INSOMNIA

This study tests whether a drug called dexmedetomidine, given through an IV to induce sleep, can help people with severe insomnia that hasn't improved with other treatments. 180 adults aged 18-65 will receive either the drug plus standard oral medication or standard medication al…

This study tests whether a digital program that combines cognitive behavioral therapy for insomnia with circadian rhythm coaching can prevent depressive symptoms from worsening in college students aged 18-24 who have trouble falling asleep and tend to be night owls. Participants …

This study tests whether a digital insomnia treatment (dCBT-I) can prevent depression in perimenopausal women with sleep problems. 230 women will receive either dCBT-I or sleep hygiene education and be followed for 2 years. The goal is to see if improving sleep reduces depressive…

This pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study tests whether an online sleep improvement program can help people with ongoing concussion symptoms. 70 adults with insomnia after a concussion will use a digital platform for 8 weeks. The goal is to see if better sleep reduces symptoms and improves brain and heart func…

This study tests whether the sleep medication lemborexant can improve both sleep and motor symptoms in people with Parkinson's disease. Forty-four participants will take either lemborexant or a placebo nightly for 28 days. Researchers will measure changes in sleep quality and mov…

This study tests whether a simple, low-cost sleep hygiene education program can improve insomnia as effectively as a standard cognitive behavioral therapy app. About 264 adults with insomnia will be randomly assigned to the education program, the app, or a control group. The goal…

This pilot study tests whether simple bedroom changes and sleep tips can improve sleep for older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to adjust the bedroom environment and provide s…

This study tests whether suvorexant, a medication already approved for insomnia, can help Veterans with PTSD and sleep problems better unlearn fear responses. About 40 Veterans will take either suvorexant or a placebo for 7 nights while researchers measure their skin responses to…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can reduce insomnia severity in physically active adults aged 30-59. Fifty participants will either receive 6 weeks of CBT-I or no treatment. The main goal is to see if CBT-I improves sleep quality and red…

This study tests whether smelling lavender essential oil can improve sleep in women aged 60 and older who are in the hospital and have trouble sleeping. Sixty-four participants will either receive lavender aromatherapy or a placebo, and their sleep quality will be measured using …

This study tests a nurse-led program for insomnia that also uses a health education chatbot. 80 adults with sleep problems will either get the program plus chatbot or just track their sleep. The goal is to see if the chatbot-assisted approach improves sleep, anxiety, depression, …

This study tests whether a non-invasive magnetic brain stimulation treatment (rTMS) can improve sleep in people with chronic insomnia. About 70 adults aged 18 to 85 will receive six 25-minute sessions over two weeks. The goal is to see if insomnia severity and sleep patterns impr…

This study tests whether an artificial intelligence (AI)-guided sleep program is practical and well-liked by adults aged 60 and older who have both insomnia and mild memory concerns. Researchers will enroll 60 participants to check how many people join, stick with the program, an…

This study tests a smartphone app called BELL-001 that plays sounds in sync with your breathing to help you relax and fall asleep. Forty adults with insomnia will use the app every night for 12 weeks. Researchers will track sleep quality, mood, and safety to see if this drug-free…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

This study tests whether a short, telephone-delivered insomnia treatment (BBTI) can improve sleep and cognitive function in 214 older adults with HIV, compared to a mindfulness approach (BMT). Participants will complete four weekly phone sessions and attend in-person visits for s…

This study tests a structured sleep hygiene education program for adults with insomnia. Ten Hong Kong Chinese participants will learn behavior-change techniques to improve their sleep. The goal is to see if this low-cost, non-drug approach is feasible and effective for reducing i…

This study tests whether THC (with or without CBD) can improve sleep in people with solid organ cancer who have insomnia. About 69 participants will receive either THC, a THC/CBD mix, or a placebo as a liquid under the tongue. The goal is to see if these cannabis-based compounds …

