INSOMNIA

This study tested whether adding the sleep medication lemborexant (Dayvigo) to the standard alcohol craving drug naltrexone helps people with alcohol use disorder and insomnia. Eight adults took either the combination or naltrexone plus a placebo. Researchers measured alcohol cra…

This study tested whether telehealth coaching from a nurse, based on cognitive behavioral therapy for insomnia (pCBT-I), could prevent or reduce insomnia and depression in 167 adults with low income or education. Participants had early signs of insomnia and were coached to improv…

This study tested whether adding telehealth coaching to a digital cognitive behavioral therapy program helps people with insomnia complete the treatment. 700 adults with insomnia were enrolled. The goal was to see if coaching improves adherence and reduces disparities in who bene…

This study tests if group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either CBT for anxiety or CBT for insomnia. The goal is to see which approach better improves symptoms, sleep…

This study tested whether a noninvasive device that gently stimulates a nerve in the ear (taVNS) could help breast cancer patients with insomnia. Twenty adults with stage I-IV breast cancer who had trouble sleeping for at least three months took part. The main goal was to see if …

This study tests whether cognitive behavioural therapy for insomnia (CBT-I) can improve sleep and ADHD symptoms in adolescents aged 12 to 18 who have both ADHD and insomnia. Participants receive either CBT-I plus usual care or usual care alone. The goal is to see if addressing in…

This study tested whether an AI-guided writing program could help teens feel less anxious, depressed, or stressed. Over three days, 486 Chinese adolescents wrote about negative experiences, with some receiving personalized AI feedback. The goal was to see if this simple, digital …

This study tested a text-message chatbot called Cecebot that combines sleep therapy and activity tips to help breast cancer survivors with insomnia. 60 women with stage I-III breast cancer and poor sleep used the chatbot for 6 weeks. The goal was to see if it was easy to stick wi…

This study tested two sleep medications, trazodone and eszopiclone, in 673 veterans with PTSD-related insomnia. The goal was to see if these drugs could reduce insomnia symptoms over 12 weeks. Participants were adults aged 18-75 with military-related PTSD and insomnia. The study …

This completed trial tested whether combining online acceptance and commitment therapy (ACT) with customized sound therapy helps people with tinnitus and insomnia. 164 adults were split into two groups: one received both therapies, the other only sound therapy. The goal was to se…

This study tested whether a 14-day course of the sleep medication eszopiclone could help people with both insomnia and obstructive sleep apnea use their CPAP machine more consistently. Sixty participants were randomly assigned to receive either eszopiclone or a placebo. The resea…

This study followed 90 Canadian adults with insomnia who were prescribed daridorexant. Researchers tracked changes in quality of life, work productivity, and sleep symptoms over three months using questionnaires. The goal was to see how the medication helps people in everyday lif…

This study tested a home-based brain-training program in 12 autistic adults who also had insomnia. Participants played cognitive games for 18 hours over 6 weeks while wearing a sleep tracker and filling out sleep diaries. The goal was to see if the training was usable and could i…

This study tested two types of therapy for insomnia in 134 people also being treated for alcohol use disorder. The goal was to see if improving sleep could help them stay sober and feel better during the day. Participants received either a standard insomnia treatment or a tailore…

This study tested whether a medication called solriamfetol, cognitive behavioral therapy for insomnia (CBT-I), or both together can help people with insomnia sleep better and feel less tired during the day. 115 adults with insomnia took part. The goal was to see if staying awake …

This study tested whether a simple internet-based self-help program could help people with long-term insomnia stop using sleeping pills like benzodiazepines or Z-drugs. The program used sleep restriction and stimulus control techniques. 62 adults who had been taking sleep medicat…

This study tested whether a guided meditation called yoga nidra is practical and helpful for people with PTSD and insomnia. Sixty adults who had experienced a stressful or traumatic event and had trouble sleeping took part. They listened to online recordings daily for 8 weeks, an…

This early-stage study tested a new insomnia drug called HEC83518 in 74 healthy Chinese adults aged 18 to 45. The main goal was to check safety and side effects after a single dose. Researchers also measured how the drug moves through the body. This is a first step to see if the …

This early-stage trial tested a new drug called HEC83518 in 57 healthy Chinese adults to see if it is safe and how the body processes it. Participants took the drug or a placebo daily for 15 days. The study focused on side effects and drug levels in the blood, not on whether it i…

