MULTIPLE SCLEROSIS

This study is testing whether a medication currently used for diabetes can slow down brain and eye nerve damage in people with multiple sclerosis (MS). Researchers will give 120 participants either the study drug or a placebo for about two years and use brain scans to measure cha…

This study aims to see if two common oral medications for multiple sclerosis (MS)—teriflunomide and dimethyl fumarate—differ in how they affect physical and mental fatigue over a year. Researchers will follow 100 adults with MS who are starting one of these medications as part of…

This early-stage study is testing a new personalized cell therapy called KITE-363 for people with severe autoimmune nerve diseases that haven't responded to standard treatments. The therapy involves modifying a patient's own immune cells to target and remove harmful B cells that …

This study aims to see if taking the MS drug ocrelizumab for a long time helps reduce severe fatigue and improve thinking skills like memory and attention in veterans with multiple sclerosis. Researchers will follow 30 veterans already on this medication for a year, checking thei…

This early-stage study is testing a new personalized therapy called CABA-201 for adults with multiple sclerosis (MS) that hasn't responded well to other treatments. Doctors will collect a patient's own immune cells, modify them in a lab to target the cells thought to drive MS, an…

This is an early, exploratory study to test the safety and initial effectiveness of a new therapy called GC012F for people with multiple sclerosis (MS). The therapy involves collecting a patient's own immune cells, modifying them in a lab to potentially target MS, and then infusi…

This early-stage trial is testing a new treatment called MB-CART 2019.1 for people with multiple sclerosis (MS) that continues to get worse despite standard medications. The study will first check if the treatment is safe and find the right dose, then see if it can stop all signs…

This small pilot study explores whether switching from the MS medication ocrelizumab to a similar drug called ublituximab can help patients who experience a 'wearing off' effect, where their MS symptoms return or worsen in the weeks before their next scheduled infusion. The study…

This study is gathering information to see how well hyperbaric oxygen therapy (HBOT) works for over 40 different health conditions. It will enroll about 100 people who have been referred for HBOT for conditions like Long COVID, Crohn's disease, and various ulcers. The main goal i…

This early-phase study is testing a new 'off-the-shelf' cell therapy for people with severe neurological autoimmune diseases that have not responded to other treatments. Up to 15 participants with conditions like multiple sclerosis or myasthenia gravis will receive a single infus…

This early-stage trial is testing a personalized cell therapy designed to slow or stop the progression of disability in people with progressive forms of multiple sclerosis (MS). Doctors will take a patient's own immune cells, modify them in a lab to potentially 'calm' the immune …

This study aims to see if a mixed reality headset (like the Meta Quest 3) can be a reliable and valid tool for measuring mobility in people with multiple sclerosis (MS). Researchers will have 75 participants with MS perform standard mobility tests both in real life and in the vir…

This study is testing a new, portable, and more affordable MRI machine to see if it can accurately diagnose multiple sclerosis (MS). It will compare images from this new portable scanner to those from a standard, large hospital MRI machine in 50 people suspected of having MS. The…

This study is testing whether a new mobile app can help people who use wheelchairs or scooters prevent and manage falls better than standard information. It will compare the personalized iROLL-O+ app against a well-known CDC fall prevention program. The research involves 120 adul…

This study is testing a new digital program designed to help people with multiple sclerosis (MS) prevent falls. It will enroll 80 participants who have MS and have fallen at least once in the last three months. The program provides personalized strategies based on each person's s…

This study aims to see if adding computer-based brain training to a walking and strength exercise program helps prevent falls in older veterans with multiple sclerosis (MS). Thirty participants will be randomly assigned to either exercise with brain training or exercise with simp…

This study is testing whether a short session with virtual reality goggles can help improve balance and reduce feelings of motion sickness in people with multiple sclerosis (MS). Researchers will compare 30 participants—some with MS, some without—measuring their stability before …

This study is testing a wearable headset that lets people with multiple sclerosis (MS) use their thoughts to control exercises in a virtual reality environment. The goal is to see if this brain-computer interface, combined with standard therapy, is better than standard therapy al…

This study is testing whether an AI-powered home exercise system can help improve mobility in people with multiple sclerosis (MS). About 94 participants with MS will use the system, which provides instant feedback on their exercises. The goal is to help people who can't or prefer…

This is a small, early-stage study to check if a common diabetes pill (glibenclamide) is safe and might help reduce nerve pain in people with multiple sclerosis (MS). Ten participants will first take the drug for a few days to ensure it's safe, then continue for three months to s…

This study is testing whether a therapy called sensory integration can help people with multiple sclerosis walk more steadily and improve their daily life. It will involve 44 adults with a specific type of MS, comparing the therapy's effects to a control group. The main goal is t…

This study is testing whether a special light and sound therapy delivered through a virtual reality headset can help reduce the severe fatigue often experienced by people with multiple sclerosis. Thirty participants with moderate to severe MS fatigue will be randomly assigned to …

This study aims to find out which common allergy medicine works better as a pre-treatment before MS infusion therapy. Researchers will compare cetirizine (like Zyrtec) with diphenhydramine (like Benadryl) in 60 MS patients receiving specific infusion treatments. The main goal is …

This small pilot study will test if a home-based video game exercise program can improve arm and hand function for people with multiple sclerosis (MS). Forty participants will be randomly assigned to either use the special exercise games with remote therapist support or to follow…

This study is testing if a special type of cycling, called eccentric cycling, can help people with multiple sclerosis (MS) feel better. Researchers will compare this new exercise to regular cycling to see which one is more effective at improving muscle strength, walking ability, …