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study tests whether daridorexant, a sleep medication, can help people who have both major depression and insomnia. Researchers want to see if it improves sleep quality and also eases depressive symptoms. About 134 adults will take either daridorexant or a placebo for three m…

This study looks at whether a type of talk therapy for insomnia (CBT-I) can also improve markers of metabolic syndrome, like blood sugar and insulin resistance. Twenty adults with insomnia and higher body weight will be randomly assigned to CBT-I or basic sleep tips for 5 weeks. …

This study tests whether a low-level laser applied to specific points on the ear can improve sleep in women with breast cancer who have insomnia. Seventy participants will receive either real or sham laser acupuncture twice a week for five weeks. Sleep quality, fatigue, and mood …

This pilot study will test whether a 6-week program of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and blood sugar control in 30 adults aged 40+ with type 2 diabetes and chronic insomnia. Participants are randomly assigned to CBT-I or usual care, and outco…

This study tests a psychological program designed to improve sleep quality in female university students aged 18-25 who have insomnia. The goal is to see if better sleep helps their thinking skills and academic performance. About 35 participants will take part in the program and …

This study tests a wearable smart eye-mask that combines gentle heat and massage with voice-guided sleep therapy to help people who have both insomnia and sleep apnea. The 4-year project will first explore how the condition works, then develop the device, and finally test it in 1…

This study tests whether a smartphone app called SOLOMIYA is helpful and easy to use for people living under the stress of war in Ukraine. About 80 adults with mild to moderate depression or sleep problems will use the app for a few weeks. The app provides relaxation exercises, m…

This small pilot study will test whether an 8-week group mindfulness program can reduce stress, anxiety, depression, and insomnia in parents caring for children with autism or ADHD. Thirty Chinese caregivers will attend weekly sessions and complete surveys before and after the pr…

This phase 2 trial tests whether a traditional Chinese herbal paste called Ning Shen Dan Xiang Gao Fang, made with donkey-hide gelatin, can improve sleep in adults with chronic insomnia. Sixty participants will take the paste or a placebo twice daily for 8 weeks. Researchers will…

This study tests whether teaching older adults (60+) about healthy sleep habits can reduce insomnia. Over 6 weeks, participants attend two face-to-face sessions and get regular phone follow-ups. The goal is to see if this behavioral approach improves sleep quality without medicat…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study will test whether an 18-day spa therapy program can reduce insomnia severity. About 270 adults who are already scheduled for spa treatment will fill out questionnaires about their sleep, fatigue, pain, and mood before, right after, and two months after the program. The…

This study looks at whether racism-related stress affects how well a digital cognitive behavioral therapy program (Sleepio) works for insomnia in Black adults. One hundred participants will use the app for 6-10 weeks while researchers track their sleep and stress levels. The goal…

This study tests whether wearing blue-blocking glasses at night can help teenagers (ages 12-18) with insomnia or delayed sleep phase disorder who are already receiving psychiatric care. Forty participants will wear the glasses or use real darkness for one week. The goal is to see…

This Phase II trial tests a new drug called APSTZD for people with chronic insomnia. About 222 adults aged 18-64 will receive either APSTZD, an active comparator (Stilnox CR), or a placebo. The main goal is to see if APSTZD reduces time awake after falling asleep, measured by ove…

This pilot study tests whether a smartphone app called SleepFix, combined with support from a psychologist, can help young people aged 16-24 with insomnia. The app uses sleep restriction therapy to reset sleep patterns. The trial will check if the approach is practical and accept…

This study tests a sleep therapy called SleepSMART for older veterans who have both insomnia and mild cognitive impairment (MCI). The therapy adapts standard insomnia treatment with extra memory and learning support. Researchers will compare SleepSMART to standard therapy in 150 …

This study tests whether facial acupuncture and scraping can help people with insomnia sleep better. 82 participants aged 16-30 will receive treatments twice a week for four weeks. Researchers will measure sleep quality and other symptoms to see if this traditional Chinese medici…