This study tested a cognitive behavioral therapy (CBT) course for insomnia in 73 adults who also have a chronic physical illness like arthritis, heart disease, or cancer. The therapy focused on changing sleep habits and thoughts about sleep. Results showed that the course helped …

This pilot study tested whether wearing bright light therapy glasses can improve sleep and reduce cravings in people being treated for opioid use disorder. Twenty-three adults on stable medication-assisted treatment (methadone or buprenorphine) with insomnia used either active or…

This study tested the DOZE app, a digital self-management program designed to improve sleep in young adults aged 18-25 with chronic pain and insomnia. Forty participants used the app and a sleep diary for 10 weeks. The goal was to see if the app is easy to use and helps with pain…

This study tested whether taking melatonin before bed can reduce pain and improve sleep in people with chronic low back pain and insomnia. About 220 adults aged 18 to 64 with back pain for at least 3 months and sleep problems took either melatonin or a placebo for several weeks. …

This study tested whether an online program for insomnia could help veterans with COPD sleep better and feel better. 13 veterans were randomly assigned to either the online insomnia treatment or online education about sleep. The goal was to see if the treatment improved sleep qua…

This study tested whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can improve sleep in adults with insomnia. 93 participants were randomly assigned to either receive ACT for 7 weeks or join a waitlist. The therapy encourages people to stop struggling…

This study looked at whether a short sleep therapy program (BBTI) can improve sleep and help people stay in treatment for substance use disorders. About 83 adults living in a residential recovery program took part. They wore sleep trackers, completed surveys, and did sleep diarie…

This study tested whether the sleep medication suvorexant (Belsomra) can reduce insomnia severity and improve metabolic health in midlife women who have both insomnia and signs of metabolic syndrome. Thirty-one healthy women aged 40-65 who were perimenopausal or postmenopausal to…

This study tested an online program to help cancer patients with insomnia. It included 348 adults with cancer who had trouble sleeping. The program used cognitive-behavioral techniques and aimed to see who might need extra help from a professional.

This study looked at whether teaching primary care doctors better ways to treat insomnia can help their patients sleep better. About 485 patients with insomnia symptoms completed surveys. Researchers compared patients whose doctors received special training with those getting usu…

This study tested whether a six-week sleep therapy program (CBT-I) could improve thinking and memory in older adults aged 60-85 with insomnia. Two hundred participants were randomly assigned to either CBT-I or a sleep education program. A small group also had brain scans to see i…

This study looked at whether drinking tart cherry juice can improve sleep in older adults with insomnia. Twenty people aged 65 and older drank cherry juice and a placebo for 4 weeks each while wearing a sleep tracker. Researchers checked if the study was easy to follow and measur…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The drug works by blocking wakefulness signals in the brain. Researchers measured sleep quality and checked for side effects on the liver. The goal was to see if le…

This study tested whether a daily mix of plant protein and two herbs (ashwagandha and rhodiola) could improve sleep in 100 adults aged 35-70 with sleep troubles. Participants took either the supplement or a placebo for 30 days and reported their sleep quality daily. The goal was …

This pilot study tested a non-drug device called Bioboosti to see if it could help people with insomnia sleep better. Twenty adults with insomnia used the device, and researchers measured changes in sleep quality and daytime sleepiness. The goal was to find a safe, drug-free opti…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested daridorexant, a sleep medication, in 166 teenagers aged 10 to 17 with chronic insomnia. Participants took one of three doses of the drug or a placebo each evening. Researchers measured changes in total sleep time using overnight sleep tests and monitored safety.…

This completed Phase 2 trial tested whether Neurexan, a homeopathic tablet, can improve sleep and reduce stress in 81 people with short-term insomnia. Participants took Neurexan or a placebo for 14 days. Sleep efficiency was measured using brain activity and other body signals, w…

This study tested an online sleep education program for young adult cancer survivors (ages 20-39) who have trouble sleeping. Participants took a single online session, with some also getting extra coaching. The goal was to see if it could reduce insomnia and improve mood. The stu…

This study tested whether an online program for insomnia (called SHUTi) could help heavy drinkers reduce their alcohol use. 113 adults who drank heavily and had trouble sleeping took part. The goal was to see if improving sleep would also lead to less drinking and fewer binge epi…

