MULTIPLE SCLEROSIS

This early-phase trial tests a personalized cell therapy for people with progressive multiple sclerosis (MS). The treatment uses the patient's own immune cells, trained in the lab to calm the immune system instead of attacking the body. The goal is to slow disability progression …

This study looks at how well the multiple sclerosis drug ublituximab works when injected under the skin at different spots on the body, and whether an autoinjector device works as well as a regular syringe. About 350 adults with relapsing MS will take part. The goal is to find th…

This early-phase study tests a combination of a CD20 antibody and NK042 cell injection in 20 adults with multiple sclerosis. The goal is to see if the treatment is safe and can help control the disease. Participants will be monitored for side effects and changes in disability ove…

This early-stage study tests a new treatment called QT-019C, which uses specially engineered immune cells (CAR T-cells) to target and attack faulty immune cells in people with severe autoimmune diseases like multiple sclerosis, neuromyelitis optica, and myasthenia gravis. Up to 1…

This study will test hyperbaric oxygen therapy (HBOT) in 100 people with various conditions, including long COVID, Crohn's disease, frostbite, and more. HBOT involves breathing pure oxygen in a pressurized chamber to help the body heal. The goal is to see if HBOT improves quality…

This study looks at whether a 12-week exercise program can help people with relapsing-remitting multiple sclerosis (MS) by reducing nerve damage and preserving brain volume. Researchers will measure a blood marker called neurofilament light chain and use MRI scans to see changes.…

This early-stage study tests a new treatment called CABA-201 for people with multiple sclerosis (MS). It uses a patient's own immune cells, modified to target and destroy certain immune cells that may be attacking the nervous system. The main goal is to check safety and find the …

This study tests a new portable, low-cost MRI scanner designed to diagnose multiple sclerosis (MS) in places where standard MRI machines are too expensive or unavailable. About 50 people with suspected MS will get scanned with both the portable device and a regular MRI to see if …

This study tests a smartphone app (iROLL-O+) designed to help people who use wheelchairs or scooters prevent and manage falls. Researchers will compare the app to standard fall prevention information in 120 adults with spinal cord injury or multiple sclerosis. The goal is to see …

This study tests whether a remote breathing muscle training program can improve breathing strength, quality of life, and physical function in 60 adults with multiple sclerosis. Participants will do exercises for both inhaling and exhaling, with the training load adjusted based on…

This study tests an advanced telerehabilitation system that uses artificial intelligence to give instant feedback during home exercises. The goal is to improve mobility in 94 people with multiple sclerosis who have trouble walking or cannot travel to a clinic. Participants will e…

This study will test if a 12-week exercise program can help people with multiple sclerosis (MS) by improving brain structure and function. Researchers will measure changes in a brain protein called GFAP, brain volume, and physical abilities like walking and thinking. The study in…

This study tests a six-week, nurse-led virtual group program for adult women with multiple sclerosis (MS). The program uses guided reflection and group discussions to help participants explore meaning and purpose in their lives. Researchers will measure changes in how much partic…

This study tests a 12-week lifestyle program for 30 adults with relapsing-remitting multiple sclerosis (MS). The program focuses on nutrition, exercise, sleep, and stress management. Researchers want to see if it can reduce fatigue and improve quality of life, and how it affects …

This early-stage study tests whether a non-invasive brain stimulation technique called rTMS is safe and tolerable for treating depression and fatigue in adults with multiple sclerosis (MS). About 20 participants with MS and moderate-to-severe depression will receive daily rTMS se…

This study tests a digital program that gives people with multiple sclerosis personalized strategies to avoid falls. About 80 participants who have MS and have fallen recently will be split into two groups: one gets the program plus general fall prevention info, the other gets on…

This study tests whether a home-based video game program can help improve arm and hand function in people with multiple sclerosis (MS). Forty adults with MS will be randomly assigned to either play therapeutic exergames or do standard home exercises, both under remote supervision…

This study tests whether a special light and sound stimulation delivered through a virtual reality headset can reduce fatigue in people with multiple sclerosis. Thirty adults with moderate to severe fatigue will receive either the active stimulation or a sham (inactive) version f…

This study tests if a gentle brain stimulation technique (tDCS) can improve movement, balance, fatigue, sleep, and thinking in people with multiple sclerosis. About 40 adults with MS will receive either real or fake stimulation over two weeks. Researchers will check if the treatm…

This study will test a new type of training that uses augmented reality (AR) to help people with multiple sclerosis (MS) improve their walking and thinking at the same time. The training combines physical exercises with mental tasks, like walking while solving a puzzle. Researche…

This study tests whether an intensive program combining physical therapy, counseling, and nutrition advice can help people with multiple sclerosis move better, think clearer, and feel better overall. About 26 adults with MS who can attend regular sessions will take part. The goal…