This study aims to see if a new type of therapy using augmented reality (AR) games can help people with multiple sclerosis (MS). The AR games are designed to train both the brain and body at the same time, which may improve walking, balance, and thinking skills. Researchers will …

This study is testing a smartphone app called MSCopilot Boost to see if it can help reduce the severe fatigue that affects most people with multiple sclerosis (MS). About 208 participants will use the app for remote monitoring and a personalized exercise program, comparing its ef…

This study is testing whether acetaminophen (the active ingredient in Tylenol) can help people with multiple sclerosis walk longer distances before getting tired. Researchers think the medication might help by slightly lowering body temperature, which could reduce heat sensitivit…

This study is testing whether a home-based virtual reality (VR) training program can improve hand and arm function in people with multiple sclerosis (MS). Researchers will enroll 60 adults with MS who have difficulty with manual dexterity affecting their daily life. Participants …

This study is testing a 4-month intensive outpatient program designed to help people with multiple sclerosis (MS). The program combines specialized physiotherapy, psychotherapy, and nutritional counseling to improve movement, thinking skills, and overall well-being. Researchers w…

This study is testing a new way to do breathing exercises for people with Multiple Sclerosis (MS). Researchers want to see if adjusting the exercise difficulty based on a person's maximum strength is better than the usual method. The goal is to improve breathing muscle strength, …

This study is testing a special suit called EXOPULSE that uses gentle electrical stimulation to relax tight muscles and improve walking in people with multiple sclerosis (MS). It aims to help 77 adults with MS who cannot or do not want to use the main walking medication. Particip…

This study is testing whether a gentle, non-invasive electrical stimulation to the spine can help improve arm and hand function for people with multiple sclerosis (MS). Participants will receive either real or fake stimulation while doing hand and arm exercises to see if the real…

This study aims to understand what helps people with multiple sclerosis (MS) stay employed and feel well. Researchers will survey about 75 adults with MS who have had recent cognitive testing, asking about their jobs, workplace support, and daily life. The goal is to gather infor…

This study aims to understand if certain MS medications taken by mothers before or during pregnancy affect their babies' immune systems. Researchers will follow 111 mother-child pairs to check the babies' blood for immune cell levels, infection rates, and vaccine responses. The g…

This study aims to understand how changes in the tiny blood vessels at the back of the eye relate to vision loss in people with multiple sclerosis (MS). Researchers will use a special, non-invasive eye scan (OCT-A) and standard vision tests on 32 MS patients. The goal is to see i…

This study aims to understand how treatment failure affects people with relapsing-remitting multiple sclerosis (MS). Researchers will survey 150 patients whose initial MS medications stopped working to learn about their quality of life, mental health, and experiences with healthc…

This study aims to develop and test new, more detailed MRI scanning methods for the brain. Researchers will scan healthy volunteers and people with multiple sclerosis (MS) using both standard and very powerful MRI machines. The goal is to create better tools for doctors to measur…

This study aims to understand how specialized Multiple Sclerosis Care Units (MSCUs) help coordinate care between different doctors and services. Researchers will interview patients, caregivers, and healthcare professionals in France and Italy to learn what makes care pathways wor…

This study aims to understand how muscle loss affects breathing in people with multiple sclerosis. Researchers will measure breathing strength and lung function in 40 MS patients who also have muscle loss. The goal is to gather information that could help improve future care, but…

This study aims to understand if there is a connection between multiple sclerosis (MS) and gum disease (periodontitis). Researchers will compare the oral health and saliva of 100 people, half with MS and half without, looking for specific germs and inflammation markers. The goal …

This study aims to understand how core muscle strength and stability are connected to balance, walking ability, arm function, and fatigue in people with mild to moderate multiple sclerosis (MS). Researchers will measure these factors in 64 participants during a single assessment …

This study aims to understand if having trouble chewing is connected to thinking problems, how severe a person's multiple sclerosis is, or their nutritional health. Researchers will measure chewing ability, thinking skills, and overall health in 86 adults with MS. The goal is to …

This study aims to understand if exposure to the toxic metal lead is connected to the development or severity of multiple sclerosis (MS). Researchers will compare 140 people with MS to healthy individuals, measuring lead levels in their blood and looking at related biological mar…

This study aims to test and validate a smartphone app designed to track the health status of people with multiple sclerosis (MS) in their daily lives. It will involve 600 participants internationally to see if the app's digital measurements work reliably across different language…

This study aims to understand if restricting daily eating to a specific time window affects brain health in people with multiple sclerosis (MS). Researchers will measure markers of brain cell health, inflammation, and body clock genes in 22 adults with MS. Participants will be as…

This study aims to see if artificial intelligence (AI) can predict how multiple sclerosis (MS) will progress in a person. Researchers will collect basic health and lifestyle information from 53 people with MS. The AI will analyze this data to try to forecast the future course of …

This study aims to observe and understand how a group of related autoimmune diseases that attack the brain, nerves, and muscles progress over time in real-world patients. It will follow 1,550 adults diagnosed with conditions like multiple sclerosis, myasthenia gravis, and autoimm…

This study aims to understand how chewing is affected in people with multiple sclerosis when they are also doing another task, like listening to sounds or moving. Researchers will compare the chewing performance of 48 people with MS to healthy individuals under these 'dual-task' …

This study aims to understand how a common therapy called TENS (transcutaneous electrical nerve stimulation) affects the brain in people with Multiple Sclerosis (MS). Researchers will use MRI brain scans to measure activity while 15 people with MS and 15 healthy volunteers receiv…

This study aims to find specific breathing strength and endurance levels that can help doctors identify a person's level of disability from multiple sclerosis (MS). Researchers will measure the breathing muscles of 40 adults with MS and compare the results to their disability sco…