This study tested an herbal compound in 108 adults who had trouble sleeping and tinnitus (ringing in the ears) but did not want to take sleeping pills. Participants took either a low dose, high dose, or placebo daily for 3 months. Researchers measured changes in sleep quality and…

This pilot study tested a brief cognitive behavioral therapy (CBT) program designed to help older adults (55+) safely reduce or stop their use of benzodiazepines, which are commonly prescribed for insomnia and anxiety but can be risky with age. Seventeen participants received the…

This study tested whether a single online education session can help cancer survivors with insomnia sleep better. 70 survivors took part, learning either behavioral changes to improve sleep or relaxation techniques. The goal was to see if a simple, accessible program could ease i…

This study looked at whether two types of talk therapy—Behavioral Therapy and Cognitive Therapy—can help Gulf War Veterans who have trouble sleeping. Fifty veterans took part, and their sleep problems were measured using a standard questionnaire. The goal was to see which therapy…

This study tested whether a headband called Muse-S, which senses brain activity, could help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality …

This study tested whether a digital program called Sleepio, which provides cognitive behavioural therapy for insomnia, could be used by people with mild cognitive impairment or mild dementia. Thirty participants were enrolled to see if the program was acceptable and easy to use. …

This pilot study tested a program called Sleep-SMART for veterans aged 60 and older who have both mild cognitive impairment (MCI) and insomnia. The program combines standard insomnia therapy with memory-support strategies to help participants learn and stick with the treatment. R…

This small pilot study tested whether cannabis oil (with different ratios of CBD to THC) could help with insomnia in people who also have major depression. Fourteen adults took either a high-CBD oil, a low-CBD oil, or a placebo for a short time. The main goal was to see if a larg…

This study tested if an app that teaches better sleep habits could help people with long-term pain and insomnia. 105 adults in a 4-week rehab program either got the app or standard care. The goal was to see if the app improved sleep quality more than rehab alone.

This study tested whether a culturally adapted version of cognitive behavioral therapy for insomnia (CBTi) could help Arab adults sleep better. 54 participants were randomly assigned to receive one of two adapted therapy versions or be placed on a waitlist. The goal was to see if…

This study tested an online insomnia treatment program for adult survivors of childhood cancer. Over 1,500 survivors participated, using a web-based program that teaches healthy sleep habits and cognitive behavioral techniques. The goal was to see if improving sleep could also bo…

This 12-week study tested whether combining acupuncture, yoga, and gradual medication reduction can help adults aged 65 and older lower their use of benzodiazepines (medications for anxiety and insomnia). Twenty-three participants received weekly acupuncture, private yoga classes…

This study tested a smartphone app that teaches older adults (60+) simple behavioral tricks to fall asleep faster and stay asleep longer. 270 participants used either the app or received online sleep tips. The goal was to see if the app could reduce insomnia symptoms more effecti…

This study looked at whether doing tai chi for 24 weeks can improve sleep in college students with insomnia. 90 students were split into three groups: tai chi, brisk walking, or no exercise. The researchers measured sleep quality using a standard questionnaire and also checked le…

This pilot study tested whether a 4-week online sleep therapy program (CBT for insomnia) could help breast cancer survivors take their daily hormone-blocking pills more regularly. 35 women with insomnia who sometimes missed their medication took part. The goal was to see if impro…

This study tested a culturally adapted internet-based cognitive behavioral therapy (iCBT) program for Arabic-speaking refugee and migrant youth aged 15–29 with mild to moderate mental health problems like depression, anxiety, and insomnia. 125 participants were randomly assigned …

This study tested a mobile app called SleepFix that helps people with chronic low back pain and insomnia improve their sleep. Over 100 adults used either the app or received sleep education for 3 weeks. The goal was to see if better sleep could reduce how much pain interferes wit…

This study tested an online sleep program for preschool-aged children with autism who have trouble sleeping. 20 children participated to see if the program was easy to use and helped improve sleep. The goal was to make sleep help more accessible for families.