This study tests whether cetirizine (Zyrtec) causes less sleepiness than diphenhydramine (Benadryl) when given before MS infusions. About 60 adults with multiple sclerosis will take one of the two medicines before their anti-CD20 therapy. The goal is to find which pre-medication …

This study tests a wearable brain-computer interface (BCI) that uses mental imagery to help people with multiple sclerosis improve arm and hand movement. Forty participants will either receive BCI-based neurofeedback plus standard therapy or standard therapy alone over 12 weeks. …

This study will test whether short bursts of high-intensity exercise (HIIT) are better than moderate, steady exercise (MICT) for improving walking, balance, and thinking in 40 adults with multiple sclerosis. Participants will be randomly assigned to one of the two exercise progra…

This study looks at whether a 12-week aerobic exercise program is practical and helpful for people with advanced multiple sclerosis who use wheelchairs. Twelve participants will exercise twice a week under supervision, and researchers will check if it improves fitness, daily func…

This study tests whether a non-invasive device called SCONE™, which sends mild electrical pulses to the spinal cord, can help people with multiple sclerosis move their arms and hands better. Sixty adults with MS will receive either real or sham stimulation while doing hand and ar…

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This study tests whether using a virtual reality (VR) headset at home can improve hand dexterity in people with multiple sclerosis (MS). Sixty adults with MS who have trouble with hand movements will be randomly assigned to either VR training or standard care. The main goal is to…

This study tests whether sensory integration therapy—exercises that help the brain process body signals—can improve walking stability and quality of life in people with multiple sclerosis (MS). About 44 adults with relapsing-remitting MS will be randomly assigned to receive the t…

This study will test a new type of exercise called eccentric cycling for people with multiple sclerosis (MS). The goal is to see if this cycling method can improve muscle strength, walking ability, fatigue, and quality of life better than standard training. The study plans to enr…

This study tracks 30 veterans with multiple sclerosis who have been on ocrelizumab for at least a year. Researchers will measure changes in fatigue, memory, attention, and quality of life over 12 months using tests and questionnaires. The goal is to see if ongoing treatment helps…

This study tests whether a smartphone app called MSCopilot Boost can reduce the impact of fatigue in people with multiple sclerosis better than usual care. About 208 adults with MS and significant fatigue will use the app for 9 months, which includes remote monitoring and a perso…

This early-phase study tests whether a diabetes drug called glibenclamide (glyburide) can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and neuropathic pain will take the oral extended-release drug, and researchers will monitor safety, drug levels…

This study looks at whether acetaminophen (like Tylenol) can reduce walking fatigue in people with multiple sclerosis. Twenty participants will take either the drug or a placebo, then walk on a treadmill until they get tired. A week later, they repeat the test with the opposite p…

This study aims to create and test advanced MRI scanning methods to measure brain changes in people with multiple sclerosis (MS). Researchers will scan healthy volunteers and people with MS using powerful 3-tesla and 7-tesla MRI machines. The goal is to develop standard, reliable…

This pilot study will use brain scans (fMRI) to see how a mild electrical stimulation treatment called TENS affects brain activity in 30 people with Multiple Sclerosis who have fatigue and walking problems. The goal is to understand how TENS works in the brain, not to test it as …

This study looks at how well people with multiple sclerosis can chew and whether that is connected to their thinking skills, disease severity, and nutrition. Researchers will measure chewing, swallowing, cognitive function, and nutritional status in 86 adults with MS. The goal is…

This study looks at what emotional, physical, and environmental factors affect how easily people with multiple sclerosis (MS) and chronic pain can practice mindfulness every day. About 80 participants will use a smartphone app to report their practice and receive guided meditatio…

This observational study looks at how walking fatigue changes the way people with multiple sclerosis walk and increases their risk of falling. Researchers will compare two groups—those who experience walking fatigue and those who don't—using simple walking tests and balance asses…

This study checks if a short questionnaire about bladder symptoms works well in Turkish for adults with spinal cord injury or multiple sclerosis. Researchers will ask 120 people to fill out the form and compare it with other surveys to ensure it is accurate and reliable. The goal…

This study looks at whether three substances in the blood (GFAP, NfL, and VEGF) can show how multiple sclerosis (MS) is getting worse over time. Researchers will measure these markers in 22 adults with progressive MS and compare them to standard tests of disability and thinking. …

This observational study follows 111 children born to women with multiple sclerosis who received rituximab or similar drugs before or during pregnancy. Researchers want to see if the drug affects the baby's immune cells, increases infections, or weakens vaccine responses in the f…

This study looks at whether lead exposure plays a role in multiple sclerosis (MS). Researchers will measure lead levels, oxidative stress markers, and DNA changes in blood samples from 140 people with MS and healthy controls. The goal is to understand how lead might influence MS …

