MULTIPLE SCLEROSIS

This study tests whether high-intensity breathing exercises can improve respiratory muscle strength, lung function, fatigue, and quality of life in people with multiple sclerosis (MS). Participants are randomly assigned to high-intensity interval breathing training, low-intensity…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This study follows 115 adults with multiple sclerosis who are switching from ocrelizumab to ofatumumab because their antibody levels dropped. Researchers want to see if the switch stops or slows that decline over 24 months. The goal is to better manage immune health while still t…

This Phase 1 trial will test PB018, a biosimilar to the MS drug Ocrevus, in 222 people with multiple sclerosis. The study compares how the body processes PB018 versus Ocrevus and checks for safety. Participants will receive either PB018 or Ocrevus, but neither they nor their doct…

This study looks at whether people with multiple sclerosis can safely switch from their current anti-CD20 therapy to a new under-the-skin version of ocrelizumab. About 100 participants will be followed for up to 48 weeks to see if brain lesions stay stable and if they are satisfi…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study tests whether a structured 12-week program focusing on nutrition, exercise, sleep, and stress management can improve fatigue, physical function, and quality of life in people with relapsing-remitting multiple sclerosis. Thirty participants will first be observed for 12…

This early study tests a new treatment called S103 (BCMA-CAR T cells) in 9 adults with progressive or hard-to-treat multiple sclerosis (MS). The main goal is to see if the treatment is safe and to find the best dose. Researchers will also look for early signs that it might help c…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This phase IIa trial tests a personalized cell therapy for people with progressive multiple sclerosis (MS). The treatment uses the patient's own immune cells, turned into 'tolerogenic dendritic cells' that are designed to calm the immune system and stop it from attacking the nerv…

This early-stage trial tests a new treatment for multiple sclerosis (MS) that combines a drug called ofatumumab with NK042, a therapy made from immune cells donated by healthy people. The study will include 20 adults with different types of MS and will primarily check for safety …

This study tests a drug called ublituximab, given as a shot under the skin, in 350 people with relapsing multiple sclerosis. Researchers want to see how the drug moves through the body when injected in different spots (like the belly or thigh) and whether an autoinjector pen work…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This early-phase trial will test a new treatment called QT-019C in up to 15 adults with relapsed or refractory neurological autoimmune diseases, including multiple sclerosis, neuromyelitis optica, and myasthenia gravis. The treatment uses donor-derived CAR T-cells that target two…

This study tests a digital program that gives people with multiple sclerosis personalized strategies to avoid falls. About 80 participants who have trouble walking and have fallen recently will take part. The program uses each person's fall history to create tailored advice, and …

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This early-stage study tests a new cell therapy called HY001N in 15 adults with relapsed or treatment-resistant autoimmune neurological diseases like neuromyelitis optica. The main goal is to check safety and side effects, while also looking for signs of improvement in disability…

This study tests a new portable, low-field MRI scanner for imaging the brain and limbs in 50 people with suspected multiple sclerosis. The goal is to see if this cheaper, smaller device can produce images good enough to help diagnose MS, especially in places where standard MRI ma…

This study tests whether a 12-week program combining individual physiotherapy, group movement-awareness sessions, and group psychotherapy can improve physical function, reduce fatigue, and enhance quality of life in 45 adults with multiple sclerosis. Each participant serves as th…

This study tests whether a device that delivers high-intensity focused electromagnetic pulses can strengthen core muscles and improve balance in people with multiple sclerosis. Sixty participants will either receive the electromagnetic therapy plus balance exercises, or balance e…

This study tests whether breathing low-oxygen air for short periods right before walking training helps people with multiple sclerosis walk better and farther. Thirty-five participants will receive either the low-oxygen breathing or a sham (placebo) version, followed by treadmill…

This study tests whether an internet-based program called My MS Toolkit can help reduce depression in people with multiple sclerosis. The toolkit teaches skills based on cognitive behavioral therapy to manage common MS symptoms like fatigue, pain, and low mood. Researchers will c…

This early-stage study tests whether short periods of breathing low-oxygen air (called acute intermittent hypoxia) are safe and tolerable for people with multiple sclerosis. Nine participants at different disease stages will be closely monitored for side effects like low oxygen l…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests a 16-week exercise program designed specifically for Hispanic people with multiple sclerosis who have walking problems. About 66 participants will either join the exercise group or a waitlist. The goal is to see if the program improves walking ability and quality…

