests whether gentle electrical stimulation to the brain can improve sleep quality and help people with insomnia fall asleep faster. Researchers will compare a personalized stimulation approach to a fixed one and a sham (fake) stimulation. 1000 adults aged 18-75 with i…

This study looks at whether adding stabilization exercises to regular neck exercises helps office workers with neck pain feel better, improve their posture, and sleep more soundly. Thirty participants will do either neck exercises alone or neck exercises plus stabilization exerci…

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This study looks at how what people eat relates to heart health, gut bacteria, sleep quality, and thinking skills in Singapore adults aged 21 to 80. Participants will keep a food diary and provide blood and stool samples to measure things like blood pressure, cholesterol, blood s…

This study looks at whether a woman's ability to notice and interpret body signals is linked to the themes of her dreams. Researchers surveyed 307 adult women about their body awareness, dream themes, emotional state, sleep quality, and physical symptoms. The goal is to see if bo…

This study explores whether complementary therapies like forest therapy (guided time in nature), phytotherapy (herbal treatments), and hirudotherapy (medicinal leeches) can improve physical and mental health in people with reduced work capacity or special needs. Participants are …

This study tests whether simple changes to electronic health records can help doctors prescribe fewer Z-drugs (like Ambien) for insomnia. About 444 primary care clinicians will be randomly assigned to receive either a default of only 10 pills for new orders, an alert suggesting a…

This study was designed to see if cognitive behavioral therapy for insomnia (CBT-I) could help teenagers with ADHD who also have trouble sleeping. It planned to enroll adolescents aged 11-18 with both ADHD and insomnia. However, the trial was withdrawn before any participants wer…

This study explores whether a smartwatch app with personalized reminders can help people with insomnia better track their emotions, diet, exercise, and sleep. Sixty participants will wear a smartwatch and use an app for two weeks, with some receiving reminders timed to their dail…

This study tests a program that offers housing and on-site employment to adults who are at risk of homelessness. Researchers want to see if this approach reduces emergency room visits and improves housing stability, employment, and quality of life. About 750 participants will be …

This study looks at whether spending time at the Belgian coast can improve physical and mental health in people over 60. Sixty retired adults will take a walk along the coast and another walk in the city on different days. They will wear sensors to measure heart rate and stress, …

This study planned to work with teens to improve a mobile app called Firefly, which uses cognitive behavioral therapy to help with insomnia. The goal was to make the app more engaging for teenagers. However, the study was withdrawn before any participants were enrolled, so no res…

This study tested whether a mobile app called 'Smart Nurse' could improve the nutrition, exercise, and sleep habits of high school students aged 14-18. For 12 weeks, 146 teens used the app daily to log meals, activity, and sleep, and received personalized health tips. Researchers…

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study uses a 30-40 minute online survey to understand how being on call affects sleep in 1,000 medical trainees (students, residents, fellows). It looks at sleep quality, quantity, and disruption to body rhythms. The goal is to gather knowledge to improve sleep health for he…

This study looks at how jaw surgery changes not just your bite and appearance, but also your emotions, jaw muscles, and joint health. Researchers will follow 100 patients before and after surgery, using scans, muscle tests, and questionnaires to track these changes. The goal is t…

This study looks at how chronic insomnia affects brain function during memory and emotional tasks, and whether cognitive-behavioral therapy (CBT-I) can reverse those changes. About 120 adults (80 with insomnia and 40 healthy sleepers) will undergo brain scans before and after the…

This study aims to develop an algorithm that can detect insomnia and measure its severity using data from Withings smart devices (like the ScanWatch or Sleep Analyzer) and questionnaires. Researchers will enroll 17,000 adults who already own these devices. The goal is to create a…

This study looks at whether continuous heart rate variability (HRV) monitoring can predict how well patients with inflammatory bowel disease (IBD) respond to biologic therapies like infliximab or vedolizumab. Researchers will track HRV in 100 patients starting treatment and compa…

This study looks at whether taking a special morning and evening food supplement for 6 months can improve blood markers linked to aging in healthy adults aged 50 to 70. Sixty participants will be randomly assigned to take either the supplement or a placebo. Researchers will measu…

This study looks at whether eating a high-carb or high-protein dinner 3-4 hours before bed can help medical residents sleep better. 90 participants will be assigned to one of three meal types for two weeks. Sleep quality will be measured using questionnaires and smartwatches, and…

This study interviews 20 people aged 16-25 who have had bladder or urinary problems since childhood and are now moving from pediatric to adult care. Researchers want to learn about their experiences, challenges, and opinions to make this transition smoother for others. No treatme…

This study follows 1,500 people with long-term pain who are joining rehabilitation programs. Researchers want to understand how insomnia symptoms influence pain, function, and work ability. The goal is to use this knowledge to improve future treatments for chronic pain.

This study looks at how sleep problems like apnea, insomnia, and poor sleep quality are linked to heart disease and diabetes in rural southern areas. About 3,680 adults already in a larger health study will wear sleep trackers and answer questionnaires. The goal is to understand …

This study looks at whether teaching people how to care for their mouth and teeth can improve oral health, sleep, and quality of life for those using a non-invasive ventilator at home. Thirty adults will be split into two groups: one gets standard printed leaflets, the other gets…

This study looks at how the body's natural melatonin levels affect pain and sleep quality after root canal treatment. Forty-five adults will each get two root canals—one in the morning and one in the afternoon. Researchers will measure melatonin in saliva before each treatment an…