This study tests whether a small, home-use ear stimulation device can improve sleep and reduce stress in health sciences students who have trouble sleeping. Sixty students will either receive active stimulation or a placebo for three weeks. The goal is to see if this easy, non-in…

This study tests a special type of acupuncture—dense cranial electroacupuncture plus body acupuncture—in 148 teens aged 15-22 with mild to moderate anxiety or depression. Participants receive treatment twice a week for 8 weeks, and researchers measure changes in anxiety, depressi…

This study tests whether a special type of acupressure—timed to the body's natural daily rhythms—can improve sleep in nursing home residents aged 60 and older. Eighty participants will receive either real or fake acupressure twice a day for four weeks. Researchers will measure sl…

This pilot study will test whether a smartphone app that teaches cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants will use the app for five weeks, and researchers will measure changes in insomnia severity, depress…

This study tests whether daridorexant, a recently FDA-approved sleep medication, can improve sleep quality and daytime alertness in smokers who struggle with insomnia during quit attempts. About 44 adult smokers who smoke at least 10 cigarettes daily will take the drug or a place…

This study tests a high-tech version of cognitive behavioral therapy for insomnia (CBT-I) in adults aged 65 and older. It uses smart devices, sensors, and artificial intelligence to personalize sleep coaching at home. Researchers will compare it to simpler digital sleep programs …

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This study tests whether a special 40 Hz flickering light, used for 30 minutes each night for a week, can improve insomnia in people with Parkinson's disease. Thirty participants will be randomly assigned to receive either the 40 Hz light or a control light. The main goal is to s…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for sleep problems in people with Parkinson's disease. For 7 days, 48 participants will receive either active RIC (using a blood pressure cuff to briefly restrict arm blood flow) or a sham version…

This study tests whether a smartphone app can improve sleep for new parents struggling with insomnia. About 250 first-time parents with babies aged 4-12 months will use the Headspace Health Sleep Program for 18 days. The app combines sleep tracking, cognitive behavioral therapy, …

This study tests a smartphone app called BELL-001 that plays personalized sounds in sync with your breathing to help you relax and fall asleep. 114 adults with insomnia will use the app or a sham version nightly for 4 weeks. Researchers will measure changes in sleep quality and d…

This study tests whether a mobile app called SleepQ can reduce insomnia symptoms in adults. The app provides a 12-week digital cognitive behavioral therapy program, including sleep scheduling and relaxation techniques. Eighty participants will be randomly assigned to use the app …

This study tests whether practicing tai chi for 8 weeks can improve sleep quality in adults aged 40 to 69 with mild to moderate chronic insomnia. Sixty participants will be randomly assigned to either a tai chi group or a walking group. The goal is to see if tai chi offers a safe…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve sleep and reduce anxiety in adults over 60 who have chronic insomnia. Sixty participants will receive tACS sessions, and researchers …

This study tests whether a brief behavioral therapy for insomnia (BBTI) can improve sleep in 58 bereaved adults who have trouble sleeping. Participants will either receive BBTI or sleep hygiene education. The study also looks at whether better sleep eases symptoms of complicated …

This study tests whether a type of talking therapy called Cognitive Behavioral Therapy for Insomnia (CBTi) can improve sleep and reduce mental distress in young people aged 12-24 in Hong Kong who have moderate mental health concerns. Participants will attend six weekly group sess…

This study tests whether low-dose laser acupuncture (LLA) can safely improve sleep in 120 adults with major depressive disorder and insomnia. Participants will receive either real or sham laser acupuncture five times a week for six weeks, while continuing their usual depression m…

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This study will test a new wearable device that monitors your body's internal clock (circadian rhythm) by tracking signals like heart rate and movement. Researchers will compare the device's readings to standard saliva tests in 30 adults who are either healthy, have sleep apnea, …

This pilot study will test whether a drug called dexmedetomidine can reduce activity in a brain region (the locus coeruleus) that may be too active during sleep in people with insomnia. Fifteen adults with insomnia will receive either the drug or a placebo before bed in a crossov…