This study tests whether a daily topical blend of lavender and rosemary essential oils can reduce urinary urgency, frequency, and leakage in adults with multiple sclerosis. Sixty participants will use either the essential oil blend or a placebo oil for six weeks. Researchers will…

This study will test whether high-intensity interval training (HIIT) on a stationary bike can improve walking, balance, and thinking in people with multiple sclerosis (MS). Forty adults with mild to moderate MS will be randomly assigned to either HIIT or moderate-intensity contin…

This study explores whether augmented reality (AR) exercises can help people with multiple sclerosis (MS) improve both their walking and thinking at the same time. Researchers will create AR scenarios that combine physical and mental tasks, then test them in 40 adults with MS. Th…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) is safe and helpful for depression and fatigue in adults with multiple sclerosis (MS). About 20 participants will receive daily rTMS sessions for 5 days, with assessments before, after, and at a 4-…

This study tests whether a six-week, nurse-led virtual group program can help adult women with Multiple Sclerosis (MS) find more meaning and purpose in life, and improve their quality of life. Participants attend weekly online group sessions focused on reflection and values explo…

This study tests if a gentle brain stimulation technique called tDCS can improve movement, balance, fatigue, sleep, and thinking in people with multiple sclerosis. Forty adults with MS will receive either real or sham stimulation over two weeks. Researchers will check if the trea…

This study will test whether a 12-week aerobic exercise program is practical and safe for 12 people with advanced multiple sclerosis who use wheelchairs. Participants will exercise twice a week under supervision. Researchers will measure fitness, daily function, thinking skills, …

This study will test whether a 12-week progressive resistance training program can improve brain health and daily function in people with relapsing-remitting multiple sclerosis. Thirty participants will be randomly assigned to either an exercise group or a control group. Research…

This study tests whether a home-based virtual reality (VR) headset program can improve manual dexterity in people with multiple sclerosis (MS). Sixty participants with MS who have trouble with hand function will be randomly assigned to either the VR dexterity training or a sham m…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests whether acetaminophen (Tylenol) can reduce walking fatigue in people with multiple sclerosis. Twenty participants will take either the drug or a placebo, then walk on a treadmill until they get tired. A week later, they repeat the test with the opposite pill. The…

This study tests a wearable brain-computer interface (BCI) that gives real-time feedback during mental exercises to improve arm movement in people with multiple sclerosis. Forty participants will either receive BCI training plus standard rehab or standard rehab alone for 12 weeks…

This study tests whether cetirizine (Zyrtec) causes less sleepiness than diphenhydramine (Benadryl) when used as a pre-medication before anti-CD20 infusions for multiple sclerosis. Sixty participants will receive either drug 30-60 minutes before their infusion, and researchers wi…

This study tests whether a home-based video game exercise program can improve arm and hand function in people with multiple sclerosis (MS). Forty adults with MS will be randomly assigned to either the exergame program or standard home exercises, both supervised remotely. The goal…

This study tests whether sensory integration therapy can improve walking stability and quality of life in people with multiple sclerosis (MS). About 44 adults with relapsing-remitting MS will be randomly assigned to receive either the therapy or standard care. The therapy uses sp…

This pilot study tests whether a special virtual reality headset that delivers rhythmic light and sound (gamma sensory stimulation) can reduce fatigue in people with multiple sclerosis. Thirty participants with moderate to severe fatigue will receive either the active stimulation…

This study tests a new type of cycling called eccentric cycling for people with multiple sclerosis. Researchers want to see if it improves muscle strength, walking ability, fatigue, and quality of life better than standard cycling. Sixty adults with MS who can walk independently …

This study tests whether an advanced telerehabilitation system, which uses AI to give instant feedback, can improve mobility in people with multiple sclerosis. 94 participants will either use the smart system or follow paper-based exercises at home. The goal is to see if this tec…

This study aims to see if a remote breathing exercise program, which adjusts the difficulty based on each person's maximum effort, can improve breathing strength, endurance, quality of life, and physical function in people with multiple sclerosis. Sixty adults with stable MS will…

This study tests an extended-release tablet called arbaclofen to see if it safely reduces muscle stiffness (spasticity) in people with multiple sclerosis. About 442 adults aged 18 to 65 with MS-related spasticity will receive either the drug or a placebo. The goal is to measure c…