This study tested suvorexant (Belsomra), an FDA-approved sleep medication, in 40 older adults with insomnia. Participants took the drug or a placebo for two weeks while wearing a motion tracker and completing smartphone surveys about their sleep, mood, and thinking. The goal was …

This study tested whether the sleep medication suvorexant (Belsomra) can help older adults sleep better and reduce confusion after heart surgery. One hundred patients aged 60 and older received either suvorexant or a placebo for seven nights in the ICU. Researchers measured sleep…

This study tested whether a new drug called tasipimidine can help people with insomnia fall asleep faster and stay asleep longer. 190 adults with chronic insomnia took either the drug or a placebo for 3 nights in a sleep clinic, with some continuing for 4 more weeks at home. Rese…

This study tested whether a sleep therapy called CBT-I could reduce depression and anxiety by improving how the brain controls emotions. 51 adults with poor sleep and depression symptoms took part. They met with a psychologist weekly for six weeks to learn better sleep habits. Th…

This study tested whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in women with fibromyalgia. 131 women with both conditions received either CBT-I or sleep hygiene education. Researchers measured sleep quality, pain sensitivity, and bra…

This study tests whether shining low-level laser or LED light on specific acupoints on the hand can help people relax and improve sleep and anxiety. Researchers will measure heart rate and energy levels in 60 healthy volunteers before and after light therapy. The goal is to see i…

This study tested a personalized brain stimulation technique for people with insomnia. Twenty adults received 10 days of treatment, and researchers measured sleep quality and mood changes. The goal was to see if this approach could ease insomnia symptoms.

This study looked at 57 university students with insomnia and compared two 8-week programs: mindfulness-based stress reduction (MBSR) and cognitive behavioral therapy for insomnia (CBT-I). Researchers measured how each program affected sleep quality, stress, anxiety, and mood. Th…

This study tested a capsule containing cannabidiol (CBD) and terpenes to see if it improves sleep quality in people with chronic insomnia. 125 adults with insomnia took either the CBD capsule or a placebo for a period, and their sleep was tracked with a wrist device. The goal was…

This study examines whether ticagrelor, a heart medication, changes how the body absorbs and processes YZJ-1139, an experimental insomnia treatment. Healthy volunteers aged 18 to 45 will take YZJ-1139 alone and then with ticagrelor to compare drug levels and safety. The goal is t…

This study examines whether a new insomnia drug, YZJ-1139, can be safely taken with the antidepressant escitalopram. Healthy adults aged 18 to 45 will receive both drugs and be monitored for side effects, drug levels in the blood, and changes in eye movements, balance, and thinki…

This study examines how the sleep aid YZJ-1139 behaves in people with severe kidney impairment compared to those with normal kidney function. Sixteen adults will receive a single 20 mg dose, and researchers will measure drug levels in the blood and urine, as well as any side effe…

This completed study looked at 1,740 newly married couples to see if the bacteria in their mouth, eyes, and gut are linked to sleep problems, vision issues, and mood. Participants provided samples and completed surveys about sleep, anxiety, depression, and dry eye symptoms. The g…

This study looks at how stress and insomnia are connected. Researchers used driving simulations with stressful events to measure emotional reactions and sleep patterns in 15 women with and without insomnia. The goal is to understand how stress affects sleep and vice versa, which …

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This study looked at whether treating insomnia can reduce the risk of heart disease in people with PTSD. Researchers measured blood pressure, blood vessel health, and other heart risk factors in 140 adults aged 40-59. The goal was to see if improving sleep could also improve hear…

This study looked at 149 adults with high blood pressure and insomnia to understand how poor sleep might raise the risk of heart disease. Researchers used a sleep therapy called CBT-I to see if improving sleep could lower nighttime blood pressure. The goal was to learn more about…

This completed study looked at how blood sugar levels affect sleep in 30 adults with cystic fibrosis-related diabetes. Participants wore devices at home to track glucose and sleep for 10 days. The goal was to see if this kind of remote monitoring is practical and to gather early …

This study looks at how cardiac arrest affects thinking, memory, emotions, and sleep over time. About 200 survivors will take detailed brain tests 7 and 24 months after their cardiac arrest. Their results will be compared to heart attack patients who did not have a cardiac arrest…

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at how to help busy doctors at VA clinics adopt better treatments for three common issues: reducing risky medications in older adults, using blood thinners more safely, and offering talk therapy for insomnia instead of sleep pills. Researchers compared two diffe…

This completed study looked at 171 people with HIV to see if insomnia makes pain worse and increases inflammation. Participants wore sleep trackers, kept sleep diaries, and underwent pain tests. The goal was to understand if poor sleep drives pain and inflammation, which could ma…