This study aims to see if mixed reality (using a Meta Quest 3 headset) can reliably measure walking, standing, and balance in people with multiple sclerosis. Researchers will compare these digital tests to traditional versions in 75 adults with mild to moderate MS. The goal is to…

This study looks at whether people with multiple sclerosis (MS) have different gum health compared to those without MS. Researchers will measure gum disease signs and check saliva for bacteria and other markers. The goal is to better understand how these two chronic inflammatory …

This study looks at how doing two things at once—like chewing while listening or moving—affects chewing ability in people with multiple sclerosis. Researchers will compare 48 adults with MS to healthy volunteers. The goal is to better understand how MS impacts everyday tasks like…

This study aims to see if artificial intelligence can predict how multiple sclerosis (MS) will progress over time. Researchers will collect basic health information from 53 people with MS and use it to train a computer model. The goal is to better understand and forecast the dise…

This study looks at how changes in the tiny blood vessels at the back of the eye relate to vision problems in people with multiple sclerosis (MS). Researchers will use a special eye scan (OCT-A) and standard vision tests to find connections. The goal is to better understand MS-re…

This study looks at how people with multiple sclerosis (MS) take their medicines at home. Researchers will visit participants once to review all their medications and supplements, ask about their routines and any problems, and check for safety issues. No changes will be made to t…

This study aims to find the best cut-off points for breathing muscle strength and endurance tests to identify disability levels in people with multiple sclerosis (MS). Researchers will measure breathing muscle power and stamina in 40 adults with MS and compare results to their di…

This study looks at how multiple sclerosis (MS) affects a person's sense of smell and the related nerve sensations in the nose. Researchers will test 200 women with MS to measure how they perceive smells and cooling or tingling feelings. The goal is to better understand these sen…

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday clinical practice. Researchers will collect long-te…

This study looks at whether adding computerized cognitive training to walking and resistance exercises can improve gait and reduce falls in older veterans with multiple sclerosis. Thirty participants will be assigned to exercise with or without cognitive training for 10 weeks, th…

This study looks at how a short session of virtual reality (VR) affects balance and motion sickness in people with multiple sclerosis (MS). Researchers will compare 30 adults with MS and healthy controls, measuring sway before and after a 10-minute VR experience. The goal is to u…

This study looks at how trunk (core) stability is linked to balance, walking, arm function, and fatigue in people with mild to moderate multiple sclerosis. Researchers will measure these abilities in 64 participants during a single session. No treatment is given—the goal is simpl…

This study looks at how treatment failure impacts the quality of life, anxiety, depression, and daily activities of 150 adults with relapsing-remitting multiple sclerosis. Researchers will use questionnaires to measure patients' well-being and their experience with healthcare. Th…

This study will follow 100 adults with multiple sclerosis who are starting one of two common oral medications—teriflunomide or dimethyl fumarate. Over 12 months, researchers will measure how well participants can walk and think during sustained activity, and track their fatigue, …

This study looks at how a device that sends small electrical signals to leg muscles affects walking in people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults who have trouble lifting their f…

This pilot study explores whether a musical tool called Ipsilon can help screen and improve cognitive function in people with multiple sclerosis (MS). Thirty-two participants will either use the Ipsilon for 15 minutes daily for a week or start with no intervention, then switch. T…

This study tests a new type of MRI that looks at energy use in the brain to see if it can predict how well multiple sclerosis (MS) patients respond to a common treatment. About 40 adults with relapsing-remitting MS who have not had treatment in the last two years will get this sp…

This study looks at 200 adults who had a specific eye movement problem called internuclear ophthalmoplegia (INO) but did not yet have multiple sclerosis (MS). Researchers want to find out how many of these patients later develop MS and what factors, like certain proteins in spina…

This study looks at whether people with relapsing-remitting multiple sclerosis (RRMS) can have a relapse without any new spots showing up on an MRI scan. Researchers will follow 136 adults who are having a flare-up, giving them an MRI within 6 days to check for active inflammatio…

This observational study looks at how sleep quality impacts cognitive flexibility, physical activity, body awareness, and reaction time in 80 adults with multiple sclerosis. Participants will complete questionnaires and computer tests, and wear an activity tracker for a week. The…

This study looks at why people with multiple sclerosis (MS) struggle to keep working, even with better treatments. Researchers will survey 75 adults with MS who had cognitive tests in the last five years. They want to see how job type, workplace adjustments, and thinking problems…

This study aims to understand if restricting daily eating to an 8-hour window impacts brain health and inflammation in adults with multiple sclerosis (MS). Researchers will measure specific markers in the blood and explore how meal timing affects the body's internal clock. The go…