This study tests a comprehensive rehab program for people with multiple sclerosis (MS) that includes physical therapy, counseling, and nutrition advice. The goal is to improve movement, thinking, and overall well-being. About 26 participants with MS will take part in the program …

This early study tests whether an extended-release form of glibenclamide (glyburide), a diabetes drug, can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will receive either the drug or a placebo. The main goal is …

This study tests whether a digital tool called MSCopilot Boost can reduce the impact of fatigue in people with multiple sclerosis better than standard care. The tool includes remote monitoring of walking, dexterity, vision, and cognition, plus a personalized telerehabilitation pr…

This study tests a robotic exoskeleton called CLINICAL EXPLORER in 60 children aged 2 to 17 with neurodevelopmental disorders like cerebral palsy. The device supports walking during 8 therapy sessions. Researchers will check if it is safe, easy to use, and helps improve movement …

This study tests whether a non-invasive device that sends mild electrical currents to the spinal cord (tSCS) can improve upper limb function in people with multiple sclerosis. Sixty participants will receive either active stimulation or a sham (inactive) version during rehabilita…

This study investigates whether balance problems explain why fatigue leads to a greater fear of falling in people with multiple sclerosis (MS). Researchers will assess fatigue, balance, and fear of falling in 40 adults with MS who can walk independently or with a device. The goal…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study looks at how different types of exercise—aerobic and resistance training—affect the immune system and physical abilities in people with relapsing-remitting multiple sclerosis (MS). Researchers will measure changes in blood markers of inflammation and functional tests l…

This study looks at whether the time of day you eat can affect brain health in people with multiple sclerosis. Twenty-two adults with MS will follow a daily eating schedule for a set period. Researchers will measure markers of nerve health and inflammation in the blood. A small g…

This study will follow 2,000 people with multiple sclerosis (MS) for five years to understand why some get worse faster than others. Researchers will use brain scans, eye exams, blood tests, and activity monitors to track changes. The goal is to find factors—like inflammation, bl…

This study looks at how multiple sclerosis (MS) might change a person's sense of smell and the related nerve sensations in the nose. Researchers will test 200 women with MS using simple smell and tickle tests, along with questionnaires about mood and thinking. The goal is to bett…

This study examines patients who have internuclear ophthalmoplegia, a condition that causes trouble moving the eyes sideways, to see how many later develop multiple sclerosis (MS). Researchers will review medical records of 200 patients to identify factors that predict MS convers…

This study will enroll 80 adults with multiple sclerosis and chronic pain to take part in an 8-week online Mindfulness-Based Cognitive Therapy (MBCT) program. Researchers want to understand what emotional, physical, and environmental factors make it easier or harder to practice m…

This pilot study will test whether a musical tool called Ipsilon can screen for and possibly improve cognitive function in people with multiple sclerosis (MS). Thirty-two participants will either use the Ipsilon for 15 minutes daily for a week or start with no intervention, then …

This study looks at whether people with relapsing-remitting multiple sclerosis (RRMS) can have a relapse—new or worsening symptoms—without any visible inflammation on an MRI scan. Researchers will follow 136 adults who are having a suspected relapse, performing early brain and sp…

This study will check if three substances in the blood (GFAP, NfL, and VEGF) are linked to how quickly disability gets worse in people with progressive multiple sclerosis. Researchers will measure these markers and compare them to standard tests of disability and thinking. The go…

This observational study looks at how walking fatigability—getting tired while walking—changes the way people with multiple sclerosis walk and increases their risk of falling. Researchers will compare two groups of 62 participants: those who experience walking fatigue and those w…

This study is translating and testing a short questionnaire called the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) into Turkish. It will involve 120 adults with spinal cord injury or multiple sclerosis who have bladder problems. The goal is to make sure the Turkish vers…

This study will test whether a 12-week progressive resistance training program can improve brain health in people with relapsing-remitting multiple sclerosis. Researchers will measure brain volume and a nerve damage marker in the blood. The trial involves 26 participants and aims…

This study looks at how people with multiple sclerosis (MS) understand and use their medicines at home. Researchers will visit participants once to review all medications and supplements, ask about routines and challenges, and check for safety issues. No changes to treatment will…

This study looks at how a device called the L300, which uses mild electrical pulses to lift the foot during walking, affects people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults to see if …

This study looks at whether adding computer-based cognitive training to walking and resistance exercises can improve walking and reduce falls in older veterans with multiple sclerosis. Thirty veterans will take part in a 10-week program, and their falls will be tracked for a year…

This study will examine whether lead exposure is linked to multiple sclerosis (MS). Researchers will measure blood lead levels, oxidative stress markers, and epigenetic changes in 140 people with MS and healthy controls. The goal is to better understand how environmental factors …

This study will check the gum health of 100 people—half with multiple sclerosis (MS) and half without—by measuring gum pockets, plaque, and inflammation. Researchers will also test saliva for certain bacteria and viruses to see if they are linked to MS. The goal is to better unde…

This study looks at whether chewing function is linked to cognitive skills, disease severity, and nutrition in people with multiple sclerosis. Researchers will assess 86 adults with MS using tests for disability, thinking, swallowing, chewing, and nutrition. The goal is to unders…

This study looks at how treatment failure impacts the quality of life, anxiety, depression, and daily activities of 150 adults with relapsing-remitting multiple sclerosis. Researchers will use questionnaires to measure patients' well-being and their experience with care. The goal…

This study looks at whether simple breathing tests can help detect disability levels in people with multiple sclerosis (MS). Researchers will measure respiratory muscle strength and endurance in 40 adults with MS and compare the results to their disability scores. The goal is to …

This observational study will look at how trunk (core) stability is related to balance, walking ability, arm function, and fatigue in 64 people with mild to moderate multiple sclerosis. Participants will complete a series of standard physical tests in one session, such as timed w…

This study looks at how doing other things at the same time—like listening, watching, or moving—affects chewing in people with multiple sclerosis. Researchers will compare 48 adults with MS to healthy volunteers. The goal is to understand chewing problems better, not to test a tr…

This study will test whether mixed reality (using Meta Quest 3 goggles) can reliably measure walking, standing, and balance in 75 people with multiple sclerosis. Participants will perform standard mobility tests both conventionally and in a mixed reality environment. The goal is …

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday medical practice. Researchers will measure disabili…

This study will collect health data and samples from 100 people with multiple sclerosis over several years. Researchers will use artificial intelligence and data science to find patterns that could help predict how the disease will progress. The goal is to eventually personalize …

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study aims to see if artificial intelligence can predict how multiple sclerosis (MS) will progress over time. Researchers will collect medical information from 53 people with MS and use that data to train a computer model. The goal is to better understand the disease and pot…

This study will compare how often autonomic nervous system problems occur in people with neuromyelitis optica spectrum disorder (NMOSD) versus multiple sclerosis (MS). Researchers will use questionnaires and bedside heart tests to measure symptoms like dizziness, bladder issues, …

This observational study follows 111 women with multiple sclerosis who received rituximab (or similar CD-20 antibodies) before or during pregnancy, and their infants. Researchers will measure the baby's B-cell levels, infection rates, and vaccine responses during the first year o…

This study aims to create better MRI methods for looking at the brains of people with multiple sclerosis (MS). Researchers will test these methods on 272 healthy volunteers and MS patients using both standard (3 Tesla) and ultra-high-field (7 Tesla) MRI machines. The goal is to m…

This study will follow 100 adults with multiple sclerosis who are starting either teriflunomide or dimethyl fumarate as part of their routine care. Over 12 months, researchers will measure how well participants can walk and think during sustained activities, along with their repo…

This study looks at what helps people with multiple sclerosis (MS) keep working and feel good. Researchers will survey about 75 adults with MS who had a thinking-skills test in the last five years. They want to see how job type, workplace changes, and thinking problems affect wor…

This study will follow 30 veterans with multiple sclerosis who have been taking ocrelizumab for at least a year. Researchers will test their memory, attention, and fatigue levels at the start, 6 months, and 12 months using questionnaires and cognitive tests. The goal is to see ho…

This study looks at whether a special eye scan (OCT-A) can detect blood vessel changes in the retina of people with multiple sclerosis (MS) and if those changes match up with vision loss. Researchers will scan the eyes of 32 MS patients and test their visual fields. The goal is t…

This pilot study will use brain scans (fMRI) to understand how transcutaneous electrical nerve stimulation (TENS) affects brain activity in 30 people with multiple sclerosis (MS). TENS is a safe, home-use device that sends mild electrical pulses through the skin. The goal is to l…

This study will test whether a 10-minute virtual reality session can change balance and motion sickness in people with multiple sclerosis (MS). Researchers will compare 30 adults with and without MS, measuring sway before and after the VR stimulation. The goal is to learn how cen…